Measurement of bone mineral density in patients with psoriasis vulgaris

Yıl 2013, Cilt: 40 Sayı: 4, 621 - 626, 01.12.2013

Nurgül Köse

https://doi.org/10.5798/diclemedj.0921.2013.04.0344

Cited By: 1

Öz

Objective: The aim of this study was to determine the changes of bone mineral density in patients with psoriasis vulgaris. Methods: 33 patients, diagnosed with psoriasis vulgaris in Erciyes University, Medical School, Department of Dermatology, and 23 healthy subjects as control group were included in this study. Lumbar and femur bone mineral density of all patients and control group were measured. Biochemical tests related to bone metabolism were performed. Results: We did not find statistically significant difference between patient and control groups' bone mineral density. However, the lumbar spine t score of men, were found to be significantly lower in the patient group than the control group (p

Anahtar Kelimeler

Psoriasis vulgaris, bone mineral density, osteoporosis

Psöriazis vulgarisli hastalarda kemik mineral yoğunluğu ölçümü

Öz

Amaç: Psöriazis vulgaris hastalarında kemik mineral yoğunluğundaki değişikleri saptamak. Yöntemler: Bu çalışmaya, Erciyes Üniversitesi Tıp Fakültesi Dermatoloji Kliniği\'nde tanı almış 33 psöriazis vulgarisli hasta ve kontrol grubu olarak da 23 sağlıklı birey seçildi. Tüm hastalar ve kontrol grubunun lomber ve femur kemik mineral yoğunlukları ölçüldü. Kemik metabolizmasını etkileyen biyokimyasal tetkikler yapıldı. Bulgular: Hasta ve kontrol grubunun kemik mineral yoğunlukları arasında istatistiksel olarak anlamlı fark bulunmadı. Ancak erkeklerde lomber bölgede t skoru hasta grubunda kontrol grubuna göre anlamlı derecede azalmış olarak bulundu (p

Anahtar Kelimeler

Psöriazis vulgaris, kemik mineral yoğunluğu, osteoporoz

Kaynakça

• Aydemir EH. Psöriasis ve benzeri dermatozlar. In: Tüzün Y, Kotoğyan A, Aydemir EH, Baransu O. Dermatoloji. Nobel Top Kitapevi, 1994:315-332.
• Griffiths C, Kirby B. Epidemiology. In: Griffiths C, Kirby B. Psoriasis. Martin Dunitz Ltd, London 1999: 22-24.
• Krueger JG. The immunologic basis for the the treatment of posiriasis with new biologic agents. J Am Acad Dermatol 2002;46:1-23.
• Griffiths C, Kirby B.Psoriatic arthritis. In: Griffiths C, Kirby B. Psoriasis. Martin Dunitz Ltd, London 1999: 22-24.
• Arasıl T. Psöriatik artrit. In: Beyazova M, Kutsal YG. Fi- ziksel Tıp ve Rehabilitasyon. Güneş Kitabevi, Ankara 2000:1598-1603.
• Nymann P, Kollerup G, Jemec GB, Grossmann E. Decreased bone mineral density in patient with pustulosis palmaris et plantariks. Dermatology 1996;192:307-3011.
• Koçak M, Özel S, Ekşioğlu M. Palmoplanter püstülozlu has- talarda kemik mineral yoğunluğunda azalma. T Klin J Der- matol 1999;9:210-215.
• Frediani B, Allegri A, Falsetti P, et al. Bone mineral density in patient with psoriatic arthritis. J Rheumatol 2001;28:138- 143.
• Nolla JM, Fiter J, Rozadilla A, et al. Bone mineral density in patients with peripheral psoriatic arthritis. Rev Rheum Engl Ed 1999;10:457-461.
• Sindel D. Sekonder osteoporoz. In: Kutsal YG. Osteoporoz. Güneş Kitabevi, Ankara 2001:66-81.
• Joffe I, Epstein S. Osteoporosis associated with rheumatoid arthritis: pathogenesis and management. Semin Arthritis Rheum 1991:20:256-272.
• Mundy GR. Bone remodeling and its disorders, 2nd ed. Mertin Dunitz, London 1999:45-82.
• Arend WP. The balance between IL-1 and IL-1Ra in dis- ease. Cytokine Growth Factor Rev 2002;13:323-340.
• Ishihara K, Hirano T. IL-6 in autoimmune disease and chronic inflammatory proliferative disease. Cytokine Growth Factor Rev 2002;13:357-368.
• Bonifati C, Ameglio F. Cytokine in psoriasis. Int J Dermatol 1999;38:241-251.
• Millard TP, Antoniades L, Evans AV, Smith HR, Spec- tor TD, Barket JN. Bone mineral density of patients with chronic plaque psoriases. Clin Exp Dermatol 2001;26:446- 448.
• Israel E, Banerjee TR, Fitzmaurice GM, Kotlov TV, La- Hive K, LeBoff MS. Effects of inhaled glucocorticoids on bone density in premenopausal women. N Engl J Med 2001;345:941-947.
• Sivri A, Çöplü L. Effect of the long-term use of inhaled cor- ticosteroids on bone mineral density in asthmatic women. Respirology 2001;6:131-134.
• Kanis JA. Assessment of fracture risk and its aplication to screening for postmenopausel osteoporosis: synopsis of a WHO report. WHO Study Group. Osteoporosis Int 1994; 4:368-381.
• Pedreira PG, Pinheiro MM, Szejnfeld VL. Bone mineral density and body composition in postmenopausal women with psoriasis and psoriatic arthritis. Arthritis Res Ther 2011;13:10-16.
• Borman P, Babaoğlu S, Gur G, Bingöl S, Bodur H, Bone mineral density and bone turnover in patient with psoritic artritis. Clin Rheumatol 2008;27:443-447.
• Dheda K, cassim B, patel N, Mody GM. A comparison of- bone mineral density in İndians with psoriatic polyartritis and healthy Indian volunteers. Clin Rheumatol 2004;23:89.