Bir Hepatit A İnfeksiyonu Olgusunda EDTA’ya Bağlı Pseudotrombositopeni,

Öz

Anahtar Kelimeler

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Bir Hepatit A İnfeksiyonu Olgusunda EDTA’ya Bağlı Pseudotrombositopeni,

Öz

Pseudotrombositopeni kanama riskinde artışa neden olmayan ve trombosittransfüzyonu gerektirmeyen bir iyatrojenik laboratuar fenomenidir. Etilendiaminotetraasetik asid’e (EDTA) bağlı pseudotrombositopeni, otomatik kan sayımındayalancı olarak trombosit sayısındaki azalmayı tanımlamaktadır. Kan örneklerininEDTA ile antikoagule edilmesi sonucunda normal kişilerde oluşabileceği gibi farklıhastalıkların seyrinde de gözlenebilmektedir. Bu yazıda hepatit A infeksiyonu seyrinde gözlenen bir EDTA bağımlı pseudotrombositopeni olgusu sunulmuştur. Olguhalen devam eden pseudotrombositopeni nedeniyle izlenmektedir

Anahtar Kelimeler

• Pseudotrombositopeni, EDTA, hepatit A

Kaynakça

1. Holmes MB, Kabbani S, Watkins MW, Battle RW, Schneider DJ. Images in cardiovascular medicine. Abciximab-associated pseudothrombocytopenia. Circu- lation 2000; 101:938-939.
2. Bizzaro N, Brandalise M. EDTA-dependent pseudo- thrombocytopenia. Association with antiplatelet and antiphospholipid antibodies. Am J Clin Pathol 1995; 103: 103-107. 3. Bizzaro N. EDTA-dependent pseudothrombocytopenia: a clinical and epidemiological study of 112 cases, with 10-year follow- up. Am J Hematol 1995; 50:103-109.
3. Hsieh AT, Chao TY, Chen YC. Pseudothrombocyto- penia associated with infectious mononucleosis. Arch Pathol Lab Med 2003; 127:17-18.
4. Gschwandtner ME, Siostrzonek P, Bodinger C, et al. Documented pseudothrombocytopenia. Ann Hematol 1997; 74:283- 285. onset of
5. Tomonari A, Hirai K, Aoki H, et al. [Pure red cell aplasia and pseudothrombocytopenia associated with hepatitis A]. Rinsho Ketsueki 1991; 32:147-151.
6. Takeuchi T, Yoshioka K, Hori A, Mukoyama K, Ohsawa A, Yokoh S. Cytomegalovirus mononucleosis with mixed cryoglobulinemia presenting transient pseudothrombocytopenia. Intern Med 1993; 32:598- 601.
7. Sawazaki A, Nakamura N, Jyokaji H, Minami S, Nakamura S, Matsuda T. Guillain-Barre syndrome and ethylene diamine tetraacetic acid-dependent pseudo- thrombocytopenia associated with mumps. Intern Med 1996; 35:996-999.
8. Saburi Y, Aragaki M, Matsui S, et al. [An adult patient with EDTA-dependent pseudothrombocytopenia due to rubella virus infection]. Kansenshogaku Zasshi 1993; 67:594-597.

9. Muniz-Diaz E, Domingo P, Lopez M, Pujol-Moix N, Fuster M, Madoz P. [Thrombocytopenia associated with human immunodeficiency virus infection. Immunologic study of 60 patients addicted to parenteral drugs]. Med Clin (Barc) 1993; 101:761-765.
10. Mori M, Kudo H, Yoshitake S, Ito K, Shinguu C, Noguchi T. Transient EDTA-dependent pseudothrom- bocytopenia in a patient with sepsis. Intensive Care Med 2000; 26:218-220.
11. Lipson PJ. What's that platelet count?: A case of pseudothrombocytopenia in an obstetric patient. Anesthesiology 1994; 80:478.
12. Berkman N, Michaeli Y, Or R, Eldor A. EDTA- dependent pseudothrombocytopenia: a clinical study of 18 patients and a review of the literature. Am J Hematol 1991; 36:195-201.
13. Harle JR, Disdier P, Aillaud MF, Swiader L, Weiller PJ. [A virus from the herpes group and pseudothrom- bocytopenia: two cases]. Rev Med Interne 1992; 13:324-325.