REVIEW OF FACTORS ASSOCIATED WITH MORTALITY IN HIP FRACTURES

Öz

The incidence of hip fractures is increasing both worldwide and in our country. Mortality and morbidity rates related to this disease, which is generally reported to develop in elderly individuals, are still high despite advances in medical care and surgical techniques. This study provides an overview of the literature on mortality-related factors in hip fractures.

Anahtar Kelimeler

• Hip fracture
• mortality
• risk factors

KALÇA KIRIKLARINDA MORTALİTE İLİŞKİLİ FAKTÖRLERİN GÖZDEN GEÇİRİLMESİ

Öz

Kalça kırıklarının gerek dünya genelinde, gerekse de ülkemizde insidansı artmaktadır. Genellikle yaşlı bireylerde geliştiği bildirilen bu hastalığa bağlı mortalite ve morbidite oranları, tıbbi bakımdaki ve cerrahi tekniklerdeki ilerlemelere rağmen halen yüksek oranda saptanmaktadır. Bu çalışmada, kalça kırıklarında mortalite ilişkili faktörler konusundaki literatürün değerlendirilmesi konusunda genel bir bakış sunmaktadır.

Anahtar Kelimeler

• Kalça kırığı
• mortalite
• risk faktörleri

Kaynakça

1. 1. Fernandez MA, Griffin XL, Costa ML. Management of hip fracture. Br Med Bull. 2015;115(1):165-72.
2. 2. Johnell O, Kanis JA. An estimate of the worldwide prevalence, mortality and disability associated with hip fracture. Osteoporos. Int 2004; 15:897–902.
3. 3. Cooper C, Campion G, Melton LJ. Hip fractures in the elderly: a world-wide projection. Osteoporos Int. 1992; 2:285–9.
4. 4. Li L, Bennett-Brown K, Morgan C, Dattani R. Hip fractures. Br J Hosp Med (Lond). 2020;81(8):1-10.
5. 5. Tuzun S, Eskiyurt N, Akarirmak U, Saridogan M, Senocak M, Johansson H, Kanis JA; Turkish Osteoporosis Society. Incidence of hip fracture and prevalence of osteoporosis in Turkey: the FRACTURK study. Osteoporos Int. 2012;23(3):949-55.
6. 6. Dilsen G, Aydin R, Oral A, Sepici V, Alparsan B, Berker C, Aygün F, Erdogan F, Bölükbasi N, Cinar A, et al. Regional differences in hip fracture risk in Turkey. Bone. 1993;14 Suppl 1:S65-8.
7. 7. LeBlanc KE, Muncie HL Jr, LeBlanc LL. Hip fracture: diagnosis, treatment, and secondary prevention. Am Fam Physician. 2014;89(12):945-51.
8. 8. Koseki H, Sunagawa S, Noguchi C, Yonekura A, Matsumura U, Watanabe K, Nishiyama Y, Osaki M. Incidence of and risk factors for hip fracture in Nagasaki, Japan from 2005 to 2014. Arch Osteoporos. 2021;16(1):111.

