Oxidative DNA Damage Products and Diseases

Öz

The free radicals formed with many ways and antioxidant defence mechanism is in a balance within the organism. In cases when
the free radicals are not cleaned enough from the organism, it causes damage to the DNA and damage products are formed. These
damage products can lead to many metabolic diseases, to aging, to cancer and even modifications in the structure of DNA which is a
genetic material. 8-hydroxy-2’-deoxyguanosine (8-OHdG) is a damage product whose mutagenity is most known.

Anahtar Kelimeler

• DNA,Diseases,Oxidative Damage,8-OHdG

Oksidatif DNA Hasar Ürünleri ve Hastalıklar

Öz

Organizmada, çeşitli yollarla oluşan serbest radikallerle antioksidan savunma sistemi denge halindedir. Bununla beraber serbest
radikallerin organizmadan yeterince temizlenemediği durumlarda DNA’da hasara yol açmakta ve hasar ürünleri şekillenmektedir.
Bu hasar ürünleri çeşitli metabolik hastalıklara, yaşlanmaya, kansere ve hatta genetik materyal olan DNA yapısındaki
modifikasyonlara neden olabilmektedir. Mutajenitesi en çok bilinmekte olan hasar ürünlerinden bir tanesi de 8-hidroksi-2’-
deoksiguanozin (8-OHdG)’dir.

Anahtar Kelimeler

• DNA,Hastalıklar,Oksidatif Hasar,8-OHdG

Kaynakça

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