Gen Transferi-Transfeksiyon Prostat Kanseri STAMP2 Stabil Hücre Hattının Oluşturulması,

Öz

Anahtar Kelimeler

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Gen Transferi-Transfeksiyon Prostat Kanseri STAMP2 Stabil Hücre Hattının Oluşturulması,

Öz

Amaç: DNA- gen transferi, kanserde yapılan gen ekspresyon araştırmalarında

Anahtar Kelimeler

• anahtar rol oynamaktadır. Prostat kanserinin erken döneminde eksprese olan prostat spesifik genleri aradığımız bir projede altı transmembran domaini bulunan bir gen ailesini (six transmembrane protein of prostate- STAMP1 ve 2’yi) tanımladık

Kaynakça

1. Zhou J, Wu Y, Henderson F et al. Adenoviral gene transfer of a mutant surfactant enzyme ameliorates pseudomonas-induced lung injury. Gene ther 2006;13: 974-985.
2. 2. Indraccolo S, Moserle L, Tisato V et al. Gene therapy of ovarian cancer with ıfn-alpha-producing fibroblasts: comparison of constitutive and inducible vectors. Gene ther 2006;13:953-965.
3. 3. Jakobsson J, Nielsen Tt, Staflin K, Georgievska B, Lundberg C. Efficient transduction of neurons using ross river glycoprotein-pseudotyped lentiviral vectors. Gene ther 2006;13:966-973.
4. 4. Misteli, T, Spector DL. RNA polymerase ıı targets premrna splicing factors to transcription sites ın vivo Mol Cell 1999;3, 697-705.
5. 5. Peng Z, Yu Q, Bao L. The application of gene therapy in china. Idrugs 2008;11:346-350. 6. Figueiredo Mİ, Kao C, Wu L. Advances in preclinical investigation of prostate cancer gene therapy. Molecular Therapy 2007; 15: 1053–1064.
6. 7. Freytag SO, Stricker H, Movsas B, Kim JO. Prostate cancer gene therapy clinical trials. Molecular Therapy 2007; 15: 1042–1052.
7. 8. Huggins C, Hodges, CV. Studies on prostatic cancer. I. the effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. J Urol 2002;1941;167: 948-951; discussion 952.
8. 9. Crawford ED, Rosenblum M, Ziada AM, Lange PH. Hormone refractory prostate cancer. Urology, 1999;54: 1-7.

9. 10. Freytag SO, Movsas B, Aref I, et al. Phase i trial of replication-competent adenovirus-mediated suicide gene therapy combined with imrt for prostate cancer. Molecular Therapy, 2007;15:1016-1023.
10. 11. Hubert RS, Vivanco I, Chen E et al. Steap: a prostatespecific cell-surface antigen highly expressed in human prostate tumors. Proc Natl Acad Sci USA 1999;7; 96: 14523-14528.
11. 12. Korkmaz KS, Elbi C, Korkmaz CG et al. Molecular cloning and characterization of stamp1, a highly prostatespecific six transmembrane protein that is overexpressed in prostate cancer. J Biol Chem 2002; 277: 36689-36696.
12. 13. Korkmaz CG, Korkmaz KS, Kurys P et al. molecular cloning and characterization of stamp2, an androgen regulated six-transmembrane protein that is overexp- ressed in a subset of prostate cancers. Oncogene 2005;21; 24:4934-4945.
13. 14. Moldes M, Lasnier F, Gauthereau X et al. Tumor necrosis factor-alpha-induced adipose-related protein (tıarp), a cell-surface protein that is highly induced by tumor necrosis factor-alpha and adipose conversion. J Biol Chem 2001;276: 33938-33946.
14. 15. Steiner MS, Zhang X, Wang Y, Lu Y. Growth inhibition of prostate cancer by an adenovirus expressing a novel tumor suppressor gene, phyde. Cancer Res 2000;15; 60:4419-4425.
15. 16. Passer Bj, Nancy-Portebois V, Amzallag N et al. The p53-inducible tsap6 gene product regulates apoptosis and the cell cycle and interacts with nix and the myt1 kinase. Proc Natl Acad Scı USA 2003;100:2284-2289.
16. 17. Xiao X, Li J, Samulski RJ. Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector. J Virol 1996;70:8098- 8108.
17. 18. Yao Y, Yin H, Shen B et al. Tissue kallikrein promotes neovascularization and improves cardiac function by the akt-glycogen synthase kinase-3b pathway cardiovascular research. 2008; 80: 354-364.