9. 9. Kristensen MT, Bandholm T, Bencke J, Ekdahl C, Kehlet H. and Knee-extension strength, postural control and function are related to fracture type and thigh edema in patients with hip fracture. Clin Biomech (Bristol, Avon). 2009; 24: 218– 24.
10. 10. Mitchell SL, Stott DJ, Martin BJ, Grant SJ. Randomized controlled trial of quadriceps training after proximal femoral fracture. Clin Rehabil. 2001;15(3):282-90.
11. 11. Ramponi DR, Kaufmann J, Drahnak G. Hip Fractures. Adv Emerg Nurs J. 2018;40(1):8-15.
12. 12. Pejic A, Hansson S, Rogmark C. Magnetic resonance imaging for verifying hip fracture diagnosis why, when and how? Injury. 2017;48(3):687-91.
13. 13. Roberts SE, Goldacre MJ. Time trends and demography of mortality after fractured neck of femur in an English population, 1968–98: database study. BMJ. 2003; 327:771–5.
14. 14. Griffin XL, Parsons N, Achten J, Fernandez M, Costa ML. Recovery of health-related quality of life in a United Kingdom hip fracture population. The Warwick Hip Trauma Evaluation--a prospective cohort study. Bone Joint J. 2015;97-B (3):372-82.
15. 15. Brunskill SJ, Millette SL, Shokoohi A, Pulford EC, Doree C, Murphy MF, Stanworth S. Red blood cell transfusion for people undergoing hip fracture surgery. Cochrane Database Syst Rev. 2015;(4):CD009699.
16. 16. McDonough CM, Harris-Hayes M, Kristensen MT, Overgaard JA, Herring TB, Kenny AM, Mangione KK. Physical Therapy Management of Older Adults With Hip Fracture. J Orthop Sports Phys Ther. 2021;51(2): CPG1-CPG81.
17. 17. Leibson CL, Tosteson AN, Gabriel SE, Ransom JE, Melton LJ. Mortality, disability, and nursing home use for persons with and without hip fracture: a population-based study. J Am Geriatr Soc. 2002;50(10):1644-50.
18. 18. Magaziner J, Lydick E, Hawkes W, Fox KM, Zimmerman SI, Epstein RS, Hebel JR. Excess mortality attributable to hip fracture in white women aged 70 years and older. Am J Public Health. 1997;87(10):1630-6.
19. 19. Ribeiro TA, Premaor MO, Larangeira JA, Brito LG, Luft M, Guterres LW, et al. Predictors of hip fracture mortality at a general hospital in South Brazil: An unacceptable surgical delay. Clinics (Sao Paulo). 2014; 69(4): 253-8.
20. 20. Pereira SR, Puts MT, Portela MC, Sayeg MA. The impact of prefracture and hip fracture characteristics on mortality in older persons in Brazil. Clin Orthop Relat Res. 2010; 468(7): 1869-83.
21. 21. Ricci G, Longaray MP, Gonçalves RZ, Ungaretti Neto AS, Manente M, Barbosa LBH. Avaliação da taxa de mortalidadeem um ano após fratura de quadril e fatores relacionados àdiminuição da sobrevida no idoso. Rev Bras Ortop. 2012; 47(3): 304-9.
22. 22. Pallardo Rodil B, Gómez Pavón J, Menéndez Martínez P. Hip fracture mortality: Predictive models. Med Clin (Barc). 2020;154(6):221-31.
23. 23. Xu BY, Yan S, Low LL, Vasanwala FF, Low SG. Predictors of poor functional outcomes and mortality in patients with hip fracture: a systematic review. BMC Musculoskelet Disord. 2019;20(1):568.
24. 24. Magaziner J, Lydick E, Hawkes W, Fox KM, Zimmerman SI, Epstein RS, Hebel JR. Excess mortality attributable to hip fracture in white women aged 70 years and older. Am J Public Health. 1997;87(10):1630-6.
25. 25. Riggs BL, Melton LJ 3rd. The worldwide problem of osteoporosis: insights afforded by epidemiology. Bone. 1995;17(5 Suppl):505S-511S.
26. 26. Thingstad P, Egerton T, Ihlen EF, Taraldsen K, Moe-Nilssen R, Helbostad JL. Identification of gait domains and key gait variables following hip fracture. BMC Geriatr. 2015; 15:150.
27. 27. Smith T, Pelpola K, Ball M, Ong A, Myint PK. Pre-operative indicators for mortality following hip fracture surgery: a systematic review and meta-analysis. Age Ageing. 2014;43(4):464-71.
