CANCER BIOCHEMISTRY

Abstract

In consequences of recent researches, new approaches had been presented for cancer and biochemical mechanisms explaning every steps of cancer from formation to maturation. Cancer is multistep and long term process at genotypical and phenotypical level. The formation and maturation of cancer are tried to explain in molecular level by biochemical mechanisms responsible from cell seperation and development molecules stimulating cell development, proteins controlling and arranging development genes and mechanisms responsible to limit development just in time.İn the future, the new and more special treatment methods are necessary instead of classical cancer treatments owing to new knowledgements obtained on the cell cycle and cancer field. 

Keywords

• Cancer,cancer biochemistry,protooncogenes,oncogenes,apopitozis,cell cycle,cell growth,tümör suppressor genes,DNA repair genes,cytokines,oncogenesis

Kanser Biyokimyası

Öz

Son yıllarda yapılan çalışmalar kanserin oluşumu ve gelişimi ile ilgili biyokimyasal ve moleküler düzeyde yeni katkılar sağlamıştır. Kanser çok basamaklı ve uzun süreli genotipik ve fenotipik düzeyde bir süreçtir. Günümüzde hücre bölünme ve büyümesinden sorumlu biyokimyasal mekanizmalar, hücre büyümesini uyaran moleküller, büyüme mekanizmasını kontrol eden proteinler, gerektiği zamanda büyümenin sınırlandırılmasından sorumlu olan genler ve mekanizmalar ile kanser oluşumu ve gelişimi, moleküler düzeyde açıklanmaya çalışılmaktadır. Önümüzdeki yıllarda, klasik kanser tedavileri yerine hücre siklusu ve kanser alanında elde edilen yeni bilgilerin ışığında, yeni ve daha özel tedavi yöntemleri uygulanacaktır. 

Anahtar Kelimeler

• kanser,kanser biyokimyası,protoonkogenler,onkogenler,apopitozis,hücre siklusu,hücre büyümesi,tümör baskılayıcı genler,DNA onarım genleri,sitokinler,onkogenez

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