Application of PCR and PLS Tools for the Simultaneous Quantification of Praziquantel and Ivermectin Binary Mixtures in Veterinary Tablets

Eda Büker; Erdal Dinç; Nagihan Yaşar

doi:10.29130/dubited.1051389

EN TR

Application of PCR and PLS Tools for the Simultaneous Quantification of Praziquantel and Ivermectin Binary Mixtures in Veterinary Tablets

Abstract

Two chemometric calibration methods, principal component regression (PCR) and partial least squares regression (PLS) were proposed for the simultaneous spectrophotometric determination of praziquantel (PRA) and ivermectin (IVE) in a marketed veterinary formulation without using preliminary separation step. UV spectra of calibration set and samples including PRA and IVE were recorded in the spectral region of 225-315 nm. PCR and PLS algorithms were applied to absorbance data matrix and concentration set including PRA and IVE in the linear concentration range of 20.0-160.0 µg/mL for PRA and 2.0-44.0 µg/mL for IVE. The capability of the PCR and PLS methods were validated by analyzing validation samples. Assay results showed that both PCR and PLS approaches provided an opportunity for quantifying PRA and IVE in veterinary tablet formulation.

Keywords

PCR and PLS calibrations, Simultaneous quantification, Praziquantel, Ivermectin, Veterinary tablet preparation

References

[1] A. Dayan, “Albendazole, mebendazole and praziquantel. Review of non‐clinical toxicity and pharmacokinetics,” Acta Tropica, vol. 86, pp. 141–159, 2003. https://doi.org/10.1016/S0001-706X(03)00031-7
[2] Eric A. Ottesen, and W. Campbell, “Ivermectin in human medicine,” Journal of Antimicrobial Chemotherapy, vol. 34, no. 2, pp. 195–203, 1994.
[3]. M. S. Piantavini, F. L. Pontes, L. X. Weiss, M. M. Senab, and R. Pontarolo, “Comparison between ultraviolet and infrared spectroscopies for the simultaneous multivariate determination of pyrantel and praziquantel,” J Braz Chem Soc., vol. 26, pp. 1387-95, 2015. doi:10.5935/0103-5053.20150107
[4] H. M. Phatak, V. V. Vaidya, M. S. Phatak, and D. Rajeghadge, “A rapid high performance liquid chromatography method for simultaneous quantification of praziquantel, ivermectin and abamectin from veterinary formulations: Development, validation and application,” Int J Pharm Res Scholars, vol. 5, pp. 57-65, 2016.
[5] S. Rupali, B. Shyamala, K. Kulesh, and K. J. Shailendra, “Simultaneous estimation of pyrantel pamoate, praziquantel & febantel by high performance liquid chromatography using dual wavelength,” J Appl Pharm Res., vol. 2, pp. 32-43, 2014.
[6] R. Rajesh, and J. J. Jithu, “A validated RP-HPLC method for simultaneous estimation of pyrantel pamoate and praziquantel in bulk and pharmaceutical dosage form,” Int J Pharm Pharm Sci, vol. 11, pp. 62-67, 2019. doi:10.22159/ijpps.2019v11i5.30488
[7] W. Hanpitakpong, V. Banmairuroi, B. Kamanikom, A. Choemung, and K. Na-Bangchang, “A high-performance liquid chromatographic method for determination of praziquantel in plasma,” Journal of Pharmaceutical and Biomedical Analysis, vol. 36 , pp. 871–876, 2004.
[8] G. Vijay Kumar, B. Sravanthi, and A. Praveen, “Analytical method development and validation for ivermectin and albendazole in combine dosage form by RP-HPLC,” Int J Curr Trends Pharma Res., vol. 7, pp. 7-12, 2019.
[9] B. Bhavya, P. Nagaraju, V. Mounika, and G. I. Priyadarshini, “Stability indicating RP-HPLC method development and validation for simultaneous estimation of albendazole and ivermectin in pharmaceutical dosage form,” Asian J Pharm Anal., vol. 7, pp. 6-14, 2017. doi:10.5958/2231-5675.2017.00002.3
[10] A.K. Patel, H.V. Joshi, and J.K. Patel, “Development and validation of stability indicating RP-HPLC method for estimation of ivermectin and albendazole in pharmaceutical dosage form,” Indian J. Drugs, vol. 3, pp. 57–70, 2015.

