Biological Activities of Extracts of Gmelina asiatica L.

Yıl 2022, Cilt: 5 Sayı: 1, 1 - 13, 21.10.2022

Vinujan Shanmugalingam , Saravanan Vivekanandarajah Sathasivampillai , Pholtan Rajeev Sebastian

Öz

Gmelina asiatica L. is a shrub that belongs to the Lamiaceae family. In various traditional medicines, this plant species is employed to cure several disorders like rheumatism, gonorrhea, catarrh of the bladder, edema, and malaria. Furthermore, phytochemicals including cleomeolide; cleomiscosin D; kaempferide-3-glucuronide; nitidine; ovalifolin; and stigmasta-5, 24(28)-diene-3-O-rhamnoside were detected from different parts of G. asiatica. This paper aims to evaluate, summarize, and document the published biological activities related to investigations of G. asiatica. SpringerLink, Semantic Scholar, Scopus, ScienceDirect, Taylor & Francis Online, Wiley Online Library, Sage journals, Mary Ann Liebert, Inc. Publishers, PubMed, and Web of Science databases were used to identify the relevant published articles from 1900 to August 2021. Up to now, only in vivo and in vitro scientific evidence are present for various bioactivities. In addition, anti-anxiety, antibacterial, anticancer, antidandruff, antidiabetic, antifungal, anti-inflammatory, antioxidant, antipyretic, hepatoprotective, and nephroprotective activities were detected for various parts of this plant. This article will be advantageous to carry out support further biological activity investigations of this plant in the future.

Anahtar Kelimeler

Antibacterial, Bioactivity, Gmelina asiatica, Lamiaceae, Siddha Medicine, Sri Lanka

Destekleyen Kurum

Not applicable

Proje Numarası

Not applicable

Teşekkür

The authors appreciative their family members for the support to deliver this work.

Gmelina asiatica L. Ekstraktlarının Biyolojik Aktiviteleri

Öz

Gmelina asiatica L., Lamiaceae familyasına ait bir çalıdır. Çeşitli geleneksel ilaçlarda bu bitki türü, romatizma, bel soğukluğu, mesane nezlesi, ödem ve sıtma gibi çeşitli rahatsızlıkları tedavi etmek için kullanılır. Ayrıca, kleomeolid dahil fitokimyasallar; kleomiskosin D; kaempferid-3-glukuronid; nitidin; ovalifolin; ve stigmasta-5, 24(28)-diene-3-O-rhamnoside, G. asiatica'nın farklı bölümlerinden tespit edildi. Bu makale, G. asiatica araştırmalarıyla ilgili yayınlanmış biyolojik aktiviteleri değerlendirmeyi, özetlemeyi ve belgelemeyi amaçlamaktadır. SpringerLink, Semantic Scholar, Scopus, ScienceDirect, Taylor & Francis Online, Wiley Online Library, Sage dergileri, Mary Ann Liebert, Inc. Publishers, PubMed ve Web of Science veri tabanları, 1900'den Ağustos 2021'e kadar ilgili yayınlanmış makaleleri belirlemek için kullanıldı. Şimdiye kadar, çeşitli biyoaktiviteler için sadece in vivo ve in vitro bilimsel kanıtlar mevcuttur. Ayrıca bu bitkinin çeşitli kısımları için anti-anksiyete, antibakteriyel, antikanser, kepek önleyici, diyabetik, mantar önleyici, iltihap önleyici, antioksidan, ateş düşürücü, hepatoprotektif ve nefroprotektif aktiviteler tespit edilmiştir. Bu makale, gelecekte bu bitkinin biyolojik aktivite araştırmalarını desteklemek için avantajlı olacaktır.

Anahtar Kelimeler

Antibakteriyel, biyoaktivite, Gmelina asiatica, Lamiaceae, Siddha Tıbbı, Sri Lanka

