The Use and Importance of Procalcitonin as a Biomarker in Veterinary Clinical Practice

Abstract

Bir Akut Faz Protein Olan Prokalsitonin’in Biyobelirteç Olarak Veteriner Hekimlik Klinik Pratiğinde Kullanımı ve Önemi

Öz

Veteriner hekimlikte klinik şartlarında septisemi vakalarının erken saptanması ve prognozunun değerlendirilmesi veteriner hekimler için oldukça güçtür. Bu konuda seri kullanılan belirteçler yetersiz ve spesifik değildir. Bu nedenle son yıllarda glikoprotein yapıda, bir akut faz protein olan prokalsitoninin diagnostik etkilerine olan ilgi artmıştır. Prokalsitonin (PCT), kalsitonin (CT) hormonunun prekürsörü olan, primer olarak tiroid bezindeki C-hücrelerince ve küçük miktarlarda da akciğer ve bağırsak gibi organlardaki nöroendokrin dokularca sentezlenen, kalsiyum homeostazisinde düzenleyici olarak görev alan öncül bir proteindir. Genel manada inflamasyon, vücuda hasar veren bir uyaran ve bu söz konusu hasarın önüne geçmek adına; kapillar dilatasyon, lökosit infiltrasyonu, kızarıklık, ısı artışları, şişlik ve ağrıyla seyreden, hücresel hasara yol açan lokal yanıt olarak tanımlanmakta ve bu reaksiyon, zararlı ajanların ve hasarlı dokunun vücuttan uzaklaştırılmasını sağlayan mekanizmayı başlatmaktadır. Bu derlemede, hayvanlarda septisemi durumlarını saptamak, bu vakalarda prognozu yorumlamak, bakteriyel ve viral hastalıkları birbirinden ayırt etmek, uyguladığımız antibiyotiklerin etkilerini değerlendirmek ve veteriner hekimlik alanında yeni bir belirteç olarak kullanılabileceğine inandığımız prokalsitonin hakkında detaylı bilgi verilmesi amaçlanmıştır.

Anahtar Kelimeler

• Prokalsitonin
• sepsis
• veteriner hekimlik

Kaynakça

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