EFFECTS OF LOW DOSE IONIZING RADIATION ON BLOOD SERUM LİPİD AND THYROID HORMONE LEVELS OF THE RADIOLOGY WORKERS

Öz

This study aimed to investigate the effect of occupational exposures to long term low-dose ionizing radiation on blood serum lipid and thyroid hormone levels of the radiology workers. Private and state hospitals at Kütahya centrum age range of working group was 21-48 with average age of 33.86 years (24 for women and 22 for men) 46 working in the department of radiology were enrolled to this study. In the control group the age range was 22-29 with average age of 33.83 years (20 for women and 18 for men) but control group has not exposed to radiation. Total cholesterol, triglycerides and LDL-cholesterol levels were significantly higher (p<0.05), HDL-cholesterol levels were lower in the radiology workers compared to the control group. FT3 and FT4 levels were significantly lower (p<0.05), TSH levels were higher. In radiology workers were determined exposed to long-term low-dose ionizing radiation, blood cholesterol levels were higher. FT3 and FT4 levels were lower, TSH levels were higher.

 

Anahtar Kelimeler

• : Radiology workers,ionizing radiation,serum lipid,thyroid hormone

DÜŞÜK DOZ İYONİZE RADYASYONUN RADYOLOJİ ÇALIŞANLARININ TİROİD HORMONLARI VE SERUM KOLESTEROL SEVİYELERİ ÜZERİNE ETKİSİ

Öz

Mesleki olarak iyonize radyasyona uzun süre maruz kalan radyoloji çalışanlarında, uzun süreli düşük doz iyonize radyasyonun, kan serum lipid ve tiroid hormon düzeylerine etkisinin incelenmesi amaçlandı. Kütahya merkezdeki devlet ve özel hastanelerinde yaşları 21-48 (33,71 ± 7,88 yıl)  arasında değişen 24’ü kadın ve 22’si erkek toplam 46 radyoloji departmanı çalışanı çalışmamıza dahil edildi. Kontrol grubu radyasyona maruz kalmayan yaşları 22-49 (33,42 ± 6,12) 20’si kadın 18’i erkek 38 sağlıklı kişiden oluşturuldu. Kontrol grubuyla kıyaslandığında radyoloji çalışanlarında; total kolesterol, trigliserid ve LDL-kolesterol düzeylerinin anlamlı olarak yüksek olduğu HDL-kolestrol düzeylerinin anlamlı olmamakla birlikte düşük olduğu saptandı. Tiroid fonksiyonları bakımından da FT3 ve FT4 düzeylerinin anlamlı derecede düşük olduğu, TSH düzeylerinin anlamlı olmasa da yüksek olduğu saptandı. Uzun dönem düşük doz iyonize radyasyona maruz kalan radyoloji çalışanlarında, kan kolesterol düzeylerinin yükseldiği tespit edilmiştir. FT3 ve FT4 düzeylerinin düştüğü, TSH düzeylerinin yükseldiği tespit edilmiştir.

 

