Effects of locally applied clinoptilolite (Froximun®) on seroma formation in a rat mastectomy and axillary lymph node dissection model

Yıl 2019, Cilt: 33 Sayı: 2, 139 - 147, 27.09.2019

Süleyman Özkan Aksoy Cevdet Onur Tunk Ali İbrahim Sevinç Merih Güray Durak

Öz

Objective:
Seroma formation is one of the most
frequent complications following breast cancer surgery. Although many
techniques and drugs have been investigated, no definitive data are available
concerning how to prevent this complication. The present study aims to
investigate impact of local clinoptilolite application on seroma formation in
an experimental mastectomy model created in rats.

Material
and Method: Two groups with seven rats in each were randomised.
Under general anesthesia, all rats underwent right mastectomy and axillary
dissection. Clinoptilolite was locally applied to surgical sites in the study
group, whereas no application was performed in the control group. Ten days
after the surgery, seroma formation was evaluated and tissue samples were
obtained from the surgical sites, for both biochemical and histopathological
examination

Results: There was
statistically significant decrease in seroma formation after clinoptilolite
application (p=0.002). In addition, granulation tissue formation was
significantly higher in the study group (p=0.006). No statistical difference
was found between groups in terms of biochemical parameters.

Conclusion: The reducing
effect of seroma formation by clinoptilolite application may be due to its
crystal cage structure. It collects seroma with its sero-absorbent features and
creates granuloma formation that reduces dead- space, therefore accelarating
wound healing.

Anahtar Kelimeler

seroma, mastectomy, clinoptilolite, wound healing

RATLARDA MASTEKTOMİ VE AKSİLLER DİSSEKSİYON SONRASI KLİNOPTİLOLİT (FROKSİMUN®) KULLANIMININ SEROMA OLUŞUMUNA ETKİSİ

Öz

Amaç: Seroma oluşumu, meme kanseri
cerrahisini takiben en sık görülen komplikasyonlardan biridir. Birçok teknik ve
ilaç araştırılmasına rağmen bu komplikasyonun nasıl önleneceğine dair kesin bir
veri bulunmamaktadır. Bu çalışmada, sıçanlarda oluşturulan deneysel mastektomi
modelinde, lokal klinoptilolit uygulamasının seroma formasyonu üzerindeki
etkisinin araştırılması amaçlanmıştır.Gereç ve Yöntem: Çalışmamızda,
sıçanlar çalışma grubu (n=7) ve kontrol grubu (n=7) olarak iki gruba randomize
edildi. Genel anestezi altında tüm sıçanlara sağ mastektomi ve aksiller
disseksiyon yapıldı. Çalışma grubuna lokal olarak klinoptilolit uygulanırken,
kontrol grubuna herhangi bir uygulama yapılmadı. Ameliyattan on gün sonra,
seroma formasyonu değerlendirildi ve hem biyokimyasal hem de histopatolojik
incelemeler için cerrahi alanlardan doku örnekleri alındı.

Bulgular: Klinoptilolit
uygulanan çalışma grubunda, kontrol grubuna göre seroma oluşumunda
istatistiksel olarak anlamlı azalma saptandı (p = 0,002). Ek olarak, çalışma
grubunda granülasyon dokusu oluşumu anlamlı olarak daha yüksekti (p = 0,006).
Biyokimyasal parametreler açısından gruplar arasında istatistiksel bir fark
bulunmadı.

Sonuç: Seroma oluşumunun klinoptilolit
uygulaması sonrası azalması, kristal kafes yapısına bağlı olabilir. Sero-emici
özellikleriyle seromayı toplar ve ölü boşluğu azaltan, dolayısıyla yara
iyileşmesini hızlandıran granülom yapılarını oluşturur.

Anahtar Kelimeler

seroma, mastektomi, klinoptilolit, yara iyileşmesi

Kaynakça

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