28. 28. Kua J, Ramason R, Rajamoney G, Chong MS. Which frailty measure is a good predictor of early post-operative complications in elderly hip fracture patients? Arch Orthop Trauma Surg. 2016; 136(5):639-47.
29. 29. Lin HS, Watts JN, Peel NM, Hubbard RE. Frailty and post-operative outcomes in older surgical patients: a systematic review. BMC Geriatr. 2016;16(1):157.
30. 30. Krishnan M, Beck S, Havelock W, Eeles E, Hubbard RE, Johansen A. Predicting outcome after hip fracture: using a frailty index to integrate comprehensive geriatric assessment results. Age Ageing. 2014;43(1):122-6.
31. 31. Guzon-Illescas O, Perez Fernandez E, Crespí Villarias N, Quirós Donate FJ, Peña M, Alonso-Blas C, García-Vadillo A, Mazzucchelli R. Mortality after osteoporotic hip fracture: incidence, trends, and associated factors. J Orthop Surg Res. 2019;14(1):203.
32. 32. Fransen M, Woodward M, Norton R, Robinson E, Butler M, Campbell AJ. Excess mortality or institutionalization after hip fracture: men are at greater risk than women. J Am Geriatr Soc. 2002;50(4):685-90.
33. 33. Johnell O, Kanis JA, Odén A, Sernbo I, Redlund-Johnell I, Petterson C, De Laet C, Jönsson B. Mortality after osteoporotic fractures. Osteoporos Int. 2004;15(1):38-42.
34. 34. Aharonoff GB, Koval KJ, Skovron ML, Zuckerman JD. Hip fracture in the elderly: Predictors of one year mortality. J Orthop Trauma. 1997; 11(3): 162-5.
35. 35. Endo Y, Aharanoff GB, Zuckerman JD, Egol KA, Koval KJ. Gender differences in patients with hip fracture: A greater risk of morbidity and mortality in men. J Orthop Trauma. 2005; 19(1): 29-35.
36. 36. Pugely AJ, Martin CT, Gao Y, Klocke NF, Callaghan JJ, Marsh JL. A risk calculator for short-term morbidity and mortality after hip fracture surgery. J Orthop Trauma. 2014; 28(2): 63-9.
37. 37. Astur DC, Arliani GG, Balbachevsky D, Fernandes HJ, Reis FB. Fraturas da extremidade proximal do fêmur tratadas no Hospital São Paulo/Unifesp - Estudo epidemiológico. RBM Espec Ortop. 2011; 68(4): 11-5.
38. 38. Daugaard CL, Jorgensen HL, Riis T, Lauritzen JB, Duus BR, vander Mark S. Is mortality after hip fracture associated with surgical delay or admission during weekends and public holidays? A retrospective study of 38,020 patients. Acta Orthop. 2012; 83(6): 609-13.
39. 39. Khan SK, Rushton SP, Dosani A, Gray AC, Deehan DJ. Factors influencing length of stay and mortality after first and second hip fractures: An event modeling analysis. J Orthop Trauma. 2013; 27(2): 82- 6.
40. 40. Baker DM. Postoperative complications and mortality associated with operative delay in older patients who have a fracture of the hip. J Bone Joint Surg Am. 1997; 79(3): 470.
41. 41. Guerra MTE, Viana RD, Feil L, Feron ET, Maboni J, Vargas ASG. One-year mortality of elderly patients with hip fracture surgically treated at a hospital in Southern Brazil. Revista Brasileira de Ortopedia. 2017; 52(1): 17-23.
42. 42. Rodgers A, Walker N, Schug S, McKee A, Kehlet H, Van Zundert A, et al. Reduction of postoperative mortality and morbidity with epidural or spinal anaesthesia: results from overview of randomised trials. Bmj. 2000;321(7275):1493.
43. 43. Neuman MD, Silber JH, Elkassabany NM, Ludwig JM, Fleisher LA. Comparative effectiveness of regional versus general anesthesia for hip fracture surgery in adults. Anesthesiology: The Journal of the American Society of Anesthesiologists. 2012;117(1):72-92.
44. 44. Saricaoğlu F, Akinci SB, Atay S, Çağlar Ö, Aypar Ü. Femur kiriği nedeni ile opere olan yaşli hastalarda anestezi tekniklerinin postoperatif mortaliteye etkisinin retrospektif olarak incelenmesi. Turk Geriatri Derg. 2012;15(4):143-50.
45. 45. Vestergaard P, Rejnmark L, Mosekilde L: Increased mortality in patients with a hip fracture-effect of pre-morbid conditions and post-fracture complications. Osteoporos Int. 2007;18:1583–93.
