BİTKİ ÖZÜTLERİNİN STRES, HİPERGLİSEMİ, HİPERLİPİDEMİ VE HİPERKOLESTEROLEMİ SEVİYELERİ ÜZERİNE OLAN ETKİLERİ

Öz

Bu çalışmada, bitki özütlerinin stres, hiperglisemi, hiperlipidemi ve hiperkolesterolemi üzerine etkilerini araştıran çalışmaları derlemek ve biyodeney ünitemizden elde ettiğimiz tecrübeleri sunmak amaçlanmıştır. Sonuç olarak birçok bitki özütünün stres, hiperglisemi, hiperlipidemi ve hiperkolesterolemi tedavilerinde kullanılan ilaçlar kadar etkili olduğu belirlenmiştir.

Anahtar Kelimeler

• Bitki Özütleri,Hiperglisemi,Hiperlipidemi,Hiperkolesterolemi,Stres

EFFECT OF HERB EXTRACTS ON STRESS, HYPERGYLICEMIA, HYPERLIPIDEMIA AND HYPERCHOLESTEROLEMIA LEVELS

Öz

The aim of this study was to review the articles which investigate the effect of herb extracts on stress, hyperglycemia, hyperlipidemia and hypercholesterolemia levels and to present our experience of bioexperiment unit. As a result, many herb extracts found that effect on treatment of stress, hyperglycemia, hyperlipidemia and hypercholesterolemia as pharmacological drugs.

Anahtar Kelimeler

• Herb extracts
• Hyperglycemia
• Hyperlipidemia
• Hypercholesterolemia
• Stress

Kaynakça

1. [1] Natelson, B.H., 2004. Stress, hormones and disease, Physiol. Bahev., 82, 139-143 p.
2. [2] Ricart-Jané, D., Rodríguez-Sureda, V., Benavides, A., Peinado-Onsurbe, J., López- Tejero, M.D. and Llobera, M., 2002. Immobilization stres alters intermediate metabolism and circulating lipoproteins in rat, Metabolism, 51, 7, 925-931 p.
3. [3] Suzuki, H. and Rhim, J.H., 2000. Effect of samgyetang feeding on plazma lipids, glucose, glycosylated hemoglobin and stress induced gastric ulcers in mice, Nutrition Research, 20, 4, 575-584 p.
4. [4] Vermetten, E., Vythilingam, M., Southwick, S.M., Charney, D.S. and Bremmer, J. D., 2003. Long-term treatment with paroxetine increases verbal declarative memory and hippocampal volume in posttraumatic stress disoder, Biol. Psychiatry, 54, 693-702 p.
5. [5] Gnosh, P. R., Sahv, A. and Maiti, B. R., 1983. Leucocyte responses to fighting in the adult male bandicoot rat, Acta Anat. , 115, 263-265 p.
6. [6] Silberman, D. M., Wald, M. R. and Genaro, A. M., 2003. Acute and chronic stress exert opposing effect on antibody responses associated with changes in stress hormone regulation of T-lymphocyte reactivity, Journal of Neuroimmunology, 144, 53-60 p.
7. [7] Kalantaridou, S. N., Makrigiannakis, A., Zoumakis, E. and Chrousos, G. P., 2004. Stress and the female reproductive system, Journal of Reproductive Immunology 62, 61-68 p.
8. [8] Puvadolpirod, S. and Thaxton, J. P., 2000. Model of physiological stress in chikens 2. Dosimetry of adrenocorticotropin, Poult. Sci. , 79, 3, 370-376 p.

9. [9] Ortuño, J., Esteben, M.E. and Meseguer, J., 2002. Effects of phenoxyethanol on the innate immune system of gilthead seabream (Sparus aurata L.) exposed to crowding stress, Veterinary Immunology and Immunopathology, 89, 29-36 p.
10. [10] Bağrıaçık, N., 2003. Diabetin Sağlık Ekonomisi ve Mali Yükü. Türk Diyabet Cemiyeti Diyabet Dergisi, Yıl:5, Sayı:18, Sayfa:8-9.
11. [11] Yenson, M.,1988. İnsan biyokimyası (Geliştirilmiş 6. baskı) Beta basın yayın dağıtım, İstanbul 837s.
12. [12] Guyton A.C. 1978. Fizyoloji (Çev. A., Kazancıgil). Güven kitabevi Ankara, 3, 564s.
13. [13] Grover, J.K., Vats, V., Rathi, S. S., 2000. Antihyperglycemic effect of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolik enzymes involved in carbonhydrate metabolism.Journal of Ethnopharmacology 73 , 461-470.
14. [14] Sepici, A., 2000. Türkiye’de Halk Arasında Diabetes Mellitus Hastalığının Tedavisinde Kullanılan Mersin Uçucu Yağı (Myrtıı oleum) Üzerine Biyokimyasal Çalışmalar. Doktora Tezi, Gazi Üniversitesi Sağlık Bilimleri Enstitüsü, Ankara, 121 sayfa.
15. [15] Ruxue Zhang, Sinhuang Zhou, Zihengping Jia, Yang Xiang Zhong, Guoming Gu, 2004. Hypoglycemic effect of Rehmamra glutinosa oligosaccharide in hyperglicemic and alloksan-induced diabetic rats and its mechanism.Journal of Ethnapharmacology 90, 39-43.
16. [16] Kamalakkonon, N., P. Stanely Mainzen Prince, 2003. Hypoglicemic effect of water extracts of Aegle marmelosum fruits in STZ diabetic rats.Journal of Ethnopharmacology 87 , 207-210.
17. [17] Olusolo Ladeji, Ikechukwu Omekarah, Moriam Solamon, 2003. Hypoglisemic properties of aquoeus extract of Ceiba pentondra in STZ induced diabetic rats.Journal of Ethnopharmacology 84, 139-142.
18. [18] Gallangher, A. M., P. R. Flatt, 2003. The effect of traditional antidiabetik plants on invitro glukose diffusion.Nutrition Research 23, 413-424.
19. [19] John A. O., 2002. Hyperglicemic effect of Clausena anisoto (wild) hook methanolic root extract in rats.Journal of Ethnopharmacology 81, 231-237.
20. [20] Perfumi, M., Arnold, N., Tacconi, R., 1991. Hypoglycemic activity of Salvia fruticosa Mill. From Cyprus, J. Ethnopharmacology 34, p 135- 140.
21. [21] Homdy A. Monsour, 2002. Biochemical study on effect of soma Egyptian herbs in alloksan-induced diabetic rats.Toxicology 170, 221-228.
22. [22] Vats, V., Graver J.K. and Rathi, S.S., 2002. Evaluation of antihyperglicemic and hypoglicemic effect of Trigonella foenum graecum Linn.,Ocium sanctum Linn. and Pterecarpus marsupium Linn. in normal and alloxanized diabetik rats.Journal of Ethnopharmacology 79, 95-100.
23. [23] Ziyyot, A. and et all, 1997. Phytoteraphy at hypertansion and diabetes oriental Morocco.Journal of Ethnopharmacology 58(1),45-54.
24. [24] Kamel M.S., Ohtani K., Kurukava T., Assat M.H., El-Shanawany M.A., Ali A.A., 1991. Studies on Belonites aegyptiaca fruits on diabetic Egyptian folk medicine.Chemistry Pharmacology Bulltein.35(5),1229-1233.
25. [25] Medina F.S., Gamez M.J., Jimnez I., Jimenez J., Osuna J.I., Zarzuelo A., 1994. Hypoglicemic activity of Juniper berris.Planta Med.,60, 197-200.
26. [26] Phelps, S. and Haris, W.S., 1993. Garlic supplemantation lipoprotein oxidation susceptibiliyt, Lipids, 28, 475-477
27. [27] Mathur, R., Sharma, A., Dixit, V.P. and Varma, M., 1996. Hypolipidemic effect of fruit juice of Emblica officinalis in cholesterol fed rabbits, Journal of Ethnopharmocology, 50, 2, 61-68.
28. [28] Mai Le, P., Andaloussi, A.B., Elimadi, A., Settaf, A., Cherrah, Y., Haddad, P.S., 2004. The petroleum ether extract of Nigelle sativa exerts lipid-lowering and insulinsensitizing actions in the rat, Journal of Ethnopharmocology, 94, 251-259.
29. [29] Bolkent, S., Yanardag, R., Bulan, O.K., Yesilyaprak, B., 2005. Protective role of Mrlissa officinalis L. Ekstract on liver of hyperlipidemic rats: A morphological and biochemical study, Journal of Ethnopharmocology, 99, 391-398.
30. [30] Mukhopadyay, S., Mondal, A. and Poddar, M. K., 2003. Chronic administration of caffein: effect on the activities of hepatic antioxidant enzymes of Ehrlich ascites tumor-bearing mice, İndian. J. Exp. Biol. , 41, 4, 283-289 p.
