Symmetric Multiple Basal Cell Carcinoma on the Face

Yıl 2009, Cilt: 11 Sayı: 2, 33 - 37, 01.07.2009

Nurten Turhan-haktanır Çiğdem Tokyol Abdullah Ayçiçek Yavuz Demir

Öz

The most important etiologic factor of basal cell carcinoma, which is the most frequent skin cancer, is ultraviolet-B exposure. Synchronous multiple tumors are exceptional and if present, they commonly associate a syndrome. In a 75 years-old man, ulcerated and crusted, macular and nodular lesions on face and scalp were excised and pathologic examination revealed basal cell carcinoma. No accompanying syndromic finding was found. Non-syndromic multiple basal cell carcinomas are rare in the literature. Since increasing effect of ultraviolet-B with aging may cause multiple tumors, the follow up of these patients are important

Anahtar Kelimeler

Multiple basal cell carcinoma, etiology, sun exposure

Yüzde simetrik yerleşimli multipl bazal hücreli karsinom

Öz

Bazal hücreli karsinom (BHK) en sık görülen cilt tümörü olup etyolojisindeki en önemli faktör ultraviyole-B (UV-B) maruziyetidir. Eş zamanlı multipl lezyonlar nadir olup görüldüklerinde genellikle bir sendroma eşlik ederler. 75 yaşında erkek hastada yüz ve saçlı deride, ülserasyon ve kabuklanmalar görülen, maküler ve nodüler lezyonlar eksize edildi ve patolojik incelemesi BHK olarak bildirildi. Eşlik eden herhangi bir sendromik bulguya rastlanmadı. Literatürde bir sendroma eşlik etmeyen multipl BHK olguları nadirdir. İlerleyen yaşla birlikte UV-B’nin artan etkisi birden fazla tümör oluşumuna yol açabileceği için bu hastaların takibi önemlidir

Anahtar Kelimeler

Multipl bazal hücreli karsinom, etyoloji, güneş maruziyeti

Kaynakça

• Walling HW, Fosko SW, Geraminejad PA, Whitaker DC, Arpey CJ: Aggressive basal cell carcinoma: Presentation, pathogenesis, and management. Cancer Metastasis Rev. 23:389- 402, 2004.
• Horlock NM, Wilson GD, Daley FM, Richman PI
• characteristics of basal cell carcinoma: relationship histopathology. Eur J Surg Oncol, 23:247-252, 1997.
• Olbricht SM: Cutaneous carcinomas. In: Georgiade GS, Riefkohl R, Scott Levin L (eds): Georgiade Reconstructive Surgery, 3rd ed. Baltimore: Williams & Wilkins. pp: 122-126, 1997.
• Betti K, Inselvini E, Carducci M, Crosti C: Age and site prevalence of histologic subtypes of basal cell carcinomas. Int J Dermatol 1995;34:174-176, 1995.
• Weihrauch M, Bader M, Lehnert G, Wittekind C, Tannapfel A, Wrbitzky R: Carcinogen- specific mutation pattern in the p53 tumour suppressor gene in UV radiation-induced basal cell carcinoma. Int Arch Occup Environ Health. 75:272-276, 2002.
• Leffel DJ, Fitzgeral DA: Basal cell carcinoma. In: Freadberg IM, Eisen AZ, Wolff K, Auston KF, Goldsmith LA, Katz SI, Fitzpatrick TB (eds): Fitzpatrick’s Dermatology in General Medicine. New York: McGraw Hill. Vol:1, pp: 857-864, 1999.
• Golitz LE, Norris DA, Luekens CA Jr, Charles DM: Nevoid basal cell carcinoma syndrome. Multiple basal cell carcinomas of the palms after radiation therapy. Arch Dermatol. 116:1159-63, 1980.
• Gailani MR, Ståhle-Bäckdahl M, Leffell DJ, Glynn M, Zaphiropoulos PG, Pressman C, Undén AB, Dean M, Brash DE, Bale AE, Toftgård R: The role of the human homologue of Drosophilia patched in sporadic basal cell carcinomas. Nat Gen 14:79-81, 1996.
• David Weedon: Tumors of the epidermis. Skin Pathology. Churchill Livingstone. pp: 765-771, 2002.
• Vabres P, Lacombe D, Rabinowitz LG, Aubert G, Anderson CE, Taieb A, Bonafé JL, Hors-Cayla MC: The gene for Bazex-Dupré- Christol syndrome maps to chromosome Xq. J Invest Dermatol. 105:87-91, 1995.
• van Steensel MA, Jaspers NG, Steijlen PM: A case of Rombo syndrome Br J Dermatol. 144:1215-1218, 2001.
• Brash DE, Ziegler A, Jonason AS, Simon JA, Kunala S, Leffell DS: Sunlight and sunburn in human skin cancer: p53, apoptosis, and tumor promotion. J Invest Dermatol Symp Proc 1: 136– 142, 1996.
• Hartevelt MM, Bavinck JN, Kootte AM, Vermeer BJ, Vandenbroucke JP: Incidence of skin cancer after renal transplantation in the Netherlands. Transplantation. 1990;49:506–509.
• Cohen C: Multiple cutaneous carcinomas and lymphomas of the skin. Arch Dermatol. 116:687–689, 1980.