Defensinler ve H. pylori Enfeksiyonundaki Rolleri,

Öz

Anahtar Kelimeler

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Defensinler ve H. pylori Enfeksiyonundaki Rolleri,

Öz

Bağışıklık sistemi doğuştan ve edinsel olmak üzere iki gruba ayrılır. Doğuştanbağışıklık sistemi, edinselden farklı olarak daha önce karşılaşmadığı patojenlere karşıhızlı ve devamlı koruma sağlar. Bu sistemin başlıca üyeleri anatomik engeller, salgısalmoleküller ve hücresel bileşenlerdir. Doğuştan bağışıklık sisteminin önemli bir parçasıolan antimikrobiyal peptidlerin memelilerdeki başlıca örnekleri ise defensinlerdir. Bupeptitler birçok enfeksiyonda olduğu gibi H. pylori enfeksiyonunda da görev almaktadırlar. H. pylori enfeksiyonunda defensin düzeyinin arttığı ve eradikasyonla azaldığıbilinmektedir. Ancak bu peptidlerin rolü halen net olarak ortaya konamamıştır. İleride bukonuda yapılacak çalışmalar H. pylori enfeksiyonunun patogenezini aydınlatmada yardımcı olabilir

Anahtar Kelimeler

• Doğuştan bağışıklık sistemi, defensin, H. pylori, çocuk

Kaynakça

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