[11] L. K. Vegad, B. D. Paranjape, A. D. Shah, D. E. Patel, K. Y. Patel, and R. K. Patel, “Development and validation of RP-HPLC method for simultaneous estimation of ivermectin and clorsulon in ivercam injection,” Indo Am. J. Pharm. Res., vol. 7, pp. 523–531, 2017.
[12] M. Shurbaji, M. H. Abu Al Rub, M. M. Saket, A. M. Qaisi, M. L. Salim, and E. S. Abu-Nameh, “Development and validation of a new HPLC-UV method for the simultaneous determination of triclabendazole and ivermectin B1a in a pharmaceutical formulation,” J. AOAC Int., vol. 93, pp. 1868–1873, 2010.
[13] N. Salem Rasheda, S. Zayedb, A. Abdelazeema, and F. Fouada, “Development and validation of a green HPLC method for the analysis of clorsulon, albendazole, triclabendazole and ivermectin using monolithic column: Assessment of the greenness of the proposed method,” Microchemical Journal, vol. 157, no. 105069, pp. 1-10, 2020. https://doi.org/10.1016/j.microc.2020.105069
[14] E. Felici, C. Casado, C.C. Wang, J. Raba, and M.R. Gomez, “A green alternative method for analysis of ivermectin and moxidectin in environmental water samples using automatized preconcentration previous MEEKC,” Electrophoresis, vol. 37, pp. 2977–2985, 2016.
[15] N. V. Suresh Kumar Devaka, and V. Madhusudhan Rao, “Chromatographic Quantification of Ivermectin and Pranziquantel in the Tablets Using Stability Indicating RP-HPLC Method,” Pharmaceutical Sciences, vol. 25, pp. 254-261, 2019. doi: 10.15171/PS.2019.41
[16] A. Kulik, A. Szczotkowska, W. Bia£Ecka, M. Podolska, B. Kwiatkowska-Puchniarz and A. Mazurek, “Determination of Active Substances in Binary Mixture Antiparasitic Veterinary Formulations By Hplc,” Acta Poloniae Pharmaceutica in Drug Research, vol. 68, no. 4, pp. 467-472, 2011.
[17] F. L. Degaut Pontes, R. Pontarolo, F. R. Campos, J. C. Gasparetto, M. A. Cardoso, M. S. Piantavini, and A. C. Leal Badaró Trindade, “Development And Validation of An Hplc-Ms/Ms Method For Simultaneous Determination of Ivermectin, Febantel, Praziquantel, Pyrantel Pamoate And Related Compounds in Fixed Dose Combination for Veterinary Use,” Asian J Pharm Clin Res, vol. 6, no. 2, pp. 191-200, 2013.
[18] F. L. Pontes, R. O. Pontarolo, F. R. Campos, J. C. Gasparetto, M. A. Cardoso, M. S. Piantavini, et al., “Development and validation of an HPLC-MS/MS method for simultan ous determination of ivermectin, febantel, praziquantel, pyrantel pamoate and related compounds in fixed dose combination for veterinary use,” Asian J Pharm Clin Res.,” vol. 6,pp. 191-9, 2013.
[19] E. Dinç, A. Ozdemir, H. Aksoy, and Ö. Üstündağ, “Chemometric Determination of Naproxen Sodium and Pseudoephedrine Hydrochloride in Tablets by HPLC,” Chem. Pharm. Bull., vol. 54, pp. 415-421, 2006.
[20] E. Dinç, Ö. Üstündağ, and D.Baleanu, “Simultaneous chemometric determination of pyridoxine hydrochloride and isoniazid in tablets by multivariate regression methods,” Drug Testing and Analysis, vol. 2, pp. 383-387, 2010.
[21] E. Dinç, and D. Baleanu, “Chemometric Simultaneous Determination of Atorvastatin and Amlodipine in Tablets by PCR and PLS Calibrations,” Revista de Chimie -Bucharest- Original Edition, vol. 2, pp. 127-130, 2009.