Proje Numarası

Not applicable

Kaynakça

• Bakkiyaraj, S., Pandiyaraj, S. (2011). Evaluation of potential antimicrobial activity of some medicinal plants against common foodborne pathogenic microorganisms. International Journal of Pharma and Bio Sciences, 2 (2), 484–491.
• Balijepalli, M. K., Tandra, S., Pichika, M. R. (2010). Antiproliferative activity and induction of apoptosis in estrogen receptor-positive and negative human breast carcinoma cell lines by Gmelina asiatica roots. Pharmacognosy Research, 2 (2), 113–119 .
• Chandrika, M., Gowda, D.V., Vijayakumar, M., Babu, U. V. (2015). Anti-dandruff activity of supercritical fluids extract of Rosmarinus Officinalis and Gmelina asiatica. Indo American Journal of Pharmaceutical Research, 5 (4), 1463-1467.
• Florence, A. R., Jeeva, S. (2016). Chemical composition of essential oil from the leaves of Gmelina asiatica L . Journal of Medicinal Plants Studies, 4, 8–10.
• Girija, S., Ravindhran, R. (2011). Identification of antioxidant potential of Gmelina asiatica. Biosciences Biotechnology Research Asia, 8, 845–848. https://doi.org/10.13005/bbra/948
• Ikram, M., Khattak, S. G., Gilani, N. (1987). Antipyretic studies on some indigenous Pakistani medicinal plants: II. Journal of Ethnopharmacology, 19, 185–192.
• Jeevan Ram, A., Bhakshu, L. M., Venkata Raju, R. R. (2004). In vitro antimicrobial activity of certain medicinal plants from Eastern Ghats, India, used for skin diseases. Journal of Ethnopharmacology, 90, 353–357. https://doi.org/10.1016/j.jep.2003.10.013
• Kamboj, S. (2015). Pharmacogenetic and anti-anxiety studies on leaves of Gmelina asiatica (Linn.). Medicinal and Aromatic Plants, 4 (4), 103.
• Kasiviswanath, R., Ramesh, A., Kumar, K. E. (2005). Hypoglycemic and antihyperglycemic effect of Gmelina asiatica Linn. in normal and in alloxan-induced diabetic rats. Biological and Pharmaceutical Bulletin, 28, 729–732. https://doi.org/10.1248/bpb.28.729
• Kew Science. Plants of the world online, Gmelina asiatica. (2021). http://www.plantsoftheworldonline.org/taxon/urn:lsid:ipni.org:names:664873-1. Accessed on 08.08.2021.
• Khare, C. (2007). Gmelina asiatica Linn.. In: Khare C. (eds) Indian Medicinal Plants. Springer, New York, NY. https://doi.org/10.1007/978-0-387-70638-2_695
• Kiruba, Arun, K. P., Brindha, P. (2014). In vitro studies on nephroprotective efficacy of Cynodon dactylon and Gmelina asiatica. Asian Journal of Pharmaceutical and Clinical Research, 7, 111–120.
• Kumar, S., Ray, A. B., Konno, C., Oshima, Y., Hikono, H., Cleomiscosin, D. A. (1988). coumarino-lignan from seeds of Cleome viscosa. Phytochemistry, 27, 636.
• Madhu, K. B., Rao Mallikarjuna, P., Balakrishna, P., Vedavathi, T., Satyanarayana, T. (2001). Antimicrobial potential of Gmelina asiatica leaves and Bauhinia vahlii pods. 38, 299-302. Indian Drug Manufacturers Association, Bombay, India.
• Mahendra, C., Gowda, D., Babu, U. (2015). Insignificant activity of extracts of Gmelina asiatica and Ipomoea digitata against skin pathogens. Journal of Pharmaceutical Negative Results, 6, 27–32. https://doi.org/10.4103/0976-9234.157383.
• Merlin (1985). Chemical Investigation of Aerial Parts of Gmelina asiatica Linn by GC-MS. Pharmacognosy Research, 1, 332.
• Merlin, N. J., Parthasarathy, V. (2010). Potential antitumor activity of Gmelina asiatica aerial parts against Dalton ascites lymphoma in mice. Asian Journal of Chemistry, 22, 3193–3199.
• Merlin, N. J., Parthasarathy, V. (2011). Antioxidant and hepatoprotective activity of chloroform and ethanol extracts of Gmelina asiatica aerial parts. Journal of Medicinal Plant Research, 5, 533–538.
• Merlin, N, J., Parthasarathy, V., Manavalan, R., Devi, P., Meera, R. (2009). Phyto-Physicochemical evaluation, Anti-Inflammatory and Anti-microbial activities of Aerial parts of Gmelina asiatica. Asian Journal of Research in Chemistry, 2, 76–82.
• Merlin, N. J., Parthasarathy, V., Santhoshkumar, T. R. (2010). Induction of apoptosis in human breast cancer cell line MCF-7 by phytochemicals from Gmelina asiatica. African Journal of Biotechnology, 9, 4451–4456. https://doi.org/10.4314/ajb.v9i28.
• Parekh, J. (2006). Materials and Methods Collection and Identification of Plant Material. Turkish Journal of Biology, 31, 53–58.
