Stroke in childhood

Yıl 2010, Cilt: 37 Sayı: 3, 314 - 320, 01.09.2010

Gülhis Deda Serap Teber

Öz

Stroke is defined as a sudden occlusion or rupture of ce­rebral arteries or veins resulting in focal cerebral damage and clinical neurologic deficits. Occlusion can be arterial or venous. The incidence of pediatric stroke is 8–10.7/ 100.000 children / year. The risk factors in childhood stroke are multiple and should be detected after the acute state.Since there are not randomized controlled studies for childhood stroke treatment the treatment is still controver­sial and relies on adult literature.

Anahtar Kelimeler

Stroke, acute, childhood, causes, diagnosis, treatment

Çocukluk çağı inmeleri

Öz

İnme, serebral arter ve venlerdeki ani tıkanma veya rüptür sonucunda ortaya çıkan fokal serebral hasardır. Tıkanma arteriyel veya venöz olabilir. Çocukluk çağında görülme riski 8–10.7/100 000 çocuk/yıldır. Hastalarda ani fokal nö­rolojik bulguların varlığı akla iskemiyi getirmelidir.İnmenin çocukluk çağında pek çok risk faktörü vardır, ço­cuklar akut dönem geçtikten sonra bu yönden de incelen­melidir. Çocukluk çağında inme tedavisi randomize çalış­malar olmadığı için erişkin literatürüne dayanmaktadır ve bu nedenle de tartışmalıdır.

Anahtar Kelimeler

İnme, akut, çocukluk çağı, nedenler, tanı, tedavi

Kaynakça

• de Veber G, Cerebrovascular Disease, In: Swaiman KF, Ash- wal S., Ferriero DM eds.Pediatric Neurology, Principles and Practice, 4rd ed. St.Louis Mosby, 2006; 1759-1801.
• Andrew M, Monagle PT, Brooker L. Ed. Tromboembolic complications during infancy and childhood. Hamilton, B.C. Decker Inc., 2000, 201-229.
• Carlin TM, Chanmugam A. Stroke in children. Emerg Med Clin North Am 2002;3:671–85.
• Uysal Z, Doğu F, Kürekçi AE, Deda G, et al. Recurrent arte- ial thrombosis in a child: Primary antiphospholipid anti- body Syndrome. Ped Hem Oncol 2002; 19.59–66.
• Akar N, Akar E, Deda G, et al. Factor V 1691 G-A, prothrom- bin 20210 G-A and methylenetetrahydrofolate reductase 677 C-T variants in Turkish children with cerebral infarct. J Child Neurol 1999; 14.749–51.
• The National Institute of Neurologic Disorders and Stroke rt-PA, Stroke Study Group, 1995.
• deVeber G. Arterial ischemic strokes in infants and children: An overview of current approaches. Semin Thromb Hemost 2003;29:567-73.
• de Veber G, Andrew M. Canadian Pediatric Ischemic Stroke Study Group, Cerebral sinovenous thrombosis in children. N Eng J Med 2001;345: 417.
• Pediatric Stroke Working Group. Stroke in Childhood: Clini- cal Guidelines for Diagnosis, Management and Rehabili- tation, London: Royal College of Physicians of London, 2004.
• Nelson KB, Lynch JK. Stroke in newborn infants. Lancet Neurol 2004;3: 50-8.
• Ozduman K, Pober BR, Barnes P, et al. Fetal stroke. Pediatr Neurol 2004;30:151–62.
• Golomb MR, MacGregor DL, Domi T, et al. Presumed pre- or perinatal arterial ischemic stroke: risk factors and out- comes. Ann Neurol 2001;50.163–8.
• Carvalho KS, Bodensteiner JB, Conolly PJ, Garg PB. Cerebral venous thrombosis in children. J Child Neurol 2001;16.574–80.
• deVeber GA, MacGregor D, Curtis b, Mayank S. Neuro- logic outcome in survivors of childhood arterial ischemic stroke and sinovenous thrombosis. J Child Neurol 2000;15: 16–24.