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Clinical course and signs in patients with uveitis associated with ankylosing spondylitis

Yıl 2013, Cilt: 40 Sayı: 3, 418 - 421, 01.09.2013
https://doi.org/10.5798/diclemedj.0921.2013.03.0301

Öz

Aim: To evaluate clinical course and signs in patients with uveitis associated ankylosing spondylitis (AS). Methods: In this retrospective study we evaluated the patients who were diagnosed as uveitis related to AS and followed up at the Ophthalmology Department of Necmettin Erbakan University Hospital between May 2009 and June 2012. Demographical features and clinical courses were assessed. Results: Seventeen eyes of 13 patients were included in the study. Nine patients (69.2%) were male and four (30.8%) were female. The mean age at presentation was 38.54±9.61 years (range 28-63). Bilateral involvement was observed in four (30.8%) patients. The mean follow-up time was 17.46±11.86 months (range 3-36). The mean number of attacks was 1.15±0.37 (range 1-2). Posterior segment manifestation accompanied anterior uveitis in three eyes (17.6%). Posterior synechia developed in one (7.7%) and cataract in one patient (7.7%), cystoid macular edema in two patients (15.4%), and epiretinal membrane in one patient (%7.7). The mean final visual acuity was 0.975±0.07 (range 0.2-1.0). Conclusion: The prognosis of anterior uveitis associated with AS is good if the treatment is administered at the appropriate time. However, the posterior segment complications may develop in these patients, treatment and follow-up should be done in co-operation with the department of rheumatology.

Kaynakça

  • Van der Linden S, Vonder Heide D, Braun J. Ankylosing spondylitis. In: Harris ED, editor. Kelley’s text book of rheumatology. 7th ed. 2006. p. 1125-1138.
  • Çalgüneri M. Ankilozan spondilit. İmmünoloji-Romatoloji Dergisi 2004;4:29-37.
  • Khan MA, Van der Linden SM. Ankylosing spondylitis and other spondylo artropathies. Rheum Dis Clin North Am 1990;16:551-579.
  • Rodriguez A. Calonge M, Pedroza-Seres M, et al. Refferal patterns of uveitis in a tertiary eye care center. Arch Oph- thalmol 1996;114:593-599.
  • Rothava A, vanVeenendaal WG, Lissen A, et al. Clini- cal features of acute anterior uveitis. Am J Ophthalmol 1987;103:137-145.
  • Rosembaum JT. Acute uveitis and spondyloarthropathies. Rheum Dis Clin North Am 1992;18:143-152.
  • Sampaio-Barros PD. Epidemiology of spondyloarthritis in Brazil. Am J Med Sci 2011;341:287-288.
  • Reveille JD, Ball EJ, Khan MA. HLA-B27 and genetic predisposing factors in spondyloarthropathies. Curr Opin Rheumatol 2001;13:265-272.
  • Chang JH, McCluskey PJ, Wakefield D. Acute anterior uve- itis and HLA-B27. Surv Ophthalmol 2005;50:364-388.
  • Zink A, Braun J, Listing J, Wollenhaupt J. Disability and handicap in rheumatoid arthritis and ankylosing spondy- litis - results from the German rheumatological database. German Collaborative Arthritis Centers. J Rheumatol 2000;27:613-622.
  • Mattey DL, Dawson SR, Healey EL, Packham JC. Rela- tionship between smoking and patient-reported measures of disease outcome in ankylosing spondylitis. J Rheumatol 2011;38:2608-2615.
  • Chung HY, Machado P, van der Heijde D, et al. Smokers in early axial spondyloarthritis have earlier disease onset, more disease activity, inflammation and damage, and poor- er function and health-related quality of life: results from the DESIR cohort. Ann Rheum Dis 2012;71:809-816.
  • Ündar L, Güler C, Işık O, ve ark. Akut anterior üveitte sakroileit sıklığı. Cumhuriyet Üniversitesi Tıp Fakültesi Dergisi 1988;10:1-2.
  • Bañares A, Hernández-García C, Fernández-Gutiérrez B, Jover JA. Eye involvement in the spondyloarthropathies. Rheum Dis Clin North Am 1998;24:771-784.
  • McCannel CA, Holland GN, Helm CJ, et al. Causes of uve- itis in the general practice of ophthalmology. Am J Ophthal- mol 1996;121:35-46.
  • Rodriguez A, Akova YA, Pedroza-Seres M, Foster CS. Posterior segment ocular manifestations in patients with HLA-B27-associated uveitis. Ophthalmology 1994;101:1267-1274.
  • Tay-Kearney ML, Schwam BL, Lowder C, et al. Clinical features and associated systemic diseases of HLA-B27 uve- itis. Am J Ophthalmol 1996;121:47-56.
  • Rothova A, van Veenedaal WG, Linssen A, et al. Clini- cal features of acute anterior uveitis. Am J Ophthalmol 1987;103:137-45.
  • Trevisani VF, Mattos KT, Esteves RF, et al. Auto antibod- ies specificity in acute anterior uveitis according to the presence of the HLA-B27 allele. Ocul Immunol Inflamm 2001;9:231-242.
  • Suhler EB, Martin TM, Rosenbaum JT. HLA-B-27-associ- ated uveitis: overview and current perspectives. Curr Opin Ophthalmol 2003;14:378-383.
  • Smith JR, Rosenbaum JT. Management of uveitis: a rheu- matologic perspective. Arthritis Rheum 2002;46:309-318.
  • Altan L, Bingol U, Karakoc Y, et al. Clinical investigation of methotrexate in the treatment of ankylosing spondylitis. Scand J Rheumatol 2001;30:255-259.
  • Neri P, Zucchi M, Allegri P, et al. Adalimumab (Humi- raTM): a promising monoclonal anti-tumor necrosis factor alpha in ophthalmology. Int Ophthalmol 2011;31:165-173.
  • Braun J, Baraliakos X, Listing J, Sieper J. Decreased inci- dence of anterior uveitis in patients with ankylosing spondy- litis treated with the anti-tumor necrosis factor agents inflix- imab and etanercept. Arthritis Rheum 2005;52:2447-2451.

