Relationship between Neutrophil-to-Lymphocyte Ratio and Prognosis in Patients with Deep Neck Space Infection

Yıl 2016, Cilt: 43 Sayı: 1, 126 - 129, 01.03.2016

Engin Şengül Musa Özbay İsmail Topçu

https://doi.org/10.5798/diclemedj.0921.2016.01.0651

Cited By: 2

Öz

Objective: The aim of this study was to demonstrate if there is any relation between the neutrophil-to-lymphocyte ratio and prognosis in patients with deep neck space infections
Methods: One hundred eight patients who were interned and treated due to deep neck infection in department of otolaryngology between January 2010 and January 2015 were analyzed. Demographics, clinical data, complications and treatment results of patients were evaluated. Pediatric patients between the age of 0 and 14, the patients who had only peritonsillary abscess, infection secondary to trauma were excluded from study. During follow-up and treatment duration the patients with deep neck infections were divided into two groups according to whether they had any complication (group 1) or not (group 2).
Results: Fourteen (13%) patients with deep neck infections had life-threatening complications whereas 94 (87%) did not have any complication during follow-up and treatment duration. The mean neutrophil-to-lymphocyte ratio in patients with complications was significantly higher than the patients without any complications (p<0.05). Also a statistically significant difference was found in advanced age and mean neutrophil value evaluation (p <0.05). However there was no significant difference in mean lymphocyte value (p >0.05).
Conclusion: This study showed that the neutrophil-to-lymphocyte ratio can be used as a cheap, easily obtained and predictive prognostic factor in patients with deep neck infections.
Key words: Deep neck space infection, complication, neutrophil-to-lymphocyte ratio.

Anahtar Kelimeler

Derin boyun enfeksiyonu, komplikasyon, nötrofil/lenfosit oranı

Kaynakça

• Huang TT, Liu TC, Chen PR, et al. Deep neck infection: analysis of 185 cases. Head Neck 2004;26:854-860.
• Boscolo-Rizzo P, Stellin M, Muzzi E, et al. Deep neck infections: a study of 365 cases highlighting recommendations for management and treatment. Eur Arch Otorhinolaryngol 2012;269:1241-1249.
• Yang SW, Lee MH, Lee YS, et al. Analysis of life-threatening complications of deep neck abscess and the impact of empiric antibiotics. ORL J Otorhinolaryngol Relat Spec 2008;70:249-256.
• A. Mantovani, M.A. Cassatella, C. Costantini, S. Jaillon. Neutrophils in the activation and regulation of innate and adaptive immunity. Nat Rev Immunol 2011;11:519-531.
• B. Amulic, C. Cazalet, GL. Hayes, et al. Neutrophil function: from mechanisms to disease. Ann Rev Immunol 2012;30:459-489.
• Nunez J, Nunez E, Bodi V, et al. Usefulness of the neutrophil to lymphocyte ratio in predicting long-term mortality in ST segment elevation myocardial infarction. Am J Cardiol 2008;101:747-752.
• Walsh SR, Cook EJ, Goulder F, et al. Neutrophil lymphocyte ratio as a prognostic factor in colorectal cancer. J Surg Oncol 2005;91:181-184.
• Baglam T, Binnetoglu A, Yumusakhuylu AC, et al. Predictive value of the neutrophil-to-lymphocyte ratio in patients with deep neck space infection secondary to acute bacterial tonsillitis. Int J Pediatr Otorhinolaryngol 2015;79:1421-1424.
• S. Ulu, M. S. Ulu, A. Bucak, et al. Neutrophil-to-lymphocyte ratio as a new, quick,and reliable indicator for predicting diagnosis and prognosis of idiopathic sudden sensorineural hearing loss. Otology & Neurotology 2013;34:1400-1404.
• İlhan M, İlhan G, Gök AF, et al. Evaluation of neutrophillymphocyte ratio, platelet-lymphocyte ratio and red blood
• cell distribution width-platelet ratio as early predictor of acute pancreatitis in pregnancy. J Matern Fetal Neonatal Med 2015;5:1-5.
• Unal D, Eroglu C, Kurtul N, et al. Are neutrophil/lymphocyte
• and platelet/lymphocyte rates in patients with nonsmall cell lung cancer associated with treatment response and prognosis? Asian Pac J Cancer Prev 2013;14:5237-5242.
• Rudiger A, Burckhardt OA, Harpes P, et al. The relative lymphocyte count on hospital admission is a risk factor for long-term mortality in patients with acute heart failure. Am J Emerg Med 2006;24:451-454.
• Yilmaz B, Sengül E, Gül A, et al. Neutrophil–lymphocyte ratio as a prognostic factor in laryngeal carcinoma. Indian J Otolaryngol Head Neck Surg. DOI 10.1007/s12070-014-0769-4.