SYNTHESIS AND CHARACTERISATION OF SOME ESTER, AMIDE AND UREIDE DERIVATIVES OF 4-(ETHOXYCARBONYL)-1-(3-NITROPHENYL)-5-PHENYL-1H-PYRAZOLE-3-CARBOXYLIC ACID

Yıl 2011, Sayı: 026, 47 - 56, 15.12.2011

Rahmi Kasımoğulları , Hamdiye Duran Samet Mert

Öz

In this study, some new derivatives were synthesized of 4-(ethoxycarbonyl)-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid (1) which was a pyrazole carboxylic acid
derivative. For this aim, ester derivatives were obtained from the reaction of 1 with various alcohols; amide (7) and ureide (8) derivatives were obtained from the reaction with amonnia and
urea respectively. Also a new pyrazole derivative (9) was synthesized from decarboxylation of 1. The structures of synthesized compounds were elucidated with FT-IR,
¹H NMR and ¹³C
NMR analysis methods.

Anahtar Kelimeler

pyrazole-3-carboxylic acid, pyrazole, ester, ureide, carboxamide

4-(ETOKSİKARBONİL)-1-(3-NİTROFENİL)-5-FENİL-1H-PİRAZOL-3-KARBOKSİLİK ASİDİN BAZI ESTER AMİT VE ÜREİD TÜREVLERİNİN SENTEZİ VE KARAKTERİZASYONU

Öz

Bu çalışmada bir
pirazol karboksilik asit türevi olan 4-(etoksikarbonil)-1-(3-nitrofenil)-5-fenil-1H-pirazol-3-karboksilik asit (1) bileşiğinin bazı yeni türevleri
sentezlendi. Bunun için, 1
bileşiğinin çeşitli alkollerle reaksiyonundan ester türevleri (3–6), amonyak ve üre ile reaksiyonundan
ise sırasıyla amit (7) ve üreid (8) türevleri elde edildi. Ayrıca 1 bileşiğinin dekarboksilasyonu ile de
yeni bir pirazol türevi (9)
sentezlendi. Sentezlenen bileşiklerin yapıları, FT-IR, ¹H NMR ve ¹³C NMR
spektroskopik yöntemleri kullanılarak aydınlatıldı.

Anahtar Kelimeler

pirazol-3-karboksilik asit, pirazol, ester, üreid, karboksamit

Kaynakça

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