Anahtar Kelimeler

• : Radyoloji çalışanları,iyonize radyasyon,serum lipid,tiroid hormon

Kaynakça

1. [1] Health risks from exposure to low levels of ionizing radiation- BEIR VII. Washington DC: National Academies Press, (2005).
2. [2] S.K. Soldatov, I.B. Ushakov, “Low doses of ionizing radiation and short- and long-term hematologic changes”, Med. Tr. Prom. Ekol, 9, 20-23 (1995).
3. [3] H. Engler, W.F. Riesen, “Effect of thyroid function on concentration of lipoprotein”, Clin. Chem, 39(12), 2466-2469 (1993).
4. [4] F.M. Ruggiero, F. Cafagno, E. Quagliariello, “Exchange of free cholesterol between plasma and erythrocytes from hyperthyroid and hypothyroid rats in vivo”, Lipids, 25(9), 529-533 (1990).
5. [5] R.L. Gebhard, B.G. Stone, J.P. Andreini, W.C. Duane, C.D. Evans, W. Prigge, “Thyroid hormone differentially augments biliary sterol secretion in the rat”, “I. The isolated-perfused liver model”, J. Lipid. Res, 33, 1459-1466 (1992).
6. [6] J.H. Sellin, R. Vasilopoulou-Sellin, “The gastrointestinal tract and liver in hypothyroidism”, L.E. Brauerman, R.D.Utiger, Werner&Ingbar’s the Thyroid: A fundamental and clinical text. 8th. ed. Philadelphia, Lippincott Williams&Wilkins, 795-799 (2000).
7. [7] PP Chaialo, GM Chobat'ko, IV Shimelis, BP Prevarskii: Content of blood lipids and charecteristics of dyslipoproteinemias in people exposed to radiation during the accident at the Chernobyl nuclear povver station. Ukrainskii Biokhimicheskii Zhurnal 63:93-96, 1991.
8. [8] P.P. Chaialo, N.N. Lialhovchuk, G.M. Chobat'ko, P.A. Voziian, I.U.D. Kholodova, “The composition and physicochemical properties of the blood lipoproteins in rats exposed to external gamma irradiation”, Ukrainskii Biokhimicheskii Zhurnal, 64, 26-32 (1992).

9. [9] Q. Zhang, J.Z. Hu, D.N. Rommereim, M.K. Murphy, R.P. Phipps, D.L. Huso, J.F. Dicello, “Application of high resolution 1H MAS NMR spectroscopy to the analysis of intact bones from mice exposed to gamma radiation”, Radiat. Res, 172(5), 607-616 (2009).
10. [10] S. Serhatlıoğlu, A.T. Ozan, F. Gürsu, A. Gödekmerdan, A. Ayar, E. Oğur, “İyonizan radyasyonun radyoloji çalışanlarının Bağışıklık düzeyleri ve kan biyokimyası üzerine etkileri”, Tanısal ve Girişimsel Radyoloji, 10, 97-102 (2004).
11. [11] H. Karagül, A. Altıntaş, U.R. Fidancı, T. Sel, “Klinik Biyokimya 1. Baskı”, Medisan, Ankara, (2000).
12. [12] T.M. Gueorguıeva, and I.P. Gueorguıev, “Serum cholesterol concentration around parturition and in early lactation in dairy cows”, Rev. Med. Vet, 148, 241-244 (1989).
13. [13] M.G. Larsson, “Determination of free thyroxine and cholesterol as a new screening test for canine hypothyroidism”, J. Amer. Anim. Hosp. Assoc, 24, 209-217 (1988).
14. [14] S. Valdermarsson, P. Hansson, P. Hedner, P. Nılsson-Ehle, “Relations between thyroid function hepatic and lipoprotein lipase activities and plasma lipoprotein concentrations”, Acta. Endocrinol, 104, 50-56 (1983).
15. [15] R.E. Übrahim, M.A. Maglad, S.E.I. Adam, T.E. Mirghani, I.A. Wasfi, “The effect of altered thyroid status on lipid metabolism in nubian goats”, Comp. Biochem. Physiol, 77, 507-512 (1984).
16. [16] A.E. Hak, H.A.P. Pols, T.J. Visser, H.A. Drexhage, A. Hofman, J.C.M. Witteman, “Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women”, The Rotterdam Study, Ann. Intern. Med, 132, 270-278 (2000).
17. [17] S. Miura, M. Litaka, H. Yoshimura, et al. “Disturbed lipid metabolism in patients with subclinical hypothyroidism Effect of L-thyroxine therapy”, Internal. Medicine, 33, 413-417 (1994).
18. [18] G.J. Canaris, N.R. Manowitz, G. Mayor, E.C. Ridgway, “The Colorado thyroid disease prevalence study”, Arch. İntern. Med, 160, 526-534 (2000).