Yıl 2020, Cilt 8 , Sayı 1, Sayfalar 608 - 616 2020-01-31

Asimetrik Schiff Bazı Ni(II) Komplekslerinin Antimutajenik Aktivitesinin Değerlendirilmesi
Evulation of Antimutagenic Activity of Ni(II) Complexes with Unsymmetric Schiff Bases

Dilek NARTOP [1] , Elvan HASANOĞLU ÖZKAN [2] , Hamit Emre KIZIL [3] , Güleray AĞAR [4] , Nurşen SARI [5]


Bu çalışmada, asimetrik Ni(II) kompleksleri (NiL1, NiL2, NiL3, NiL4) potansiyel antimutajen özelliklerini incelemek için son zamanlarda grubumuzdan biri tarafından rapor edilen yeni iki aşamalı bir yöntem ile hazırlandı. Lenfositlerdeki sodyum azid kaynaklı antimutagenik etki, kardeş kromatid değişimi (SCE) ve mikronükleus (MN) yöntemleriyle belirlendi. Sentezlenen bileşiklerin antimutagenik özelliklere sahip olduğu ve pozitif kontrol olarak kullanılan sodyum azid (NaN3)'ün neden olduğu mutajeniteyi azalttıkları belirlenmiştir.

In this work, Ni(II) complexes with unsymmetric Schiff bases (NiL1, NiL2, NiL3, NiL4) were prepared by a two-stage method reported by one of us recently for investigate antimutagenic properties. Sodium azide-induced antimutagenic effect in lymphocytes was determined by sister chromatid exchange (SCE) and micronucleus (MN) methods. It has been determined that the synthesized compounds have antimutagenic properties and reduce the mutagenicity caused by sodium azide (NaN3) which is used as a positive control.

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Birincil Dil en
Konular Mühendislik
Bölüm Makaleler
Yazarlar

Orcid: 0000-0002-0705-5018
Yazar: Dilek NARTOP (Sorumlu Yazar)
Kurum: DUZCE UNIVERSITY
Ülke: Turkey


Orcid: 0000-0001-7338-4015
Yazar: Elvan HASANOĞLU ÖZKAN
Kurum: Gazı University
Ülke: Turkey


Orcid: 0000-0001-6193-3734
Yazar: Hamit Emre KIZIL
Kurum: BAYBURT UNIVERSITY
Ülke: Turkey


Orcid: 0000-0002-8445-5082
Yazar: Güleray AĞAR
Kurum: ATATURK UNIVERSITY
Ülke: Turkey


Orcid: 0000-0002-4764-7747
Yazar: Nurşen SARI
Kurum: Gazı University
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 31 Ocak 2020

Bibtex @araştırma makalesi { dubited575747, journal = {Düzce Üniversitesi Bilim ve Teknoloji Dergisi}, issn = {}, eissn = {2148-2446}, address = {}, publisher = {Düzce Üniversitesi}, year = {2020}, volume = {8}, pages = {608 - 616}, doi = {10.29130/dubited.575747}, title = {Evulation of Antimutagenic Activity of Ni(II) Complexes with Unsymmetric Schiff Bases}, key = {cite}, author = {NARTOP, Dilek and HASANOĞLU ÖZKAN, Elvan and KIZIL, Hamit Emre and AĞAR, Güleray and SARI, Nurşen} }
APA NARTOP, D , HASANOĞLU ÖZKAN, E , KIZIL, H , AĞAR, G , SARI, N . (2020). Evulation of Antimutagenic Activity of Ni(II) Complexes with Unsymmetric Schiff Bases. Düzce Üniversitesi Bilim ve Teknoloji Dergisi , 8 (1) , 608-616 . DOI: 10.29130/dubited.575747
MLA NARTOP, D , HASANOĞLU ÖZKAN, E , KIZIL, H , AĞAR, G , SARI, N . "Evulation of Antimutagenic Activity of Ni(II) Complexes with Unsymmetric Schiff Bases". Düzce Üniversitesi Bilim ve Teknoloji Dergisi 8 (2020 ): 608-616 <https://dergipark.org.tr/tr/pub/dubited/issue/49725/575747>
Chicago NARTOP, D , HASANOĞLU ÖZKAN, E , KIZIL, H , AĞAR, G , SARI, N . "Evulation of Antimutagenic Activity of Ni(II) Complexes with Unsymmetric Schiff Bases". Düzce Üniversitesi Bilim ve Teknoloji Dergisi 8 (2020 ): 608-616
RIS TY - JOUR T1 - Evulation of Antimutagenic Activity of Ni(II) Complexes with Unsymmetric Schiff Bases AU - Dilek NARTOP , Elvan HASANOĞLU ÖZKAN , Hamit Emre KIZIL , Güleray AĞAR , Nurşen SARI Y1 - 2020 PY - 2020 N1 - doi: 10.29130/dubited.575747 DO - 10.29130/dubited.575747 T2 - Düzce Üniversitesi Bilim ve Teknoloji Dergisi JF - Journal JO - JOR SP - 608 EP - 616 VL - 8 IS - 1 SN - -2148-2446 M3 - doi: 10.29130/dubited.575747 UR - https://doi.org/10.29130/dubited.575747 Y2 - 2019 ER -
EndNote %0 Düzce Üniversitesi Bilim ve Teknoloji Dergisi Evulation of Antimutagenic Activity of Ni(II) Complexes with Unsymmetric Schiff Bases %A Dilek NARTOP , Elvan HASANOĞLU ÖZKAN , Hamit Emre KIZIL , Güleray AĞAR , Nurşen SARI %T Evulation of Antimutagenic Activity of Ni(II) Complexes with Unsymmetric Schiff Bases %D 2020 %J Düzce Üniversitesi Bilim ve Teknoloji Dergisi %P -2148-2446 %V 8 %N 1 %R doi: 10.29130/dubited.575747 %U 10.29130/dubited.575747
ISNAD NARTOP, Dilek , HASANOĞLU ÖZKAN, Elvan , KIZIL, Hamit Emre , AĞAR, Güleray , SARI, Nurşen . "Evulation of Antimutagenic Activity of Ni(II) Complexes with Unsymmetric Schiff Bases". Düzce Üniversitesi Bilim ve Teknoloji Dergisi 8 / 1 (Ocak 2020): 608-616 . https://doi.org/10.29130/dubited.575747
AMA NARTOP D , HASANOĞLU ÖZKAN E , KIZIL H , AĞAR G , SARI N . Evulation of Antimutagenic Activity of Ni(II) Complexes with Unsymmetric Schiff Bases. DÜBİTED. 2020; 8(1): 608-616.
Vancouver NARTOP D , HASANOĞLU ÖZKAN E , KIZIL H , AĞAR G , SARI N . Evulation of Antimutagenic Activity of Ni(II) Complexes with Unsymmetric Schiff Bases. Düzce Üniversitesi Bilim ve Teknoloji Dergisi. 2020; 8(1): 616-608.