FERROPTOSIS; MECHANISMS AND ITS ROLE IN CANCER METABOLISM

Yıl 2024, Cilt: 38 Sayı: 3, 293 - 302, 27.12.2024

Nuseybe Akbal , Duygu Kırkık , Sevgi Kalkanlı Taş

https://doi.org/10.18614/deutip.1521932

Öz

Ferroptosis is a recently described non-apoptotic mechanism of cell death characterized by iron-dependent membrane lipid peroxidation. Morphologically, it is characterized by the presence of abnormally small mitochondria with increased mitochondrial membrane densities, reduction or disappearance of mitochondrial cristae and rupture of the outer mitochondrial membrane. Among others, in oncological diseases defects in the regulation of ferroptosis are implicated. Understanding these mechanisms is important for the development of new therapeutic strategies. This review examines the metabolism, activation and inhibition mechanisms of ferroptosis and its importance in cancer metabolism.

Anahtar Kelimeler

ferroptosis, cell death, immunotherapy, membrane oxidation

FERROPTOZ; MEKANİZMALARI VE KANSER METABOLİZMASINDAKİ ROLÜ

Öz

Ferroptoz yakın zamanda tanımlanmış, demire bağlı membran lipid peroksidasyonu ile karakterize, apoptotik olmayan bir hücre ölüm mekanizmasıdır. Morfolojik olarak, artmış mitokondriyal membran yoğunluklarına sahip normalden küçük mitokondrilerin varlığı, mitokondri kristalarının azalması veya kaybolması ve dış mitokondriyal membranın yırtılması ile karakterize edilmektedir. Ferroptozun düzenlenmesindeki hatalar; pek çok hastalığın yanı sıra onkolojik hastalıklarda da rol oynamaktadır. Bu mekanizmaların anlaşılması yeni tedavi stratejilerinin geliştirilmesi için önem taşımaktadır. Bu derlemede, ferroptozun metabolizması, aktivasyon ve inhibisyon mekanizmaları ile kanser metabolizmasındaki önemi incelenmektedir.

Anahtar Kelimeler

ferroptozis, hücre ölümü, immünoterapi, membran oksidasyonu

Kaynakça

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