Irritable Bowel Syndrome In Multiple Sclerosis Patients and Its Relation To Attacks

Yıl 2021, Cilt: 48 Sayı: 2, 253 - 259, 01.06.2021

Cem Bölük

https://doi.org/10.5798/dicletip.944374

Öz

Irritable Bowel Syndrome In Multiple Sclerosis Patients and Its Relation To Attacks

Öz

Abstract
Objective: Knowledge about bidirectional microbiome-gut-brain interactions has gradually increased in multiple sclerosis (MS) and many other diseases. The aim of this study is to determine the prevalence of irritable bowel syndrome (IBS) in MS patients, to compare with a control group and to identify the relationship between MS attacks and gastrointestinal (GI) symptoms.
Methods: Patients with at least a two-year diagnosis of relapsing-remitting MS (RRMS) from our outpatient clinic were included in the study. The duration of disease, expanded disability status scale and time of MS attacks were recorded. ROME- IV criteria were used for diagnosis of IBS. Results were compared with the control group. IBS symptoms prior to, during and after an attack were recorded and their relationship to MS attacks was investigated.
Results: 93 RRMS patients and 101 controls were included in this study. The prevalence rate of IBS was found to be 16.1% (n=15) in MS patients and 8.9% (n=9) in the control group. No significant difference can be found in IBS prevalence rate between MS patients and controls (p=0.127). MS attacks had no significant effect on constipation, diarrhea, abdominal pain and distention.
Conclusion: This study showed that MS patients have a similar IBS prevalence to the control group. In addition, MS attacks have no significant effect on GI symptoms.

Anahtar Kelimeler

Abdominal Pain, Constipation, Diarrhea, Irritable Bowel Syndrome, Multiple Sclerosis

Kaynakça

• 1.Marrie RA, Horwitz R, Cutter G, et al. Comorbiditydelays diagnosis and increases disability atdiagnosis in MS. Neurology 2009; 72: 117–24. doi:10.1212/01.wnl.0000333252.78173.5f.
• 2.Marrie RA, Rudick R, Horwitz R, et al. Vascularcomorbidity is associated with more rapid disabilityprogression in multiple sclerosis. Neurology 2010;74: 1041–7. doi: 10.1212/WNL.0b013e3181d6b125.
• 3.Köseoglu M, Gözübatik Çelik RG, Tütüncü M, ErbaşB.Quality of Life in Multiple Sclerosis: AreDepressive Findings as Effective as PhysicalDisability? Dicle Med J 2020; 47: 712-9. doi:10.5798/dicletip.800284.