Kadmiyum ile Oluşturulan Deneysel Karaciğer Hasarına Karşı Bal ve Polenin Lipid Peroksidayon ve Bazı Antioksidanlar Üzerine Etkisi

Öz

Bu çalışmada kadmiyum (Cd) verilen ratlarda karaciğer dokusunda; glutatyon peroksidaz (GSH-Px), katalaz (KAT), glutatyon (GSH) ve malondialdehit (MDA) düzeylerine bal ve polen verilmesi ile oluşacak değişikliklerin belirlenmesi amaçlanmıştır. Çalışma ratlar üzerinde yapıldı ve 5 grup oluşturulmuştur. 1. Grup Kontrol, 2. Grup Cd, 3. Grup Cd+bal, 4. Grup Cd+polen, 5. Grup Cd+bal+polen şeklinde düzenlenmiştir. Uygulama 6 hafta sürmüştür. Uygulama sonrası doku GSH-Px, KAT, GSH ve MDA düzeyleri ölçülmüştür. Yapılan istatistiksel değerlendirmede kontrol grubunda, Cd grubuna kıyasla, doku GSH-Px, KAT ve MDA düzeyleri önemli bulunurken, GSH düzeyinin ise önemsiz olduğu bulunmuştur. GSH-Px ve KAT aktivitesi; Cd grubu ile Cd+bal, Cd+polen ve Cd+bal+polen gruplarında önemli bulunmuş. MDA düzeyi; Cd grubu ile Cd+bal, Cd+polen ve Cd+bal+polen gruplarında önemli bulunurken, GSH düzeyinin ise tüm gruplarda önemsiz olduğu gözlenmiştir

Anahtar Kelimeler

• Antioksidan,Kadmiyum,Bal,Lipit Peroksidasyon,Polen,Rat

he Effect of Honey and Pollen on Lipid Peroxidation and Some Antioxidants Against Experimental Liver Damage With Cadmium

Abstract

The aim of this study was to determine the changes in cadmium (Cd) expose rats in liver tissue by giving honey and pollen to glutathione peroxidase (GSH-Px), catalase (CAT), glutathione (GSH) and malondialdehyde (MDA).  The study was performed on rats and five groups were formed. The groups were designed as following; Group 1: Control, Group 2: Cd administered, Group 3: Cd+honey, Group 4: Cd+pollen, Group 5: Cd+honey+pollen. The application was lasted for six weeks. At the and of the study, tissue samples were collected and the levels of GSH-Px, CAT, GSH and MDA were measured. After statistical analyses, while the differences of amount of tissue GSH-Px, CAT and MDA levels between control and Cd groups were statistically important, the GSH levels were not. Activities of GSH-Px and CAT were important in Cd+honey, Cd+pollen and Cd+honey+pollen groups along with Cd, group. While the level of MDA were important in Cd and Cd+honey, Cd and Cd+pollen, Cd and Cd+honey+pollen, level of GSH in was found unimportant in all groups.

Keywords

• Antioxidant,Cadmium,Honey,Lipid Peroxidation,Pollen,Rat

Kaynakça

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