Ankilozan spondilit ile ilişkili üveit olgularında klinik seyir ve bulgular

Yıl 2013, Cilt: 40 Sayı: 3, 418 - 421, 01.09.2013
https://doi.org/10.5798/diclemedj.0921.2013.03.0301

Öz

Amaç: Ankilozan spondilit (AS) ile ilişkili üveit tanısı almış olguların klinik seyir ve bulgularının incelenmesi Yöntemler: Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi Göz Hastalıkları Anabilim Dalı, uvea birimi tarafından Mayıs 2009-Haziran 2012 tarihleri arasında AS ile ilişkili üveit tanısı almış olgular retrospektif olarak incelendi. Olguların sosyodemografik ve klinik özellikleri değerlendirildi. Bulgular: Toplam 13 hastanın 17 gözü çalışmaya dahil edildi. Olgular dokuz erkek (%69,2), dört kadından (%30,8) oluşmakta idi. Ortalama başvuru yaşları 38,54±9,61(28-63) yıl idi. Dört olguda iki taraflı tutulum (%30,8) tespit edildi. İzlem süreleri 17,46±11,86 ay (3-36 ay) idi. Ortalama atak sayısı 1,15±0,37(1-2) idi. Üç gözde (%17,6) ön üveite eşlik eden arka segment bulguları izlendi. Bir olguda (%7,7) arka yapışıklık, bir olguda (%7,7) katarakt, iki olguda (%15,4) kistoid makula ödemi, bir olguda epiretinal membran (%7,7) tespit edildi. Hastaların sonuç görme keskinlikleri ortalama 0,975±0,07 (0,2-1,0) olarak izlendi. Sonuç: AS ile ilişkili ön üveit olgularında zamanında ve doğru bir yaklaşım tarzı ile prognoz iyidir. Bu olgularda arka segment komplikasyonlarının da gelişebileceği unutulmamalı, tedavi ve takipleri romatoloji kliniği ile işbirliği içinde yapılmalıdır.