Details

Primary Language

English

Subjects

Engineering

Journal Section

Research Article

Authors

Eda Büker ^*
0000-0002-9427-3119
Türkiye

Erdal Dinç
0000-0001-6326-1441
Türkiye

Nagihan Yaşar
0000-0002-1770-6013
Türkiye

Publication Date

January 31, 2022

Submission Date

December 30, 2021

Acceptance Date

January 13, 2022

Published in Issue

Year 2022 Volume: 10 Number: 1

DOI

https://doi.org/10.29130/dubited.1051389

IZ

https://izlik.org/JA67XZ29LZ

APA

Büker, E., Dinç, E., & Yaşar, N. (2022). Application of PCR and PLS Tools for the Simultaneous Quantification of Praziquantel and Ivermectin Binary Mixtures in Veterinary Tablets. Duzce University Journal of Science and Technology, 10(1), 385-397. https://doi.org/10.29130/dubited.1051389

AMA

1.Büker E, Dinç E, Yaşar N. Application of PCR and PLS Tools for the Simultaneous Quantification of Praziquantel and Ivermectin Binary Mixtures in Veterinary Tablets. DUBİTED. 2022;10(1):385-397. doi:10.29130/dubited.1051389

Chicago

Büker, Eda, Erdal Dinç, and Nagihan Yaşar. 2022. “Application of PCR and PLS Tools for the Simultaneous Quantification of Praziquantel and Ivermectin Binary Mixtures in Veterinary Tablets”. Duzce University Journal of Science and Technology 10 (1): 385-97. https://doi.org/10.29130/dubited.1051389.

EndNote

Büker E, Dinç E, Yaşar N (January 1, 2022) Application of PCR and PLS Tools for the Simultaneous Quantification of Praziquantel and Ivermectin Binary Mixtures in Veterinary Tablets. Duzce University Journal of Science and Technology 10 1 385–397.

IEEE

[1]E. Büker, E. Dinç, and N. Yaşar, “Application of PCR and PLS Tools for the Simultaneous Quantification of Praziquantel and Ivermectin Binary Mixtures in Veterinary Tablets”, DUBİTED, vol. 10, no. 1, pp. 385–397, Jan. 2022, doi: 10.29130/dubited.1051389.

ISNAD

Büker, Eda - Dinç, Erdal - Yaşar, Nagihan. “Application of PCR and PLS Tools for the Simultaneous Quantification of Praziquantel and Ivermectin Binary Mixtures in Veterinary Tablets”. Duzce University Journal of Science and Technology 10/1 (January 1, 2022): 385-397. https://doi.org/10.29130/dubited.1051389.

JAMA

1.Büker E, Dinç E, Yaşar N. Application of PCR and PLS Tools for the Simultaneous Quantification of Praziquantel and Ivermectin Binary Mixtures in Veterinary Tablets. DUBİTED. 2022;10:385–397.

MLA

Büker, Eda, et al. “Application of PCR and PLS Tools for the Simultaneous Quantification of Praziquantel and Ivermectin Binary Mixtures in Veterinary Tablets”. Duzce University Journal of Science and Technology, vol. 10, no. 1, Jan. 2022, pp. 385-97, doi:10.29130/dubited.1051389.

Vancouver

1.Eda Büker, Erdal Dinç, Nagihan Yaşar. Application of PCR and PLS Tools for the Simultaneous Quantification of Praziquantel and Ivermectin Binary Mixtures in Veterinary Tablets. DUBİTED. 2022 Jan. 1;10(1):385-97. doi:10.29130/dubited.1051389

Application of PCR and PLS Tools for the Simultaneous Quantification of Praziquantel and Ivermectin Binary Mixtures in Veterinary Tablets

Application of PCR and PLS Tools for the Simultaneous Quantification of Praziquantel and Ivermectin Binary Mixtures in Veterinary Tablets

Abstract

Keywords

Veteriner Tabletlerinde Prazikuantel ve İvermektinin Eş Zamanlı Ölçümü için PCR ve PLS Yöntemlerinin Uygulanması

Abstract

Keywords

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite