Diagnostic role of platelet indices and leukocyte count in pseudothrombocytopenia

Yıl 2022, Cilt: 36 Sayı: 2, 113 - 122, 30.08.2022

Işıl Erdoğan Özünal

https://doi.org/10.18614/deutip.1174477

Öz

Pseudothrombocytopenia, immune thrombocytopenia, diagnosis, complete blood count indices

Anahtar Kelimeler

Pseudothrombocytopenia, immune thrombocytopenia, diagnosis, complete blood count indices

Diagnostic role of platelet indices and leukocyte count in pseudothrombocytopenia

Öz

Objective: This study aimed to evaluate whether platelet indices and leukocyte count predict the diagnosis of Ethylene Diamine Tetra Acetic Acid induced pseudothrombocytopenia (EDTA-PTCP) and differ this entity from immune thrombocytopenia (ITP).
Methods: One-hundred and sixty-nine individuals (52 patients diagnosed with EDTA-PTCP, 52 patients with newly diagnosed ITP, and 65 healthy individuals) were included. Demographic data and complete blood count (CBC) indices were compared between groups retrospectively.
Results: Age and sex distribution were similar in all groups. Between EDTA-PTCP and ITP groups, no difference was found for absolute leukocyte, neutrophil, lymphocyte, and monocyte counts as well as hemoglobin level, red-cell distribution width (RDW), and platelet distribution width (PDW). The median mean platelet volume (MPV) of the ITP group was found to be higher than the control and EDTA-PTCP groups (p<0.001 and p=0.001, respectively, 95% confidence interval; 2.52-4.45 and 0.56-2.6).

Conclusion: The results support that low platelet count in CBC may be a false result due to EDTA. Thrombocytopenic patients who have no bleeding symptoms and with normal MPV should be evaluated for EDTA-PTCP. This evaluation can be made by a peripheral blood smear or CBC in a blood tube containing other anticoagulants than EDTA (such as citrate or heparin). Therefore the increase in MPV may indicate a diagnosis of ITP rather than EDTA-PTCP. To make a more definite recommendation on this issue, studies involving more patients are needed.

Anahtar Kelimeler

Pseudothrombocytopenia, immune thrombocytopenia, diagnosis, complete blood count indices

Kaynakça

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