Kaynakça

  • Van der Linden S, Vonder Heide D, Braun J. Ankylosing spondylitis. In: Harris ED, editor. Kelley’s text book of rheumatology. 7th ed. 2006. p. 1125-1138.
  • Çalgüneri M. Ankilozan spondilit. İmmünoloji-Romatoloji Dergisi 2004;4:29-37.
  • Khan MA, Van der Linden SM. Ankylosing spondylitis and other spondylo artropathies. Rheum Dis Clin North Am 1990;16:551-579.
  • Rodriguez A. Calonge M, Pedroza-Seres M, et al. Refferal patterns of uveitis in a tertiary eye care center. Arch Oph- thalmol 1996;114:593-599.
  • Rothava A, vanVeenendaal WG, Lissen A, et al. Clini- cal features of acute anterior uveitis. Am J Ophthalmol 1987;103:137-145.
  • Rosembaum JT. Acute uveitis and spondyloarthropathies. Rheum Dis Clin North Am 1992;18:143-152.
  • Sampaio-Barros PD. Epidemiology of spondyloarthritis in Brazil. Am J Med Sci 2011;341:287-288.
  • Reveille JD, Ball EJ, Khan MA. HLA-B27 and genetic predisposing factors in spondyloarthropathies. Curr Opin Rheumatol 2001;13:265-272.
  • Chang JH, McCluskey PJ, Wakefield D. Acute anterior uve- itis and HLA-B27. Surv Ophthalmol 2005;50:364-388.
  • Zink A, Braun J, Listing J, Wollenhaupt J. Disability and handicap in rheumatoid arthritis and ankylosing spondy- litis - results from the German rheumatological database. German Collaborative Arthritis Centers. J Rheumatol 2000;27:613-622.
  • Mattey DL, Dawson SR, Healey EL, Packham JC. Rela- tionship between smoking and patient-reported measures of disease outcome in ankylosing spondylitis. J Rheumatol 2011;38:2608-2615.
  • Chung HY, Machado P, van der Heijde D, et al. Smokers in early axial spondyloarthritis have earlier disease onset, more disease activity, inflammation and damage, and poor- er function and health-related quality of life: results from the DESIR cohort. Ann Rheum Dis 2012;71:809-816.
  • Ündar L, Güler C, Işık O, ve ark. Akut anterior üveitte sakroileit sıklığı. Cumhuriyet Üniversitesi Tıp Fakültesi Dergisi 1988;10:1-2.
  • Bañares A, Hernández-García C, Fernández-Gutiérrez B, Jover JA. Eye involvement in the spondyloarthropathies. Rheum Dis Clin North Am 1998;24:771-784.
  • McCannel CA, Holland GN, Helm CJ, et al. Causes of uve- itis in the general practice of ophthalmology. Am J Ophthal- mol 1996;121:35-46.
  • Rodriguez A, Akova YA, Pedroza-Seres M, Foster CS. Posterior segment ocular manifestations in patients with HLA-B27-associated uveitis. Ophthalmology 1994;101:1267-1274.
  • Tay-Kearney ML, Schwam BL, Lowder C, et al. Clinical features and associated systemic diseases of HLA-B27 uve- itis. Am J Ophthalmol 1996;121:47-56.
  • Rothova A, van Veenedaal WG, Linssen A, et al. Clini- cal features of acute anterior uveitis. Am J Ophthalmol 1987;103:137-45.
  • Trevisani VF, Mattos KT, Esteves RF, et al. Auto antibod- ies specificity in acute anterior uveitis according to the presence of the HLA-B27 allele. Ocul Immunol Inflamm 2001;9:231-242.
  • Suhler EB, Martin TM, Rosenbaum JT. HLA-B-27-associ- ated uveitis: overview and current perspectives. Curr Opin Ophthalmol 2003;14:378-383.
  • Smith JR, Rosenbaum JT. Management of uveitis: a rheu- matologic perspective. Arthritis Rheum 2002;46:309-318.
  • Altan L, Bingol U, Karakoc Y, et al. Clinical investigation of methotrexate in the treatment of ankylosing spondylitis. Scand J Rheumatol 2001;30:255-259.
  • Neri P, Zucchi M, Allegri P, et al. Adalimumab (Humi- raTM): a promising monoclonal anti-tumor necrosis factor alpha in ophthalmology. Int Ophthalmol 2011;31:165-173.
  • Braun J, Baraliakos X, Listing J, Sieper J. Decreased inci- dence of anterior uveitis in patients with ankylosing spondy- litis treated with the anti-tumor necrosis factor agents inflix- imab and etanercept. Arthritis Rheum 2005;52:2447-2451.
Toplam 24 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Araştırma Yazıları
Yazarlar

Refik Oltulu Bu kişi benim

Hanife Yumak Erkoç Bu kişi benim

Günhal Şatırtav Bu kişi benim

Mehmet Okka Bu kişi benim

Yayımlanma Tarihi 1 Eylül 2013
Gönderilme Tarihi 2 Mart 2015
Yayımlandığı Sayı Yıl 2013 Cilt: 40 Sayı: 3

Kaynak Göster

APA Oltulu, R., Erkoç, H. Y., Şatırtav, G., Okka, M. (2013). Ankilozan spondilit ile ilişkili üveit olgularında klinik seyir ve bulgular. Dicle Medical Journal, 40(3), 418-421. https://doi.org/10.5798/diclemedj.0921.2013.03.0301
AMA Oltulu R, Erkoç HY, Şatırtav G, Okka M. Ankilozan spondilit ile ilişkili üveit olgularında klinik seyir ve bulgular. diclemedj. Eylül 2013;40(3):418-421. doi:10.5798/diclemedj.0921.2013.03.0301
Chicago Oltulu, Refik, Hanife Yumak Erkoç, Günhal Şatırtav, ve Mehmet Okka. “Ankilozan Spondilit Ile ilişkili üveit olgularında Klinik Seyir Ve Bulgular”. Dicle Medical Journal 40, sy. 3 (Eylül 2013): 418-21. https://doi.org/10.5798/diclemedj.0921.2013.03.0301.
EndNote Oltulu R, Erkoç HY, Şatırtav G, Okka M (01 Eylül 2013) Ankilozan spondilit ile ilişkili üveit olgularında klinik seyir ve bulgular. Dicle Medical Journal 40 3 418–421.
IEEE R. Oltulu, H. Y. Erkoç, G. Şatırtav, ve M. Okka, “Ankilozan spondilit ile ilişkili üveit olgularında klinik seyir ve bulgular”, diclemedj, c. 40, sy. 3, ss. 418–421, 2013, doi: 10.5798/diclemedj.0921.2013.03.0301.
ISNAD Oltulu, Refik vd. “Ankilozan Spondilit Ile ilişkili üveit olgularında Klinik Seyir Ve Bulgular”. Dicle Medical Journal 40/3 (Eylül 2013), 418-421. https://doi.org/10.5798/diclemedj.0921.2013.03.0301.
JAMA Oltulu R, Erkoç HY, Şatırtav G, Okka M. Ankilozan spondilit ile ilişkili üveit olgularında klinik seyir ve bulgular. diclemedj. 2013;40:418–421.
MLA Oltulu, Refik vd. “Ankilozan Spondilit Ile ilişkili üveit olgularında Klinik Seyir Ve Bulgular”. Dicle Medical Journal, c. 40, sy. 3, 2013, ss. 418-21, doi:10.5798/diclemedj.0921.2013.03.0301.
Vancouver Oltulu R, Erkoç HY, Şatırtav G, Okka M. Ankilozan spondilit ile ilişkili üveit olgularında klinik seyir ve bulgular. diclemedj. 2013;40(3):418-21.