46. 46. Heidari SM, Soltani H, Hashemi SJ, Talakoub R, Soleimani B. Comparative study of two anesthesia methods according to postoperative complications an done month mortality rate in the candidates of hip surgery. J Res Med Sci 2011;16:323–30.
47. 47. González-Rozas M, Pérez-Castrillón JL, González-Sagrado M, Ruiz-Mambrilla M, García-Alonso M. Risk of mortality and predisposing factors after osteoporotic hip fracture: a one-year follow-up study. Aging Clin Exp Res. 2012;24:181–7.
48. 48. Kopp L, Edelman K, Obruba P, Prochazka B, Blstakova K, Dzupa V. Mortality risk factors in the elderly with proximal femoral fracture treated surgically. Acta Chir Orthop Traumatol Cech. 2009;76:41–6.
49. 49. Chatterton B. D, Moores T. S, Ahmad S, Cattell A, Roberts P. J. Cause of death and factors associated with early in-hospital mortality after hip fracture. The Bone and Joint Journal. 2015;97:246–51.
50. 50. Hossain M, Andrew JG. Is there a difference in perioperative mortality between cemented and uncemented implants in hip fracture surgery? Injury. 2012;43(12):2161-4.
51. 51. Talsnes O, Vinje T, Gjertsen J. E, Dahl O. E, Engesaeter L. B, Baste V, Pripp A. H, Reikeras O. Perioperative mortality in hip fracture patients treated with cemented and uncemented hemiprosthesis: a registerstudy of 1,210 patients. International Orthopaedics (SICOT). 2013; 37:1135–40.
52. 52. Giversen IM. Time trends of mortality after first hip fractures. Osteoporos Int. 2007;18:721–32.
53. 53. Karagiannis A, Papakitsou E, Dretakis K, Galanos A, Megas P, Lambiris E,Lyritis GP: Mortality rates of patients with a hip fracture in a South Western district of Greece: ten-year follow-up with reference to thetype of fracture. Calcif Tissue Int. 2006;78:72–7.
54. 54. Oztürk I, Toker S, Ertürer E, Aksoy B, Seçkin F. Kalça kırığı nedeniyle ameliyat edilen 65 yaş üstü hastalarda mortaliteye etki eden risk faktörlerinin değerlendirilmesi. Acta Orthop Traumatol Turc. 2008;42(1):16-21.
55. 55. Turhan Y, Arıcan M. Kalça Kırığı Nedeniyle Cerrahi Tedavi Uygulanan 65 Yaş Üstü Hastaların Bir Yıllık Mortalite Oranları. Düzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi. 2019; 9(2): 57-60.
56. 56. Yaradılmış YU, Okkaoğlu MC, Ateş A, Kılıç A, Demirkale İ, Altay M. Proximal femur fracture, analysis of epidemiology, complications, and mortality: A cohort with 380 patients. J Surg Med. 2021; 5(1): 75-9.
57. 57. Elmas U, Yurtlu BS, Küçükosman G, Pişkin Ö, Okyay RD, Hanci V, et al. Kalça kiriği operasyonlarinda mortalite ve morbiditeye etki eden nedenler: retrospektif bir değerlendirme. Haydarpaşa Numune Eğitim ve Araştırma Hastanesi Tıp Dergisi. 2015;55(3):179-213.
58. 58. Atay T, Ceylan B, Özmeriç A, Eroğlu F, Yavuz L, Heybeli N. The effects of related factors on one-and two-year mortality after a hip fracture in elderly Turkish patients. Trakya Univ Tip Fak Derg. 2010;27(2):127-131.
59. 59. Güler A, Doğukan M, Kaya R, Uludağ Ö, Tutak A, Duran M. Kalça Kırığı sebebiyle Ameliyat Olmuş Yaşlı Hastalarda Albumin ve Hemoglobin Değerlerinin Hastanede Kalış Süresi ve Mortalite Üzerine Etkisinin Retrospektif İncelenmesi. ADYÜ Sağlık Bilimleri Derg. 2018; 4(1): 637-47.
60. 60. Kuyubaşı SN, Demirkiran ND, Kozlu S, Öner SK. Covid-19 pozitif kalça kırığı olan hastalarda cerrahi sonrası mortalite artar. Turk J Hip Surg. 2021;1(3):78-83.
61. 61. Karaman Ö, Özkazanlı G, Orak MM, Mutlu S, Mutlu H, Çalışkan G, Karakuş Ö, Saygı B. Factors affecting postoperative mortality in patients older than 65 years undergoing surgery for hip fracture. Ulus Travma Acil Cerrahi Derg. 2015;21(1):44-50.
62. 62. Kilci O, Un C, Sacan O, Gamli M, Baskan S, Baydar M, Ozkurt B. Postoperative Mortality after Hip Fracture Surgery: A 3 Years Follow Up. PLoS One. 2016;11(10):e0162097.