• Parekh, J., Jadeja, D., Chanda, S. (2005). Efficacy of Aqueous and Methanol Extracts of Some Medicinal Plants for Potential Antibacterial Activity. Turkish Journal of Biology, 29, 203–210.
• Rajamanoharan, P., Vivekanandarajah, S. (2021). The role of honey in pediatric treatments in Sri Lankan Siddha Medicine. Uludag Bee Journal, 21, 83–90. https://doi.org/10.31467/uluaricilik.851567
• Satyanarayana, T., Katyayani, B. M., Hema, L.E., Routhu, K. V., Durga Prasad, Y. (2007). Phytochemical studies on root of Gmelina asiatica Linn. Pharmacognosy Magazine, 3 (11), 156-158
• Shibu, A., Sundara Pandian, S. M., Dhanam, S. (2012). Antibacterial activity of the leaf, stem, and root powders of Gmelina asiatica L. Biosciences Biotechnology Research Asia, 9, 297–304. https://doi.org/10.13005/bbra/999
• Silvia, N., Satyanaraya, T. (2014). Phytochemical and antioxidant studies on methanolic extract of Gmelina asiatica Linn stem. International Journal of Pharmacognosy and Phytochemistry Research, 6, 276–281.
• Songsak, T., Lockwood, G. B. (2002). Glucosinolates of seven medicinal plants from Thailand. Fitoterapia, 73, 209-216.
• Sudhakar, M., Rao, C. V., Rao, P. M., Raju, D. B. (2006). Evaluation of antimicrobial activity of Cleome viscosa and Gmelina asiatica. Fitoterapia, 77, 47–49. https://doi.org/10.1016/j.fitote.2005.08.003
• Syed, I. T, Gopalakrishnan, S., Hazeena, B. V. (1997). Biochemical modes of action of Gmelina asiatica in inflammation. Indian Journal of Pharmacology, 29 (5), 306-309.
• Vivekanandarajah, S. (2016b). Plants with Anti-Diabetes Mellitus Properties, 591, Appian Subramoniam, CRC Press (Taylor & Francis Group), Boca Raton (FL, USA). Journal of Ethnopharmacology, 191, 19–20. https://doi.org/10.1016/J.JEP.2016.06.031
• Vivekanandarajah, S. (2017b). Plants historically used to treat diabetes in Sri Lankan Siddha Medicine. International Seminar & Exhibition on Phytopharmaceuticals: Emerging Challenges and Opportunities, Ooty, India.
• Vivekanandarajah, S. (2018b). Plants used to treat diabetes in Sri Lankan Siddha Medicine (Ph.D. Thesis). University College London, London, UK.
• Vivekanandarajah, S. (2021a). Antidiabetic plants used by Sri Lankan Tamils. Jaffna Science Association Newsletter, 28 (3), 3.
• Vivekanandarajah, S. (2021b). நீரிழிவைக் கட்டுப்படுத்த இலங்கைத் தமிழர்கள் உபயோகித்த தாவரங்கள்- பகுதி: 1 (Plants used by Sri Lankan Tamils to manage diabetes – Part: 1). Valampurii Newspaper.
• Vivekanandarajah, S. (2021c). நீரிழிவைக் கட்டுப்படுத்த இலங்கைத் தமிழர்கள் உபயோகித்த தாவரங்கள்- பகுதி: 2 (Plants used by Sri Lankan Tamils to manage diabetes – Part: 2). Valampurii Newspaper.
• Vivekanandarajah, S. (2021d). நீரிழிவைக் கட்டுப்படுத்த இலங்கைத் தமிழர்கள் உபயோகித்த தாவரங்கள்- பகுதி: 3 (Plants used by Sri Lankan Tamils to manage diabetes – Part: 3). Valampurii Newspaper.
• Vivekanandarajah, S. (2021e). Plants historically used by Sri Lankan Tamils to treat diabetes. International Dr. Safiye Ali Multidisciplinary Studies Congress in Health Sciences, İzmir, Turkey.
• Vivekanandarajah, S., Rajamanoharan, P. R. S., Heinrich, M. (2018a). Siddha Medicine in Eastern Sri Lanka Today–Continuity and Change in the Treatment of Diabetes. Frontiers in Pharmacology, 9, 1022. https://doi.org/10.3389/fphar.2018.01022
• Vivekanandarajah, S., Rajamanoharan, P. R. S., Heinrich, M., Munday, M. (2015). Preparations and plants used to treat diabetes in Sri Lankan Siddha Medicine. 3rd International Conference on Ayurveda, Unani, Siddha and Traditional Medicine, Institute of Indigenous Medicine, University of Colombo, Colombo. 67.
• Vivekanandarajah, S., Rajamanoharan, P. R. S., Munday, M., Heinrich, M. (2016a). Plants used to treat diabetes in Sri Lankan Siddha Medicine – An ethnopharmacological review of historical and modern sources. Journal of Ethnopharmacology, 198, 531–599. https://doi.org/10.1016/j.jep.2016.07.053
• Vivekanandarajah, S., Rajamanoharan, P. R. S., Munday, M., Heinrich, M. (2017a). Plants currently used to treat diabetes in Sri Lankan siddha medicine – an ethnobotanical survey in the Eastern province. World Congress Integrative Medicine & Health: part three, Springer Nature, Berlin, Germany. 333. https://doi.org/10.1186/s12906-017-1784-2
• World Checklist of Selected Plant Families. Gmelina asiatica. (2021). https://www.gbif.org/species/5341168. Accessed on 28.07.2021.