Correlation of high sensitive C-reactive protein and Hepatitis C Virus RNA in anti-HCV-positive sera
Öz
Objectives: To determine whether the level of high sen­sitive C-reactive protein (hsCRP) secreted from liver dif­fered according to the positivity and negativity of the HCV RNA in sera collected from individuals with HCV antibod­ies. Materials and methods: A total of 84 patients with clini­cally suspected Hepatitis C were included in this study, in which anti-HCV was detected to be positive. Eighty four anti-HCV positive samples were divided into two groups according to the HCV RNA results, as the HCV RNA posi­tive group (Group 1, 50 samples) and the HCV RNA neg­ative group (Group 2, 34 samples). Results: 50 of the 84 samples with anti HCV positivity were detected to be positive for HCV RNA (Group 1), whereas 30 were detected as negative (Group 2). While the hsCRP values were found to be above the normal level in 11 (22%) of the 50 sera samples in the first group, and in 3 (8,8%) of the 34 sera samples in the second group. Conclusion: Numerical comparison of the hsCRP posi­tive samples revealed a statistically significant result in favor of group 1 (p0.05).
Anahtar Kelimeler
Kaynakça
- Garson JA. The polymerase chain reaction and hepatitis C virus diagnosis. FEMS Microbiol Rev 1994; 14(3):224-7.
- Ablij HC, Meinders AE. C-Reactive protein: history and re- vival. Eur J Int Med 2002; 13(4): 412-22.
- Volanakis JE. Human C-Reactive protein: expression, struc- ture and function. Mol Immunol 2001; 38(2): 189-97.
- Moshage H. Cytokines and the hepatic acute phase response. J Pathol 1997; 181(3): 257-66.
- Bird GL, Sheron N, Goka AK, Alexander GJ and Williams RS. Increased plasma tumor necrosis factor in severe alco- holic hepatitis. Ann Intern Med 1990; 56(9):917-20.
- Ishihara K and Hirano T. Moleculer basis of the cell speci- ficity of cytokine action. Biochimica & Biophysica Acta 2002; 1592(2):281-96.
- Paysant J, Blanque R Vasse M, Soria C, Soria J and Gardner CR. Factors influencing the effect of the effect of the solu- ble IL-6 responses in HepG2 hepatocytes. Cytokine 2000; 12(7): 774-9.
- Stevens LA, Adhirkala P, Kaysen G and Levin NW. The im- pact of HCV positive status on mortality and CRP levels in incident hemodialysis patients. J Am Soc Nephrol 2002; 13(3): 223-7.
- Shima M, Nakao K, Kato Y, Nakata K, Ishii N and Naga- taki S. Comparative study of C-Reactive proyein in chronic hepatitis B and chronic hepatitis C. Tohoku J Exper Med 1996; 178(3): 287-97.
- Iancu L, Covic M, Diculencu D, et al. The determination of the prevalence of antibodies to he hepatitis C virus (anti- HCV) and of The serum levels of C-Reactive protein in chronic dialysis patients. Rev Med Chir Soc Med Nat Iasi 1995; 99(1-2):129-33.
- Gedik M, Ozekinci T, Ozbek E, Yılmaz S and Atmaca S. Lack of correlation between CRP and Hepatitis B viral load in serum of patients with chronic HBV. J Infect 2007; 54: 204.
Öz
Amaç: HCV antikoruna sahip kişilerden elde edilen se­rumlarda HCV RNA\'nın pozitif ve negatifliğine göre ka­raciğerden salgılanan hsCRP düzeyinin farklılık belirlen­mesidir. Gereç ve yöntem: Klinik olarak Hepatit-C şüpheli olup anti-HCV\'si pozitif tespıt edilen toplam 84 hasta çalışma­ya dahil edildi. Anti HCV\'si pozitif 84 örnek, HCV RNA sonuçlarına göre; HCV RNA\'sı pozitif grup (Grup 1, 50 örnek) ve HCV RNA\'sı negatif grup (Grup 2, 34 örnek) olmak üzere iki gruba ayrıldı. Bulgular: HCV\'si pozitif 84 örneğinin 50\'sinde HCV RNA pozitif (Grup 1), 34\'ünde HCV RNA negatif (Grup 2) ola­rak tespit edildi. 1.grupta 50 serum örneğinin 11\'de (%22 ), 2.grupta 34 serum örneğinin 3\'de (%8.8) hsCRP değer­leri normal değerin üzerinde tespit edildi. Sonuç: Örneklerin sayısal olarak karşılaştırıldığında Grup 1 lehine istatistiksel olarak anlamlı bulundu (p0.05).
Kaynakça
- Garson JA. The polymerase chain reaction and hepatitis C virus diagnosis. FEMS Microbiol Rev 1994; 14(3):224-7.
- Ablij HC, Meinders AE. C-Reactive protein: history and re- vival. Eur J Int Med 2002; 13(4): 412-22.
- Volanakis JE. Human C-Reactive protein: expression, struc- ture and function. Mol Immunol 2001; 38(2): 189-97.
- Moshage H. Cytokines and the hepatic acute phase response. J Pathol 1997; 181(3): 257-66.
- Bird GL, Sheron N, Goka AK, Alexander GJ and Williams RS. Increased plasma tumor necrosis factor in severe alco- holic hepatitis. Ann Intern Med 1990; 56(9):917-20.
- Ishihara K and Hirano T. Moleculer basis of the cell speci- ficity of cytokine action. Biochimica & Biophysica Acta 2002; 1592(2):281-96.
- Paysant J, Blanque R Vasse M, Soria C, Soria J and Gardner CR. Factors influencing the effect of the effect of the solu- ble IL-6 responses in HepG2 hepatocytes. Cytokine 2000; 12(7): 774-9.
- Stevens LA, Adhirkala P, Kaysen G and Levin NW. The im- pact of HCV positive status on mortality and CRP levels in incident hemodialysis patients. J Am Soc Nephrol 2002; 13(3): 223-7.
- Shima M, Nakao K, Kato Y, Nakata K, Ishii N and Naga- taki S. Comparative study of C-Reactive proyein in chronic hepatitis B and chronic hepatitis C. Tohoku J Exper Med 1996; 178(3): 287-97.
- Iancu L, Covic M, Diculencu D, et al. The determination of the prevalence of antibodies to he hepatitis C virus (anti- HCV) and of The serum levels of C-Reactive protein in chronic dialysis patients. Rev Med Chir Soc Med Nat Iasi 1995; 99(1-2):129-33.
- Gedik M, Ozekinci T, Ozbek E, Yılmaz S and Atmaca S. Lack of correlation between CRP and Hepatitis B viral load in serum of patients with chronic HBV. J Infect 2007; 54: 204.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Araştırma Yazıları |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Haziran 2011 |
| Gönderilme Tarihi | 2 Mart 2015 |
| Yayımlandığı Sayı | Yıl 2011 Cilt: 38 Sayı: 2 |