31. [31] Sendl, A., Schliack, M., Löser, R., Stanislaus, F., and Wagner, H., 1992. İnhibition of cholesterol synthesis in vitro by extracts and isolated compounds prepared from garlic and wild garlic. Atheroscklerosis 94, 79-95.
32. [32] Johnston, T.P., Nguyen, L.B., Chu, W.A., Shefer, S. 2001. Potency of select statin drugs in a new Mouse model of hiperlipidemia and atherosclerosis International Journal of Phermaceutics, 229, 75-86.
33. [33] Jain, A.K., Vargas, R., Gotzkowsky, S., Macmahon, F.G., 1993. Can garlic reduce levels of serum lipids? A contralled clinical study, The American Journal of medicine, 94, 6, 632-635.
34. [34] Murakami, S., Ohta, Y. K. and Tomisawa, K., 1999. Improvement in cholesterol metabolism in mice given chronic treatment of taurine and fed a high-fat diet, 64, 1, 83-91 p.
35. [35] Somova, L.I., Shode, F.O., Ramnanan, P., Nadar, A., 2003. Antihypertensive, antiatherosclerotic and antioxidant activity of triterpenoids isolated from Olea europaea, subspecies africana leaves, Journal of Ethnopharmacology, 84, 299-305
36. [36] Bennani-Kabchi, N., Fdhil, H., Cherrah, Y., El Bouayadi, F., Kehel, L., Marqui, G., 2000. Therapeutic effect of Olea europaea var. Oleaster leaves on carbonhydrate and lipid metabolismin obese and prediabetic sand rats (Psammomys obesus), Ann. Pharm. Fr., 58(4): 271-279
37. [37] Sharma A., Mathur R., Dixit VP., 1995. Hypocholesterolemic activity of nut shell extract of, Semecarpus anacardium (Bhilawa) in cholesterol fed rabbits, Indian J Exp Biol., 33(6), 444-448.
38. [38] Fki, I., Bouaziz, M., Sahnoun, Z. and Sayadi, S., 2005. Hypocholesterolemic effects of phenolic-rich extracts of Chamlali olive cultivar in rats fed a cholesterol-rich diet, Bioorganic and Medicinal Chemistry, 13, 5362-5370.
39. [39] Özbek, H., Uğraş, S., Dülger, H., Bayram, İ., Tuncer, İ., Öztürk, G. and Öztürk, A., 2003. Hepatoprotective effect of Foeniculum vulgare essantial oil, Fitoterapia, 74, 3, 317-319 p.
40. [40] Sadraei, H., Ghannadi, A. and Malekshahi, K., 2003. Relaxant effect of essantial oil of Melissa officinalis and citral on rat ileum contractions, Fitoterapia, 74, 5, 445-452 p.
41. [41] Oktay, M., Gül, İ. and Küfrevioğlu, Ö. İ., 2003. Determination of in-vitro antioxidant activity of fennel (Foeniculum vulgare) seed extracts, Lebensmittel- Wissenschaft und-Tecnologie, 36, 2, 263-271 p.
42. [42] Wake, G., Court, L., Pickering, A., Lewis, R., Wilkins, R. and Perry, E., 2000. CNS acetylcholine receptor activity in European medicinal plants traditionally used to improve failing memory, Journal of Ethnopharmacology, 69, 2, 105-114 p.
43. [43] Stevinson, C. and Ernst, E., 2000. Valerian for insomnia: a systematic rewiev of randomized clinical trials, Sleep Medicine, 1, 91-99 p.
44. [44] Abdul-Ghani, A.–S. and Amin, R., 1988. The vascular action of aqueous extracts of Foeniculum vulgare leaves, Journal of Ethnopharmacology, 24, 2-3, 213-218 p.
45. [45] Hendriks, H., Bos, R., Woerdenbag, H. J. and Koster, A. S., 1985. Central nervous depressant activity of valerenic acid in the mouse, Planta Med. , 51, 28-31 p.
46. [46] P. Stanely Mainzen Prince, N. Kamalakkonon, Venuqopol P. Menon, 2003. Syzigium comini seed extracts reduce tissue damage in diabetic rat brain.Journal of Ethnopharmacology 84, 205-209.
47. [47] Özay Y. 2004. Isırgan otu (Urtica drasca), zeytin yaprağı (Olea europeae), ökaliptus (Eucalyptus globulus) ve ökse otu (Viscum album)’nun alloksan ile hiperglisemi edilmiş erkek fareler (Mus musculus)’in kan ve karaciğerlerindeki glikoz seviyelerine etkileri, Yüksek Lisans Tezi, Kütahya.
48. [48] Dayıoğlu S. 2005. Stresli fareler (Mus musculus)’in beyin ve karaciğerlerindeki toplam lipid ve toplam glukoz seviyelerine paxil, kedi otu (Valeriana officinalis), rezene (Foeniculum vulgare) ve oğul otu (Melissa officinalis)’nun etkileri, Yüksek Lisans Tezi, Kütahya.
49. [49] Yılmaz H. 2005. Bazı bitki özütlerinin erkek fareler (Mus musculus)’in kan ve iç organlarındaki toplam lipid ve top lam kolesterol seviyelerine etkileri, Yüksek Lisans Tezi, Kütahya.