Zehirlenmelerde İntravenöz Lipit Emülsiyonu Tedavisi

Emre Bahçivan; Halis Oğuz

Zehirlenmelerde İntravenöz Lipit Emülsiyonu Tedavisi

Öz

İntravenöz lipit emülsiyon (ILE) tedavisi, dolaşımdaki zehirli maddelerin biyoyararlanım ve toksisitesini azaltmak için lipit emülsiyonlarının intravenöz infüzyon yoluyla kullanılmasını tanımlar. Lipit emülsiyonu yağ, emülsifier, tonisite değiştirici madde ve sudan oluşurken ve bileşiminde yaklaşık %80 su, %20 soya fasulyesi yağı, %2 gliserin ve %1 yumurta sarısı fosfolipidi bulunmaktadır. ILE’nin üretilme amacı öncelikli olarak yetişkinler, çocuklar ve yeni doğanlar için parenteral beslemedir. Bunun dışında ILE propofol ve amfoterisin B’de olduğu gibi ilaç taşıyıcısı olarak da kullanılmaktadır. ILE, lipofilik toksinleri absorbe etme yeteneklerine bağlı olarak veteriner hekimlikte ve insan hekimliğinde lokal anesteziklerin sistemik toksisitesinin tedavisinde de antidot olarak kullanılabilmektedir. Lipofilik ilaçlarla zehirlenmelerin tedavisinde belirgin klinik düzelme, uygulamasının nispeten kolay olması, düşük maliyet, söz konusu lipit emülsiyonlarının etiket dışı kullanımının artmasına neden olmuş ve zehirlenmelerin tedavisinde kullanılabilmesinin yolunu açmıştır. Bu makalede ILE’nin etki mekanizmaları, endikasyonları, mevcut ticari formülasyonları, dozaj rejimi önerisi ile yan etkileri hakkında bilgi verilmesi amaçlanmaktadır.

Anahtar Kelimeler

İntravenöz lipid emülsiyonu,lipofilik ilaçlar,zehirlenme

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

Derleme

Yazarlar

Emre Bahçivan ^* Bu kişi benim

Halis Oğuz

Yayımlanma Tarihi

30 Haziran 2019

Gönderilme Tarihi

12 Kasım 2018

Kabul Tarihi

24 Ocak 2019

Yayımlandığı Sayı

Yıl 2019 Cilt: 12 Sayı: 1

IZ

https://izlik.org/JA64MA78SB

Kaynak Göster

RIS / Bibtex

APA

Bahçivan, E., & Oğuz, H. (2019). Zehirlenmelerde İntravenöz Lipit Emülsiyonu Tedavisi. Dicle Üniversitesi Veteriner Fakültesi Dergisi, 12(1), 70-77. https://izlik.org/JA64MA78SB

AMA

1.Bahçivan E, Oğuz H. Zehirlenmelerde İntravenöz Lipit Emülsiyonu Tedavisi. Dicle Üniv Vet Fak Derg. 2019;12(1):70-77. https://izlik.org/JA64MA78SB

Chicago

Bahçivan, Emre, ve Halis Oğuz. 2019. “Zehirlenmelerde İntravenöz Lipit Emülsiyonu Tedavisi”. Dicle Üniversitesi Veteriner Fakültesi Dergisi 12 (1): 70-77. https://izlik.org/JA64MA78SB.

EndNote

Bahçivan E, Oğuz H (01 Haziran 2019) Zehirlenmelerde İntravenöz Lipit Emülsiyonu Tedavisi. Dicle Üniversitesi Veteriner Fakültesi Dergisi 12 1 70–77.

IEEE

[1]E. Bahçivan ve H. Oğuz, “Zehirlenmelerde İntravenöz Lipit Emülsiyonu Tedavisi”, Dicle Üniv Vet Fak Derg, c. 12, sy 1, ss. 70–77, Haz. 2019, [çevrimiçi]. Erişim adresi: https://izlik.org/JA64MA78SB

ISNAD

Bahçivan, Emre - Oğuz, Halis. “Zehirlenmelerde İntravenöz Lipit Emülsiyonu Tedavisi”. Dicle Üniversitesi Veteriner Fakültesi Dergisi 12/1 (01 Haziran 2019): 70-77. https://izlik.org/JA64MA78SB.

JAMA

1.Bahçivan E, Oğuz H. Zehirlenmelerde İntravenöz Lipit Emülsiyonu Tedavisi. Dicle Üniv Vet Fak Derg. 2019;12:70–77.

MLA

Bahçivan, Emre, ve Halis Oğuz. “Zehirlenmelerde İntravenöz Lipit Emülsiyonu Tedavisi”. Dicle Üniversitesi Veteriner Fakültesi Dergisi, c. 12, sy 1, Haziran 2019, ss. 70-77, https://izlik.org/JA64MA78SB.

Vancouver

1.Emre Bahçivan, Halis Oğuz. Zehirlenmelerde İntravenöz Lipit Emülsiyonu Tedavisi. Dicle Üniv Vet Fak Derg [Internet]. 01 Haziran 2019;12(1):70-7. Erişim adresi: https://izlik.org/JA64MA78SB