Sol Ventriküler Miyokardiyal Performans İndeksinin (Tei indeksi) Term ve Prematüre Yenidoğan Buzağılarda Karşılaştırılması

Öz

Yenidoğan kalbi, hem biyokimyasal hem de yapısal özellikler açısından yetişkin kalbinden farklıdır. İnsan neonatolojisindeki ekokardiyografik çalışmalar, prematüre bebeklerin sol ventrikülünün (LV) miyokardiyal fonksiyonunun zamanında doğan bebeklerden farklı olduğunu göstermektedir. Şimdiye kadar neonatal hayvanlarda miyokardiyal performans indeksini (MPI) içeren hiçbir çalışmaya rastlanılmamıştır. Bu çalışmanın amacı prematüre buzağılarda LV MPI'yi değerlendirmek ve sağlıklı yeni doğmuş buzağılarla karşılaştırmaktır. Gününde doğmuş 10 sağlıklı buzağı ve 20 prematüre buzağı çalışmaya dahil edildi. Ekokardiyografik değerlendirmeler doğumdan sonraki 1, 2 ve 3. günlerde yapıldı ve izovolümik kontraksiyon zamanı (IVCT), izovolümik relaksasyon süresi (IVRT), ejeksiyon zamanı (ET) ve MPI PW doku Doppler görüntüleme (PW-TDI) ile değerlendirildi. Çalışmanın sonuçları, prematüre buzağıların LV IVRT'sinin sağlıklı term buzağılara göre daha kısa olduğunu gösterdi. Sağlıklı gününde doğmuş buzağıların LVMPI değeri prematüre buzağılara göre daha yüksekti. Sonuç olarak, MPI ölçümü neonatal buzağılarda uygulanabilir bir yöntemdir. Prematüre buzağıların MPI'sindeki önemli düşüşler ve daha kısa IVRT, duktus arteriyozusun (DA) kapanmamasının ve azalmış afterload'un bir sonucu olarak ortaya çıkabilmektedir. Ekokardiyografi ve Doppler görüntüleme tekniği, neonatal buzağılarda kardiyovasküler sistemi incelemek ve izlemek için yararlı araçlar olduğu ortaya konulmuştur.

Anahtar Kelimeler

• Doppler
• Ekokardiyografi
• Miyokard performans indeksi
• Prematüre

The Comparison of Left Ventricular Myocardial Performance Index (Tei index) in Term and Prema-ture Neonatal Calves

Abstract

The neonatal heart is different from the adult heart in regard to both biochemical and structural features. Echocardiographic studies in human neonatology show that the myocardial function of left ventricle (LV) of premature infants differs from term infants. No study involving myocardial performance index (MPI) in neonatal animals has been performed until now. The objective of the present study was to evaluate LV MPI in premature calves and compare it to healthy newborn term calves. Ten healthy term and 20 premature calves were used. Echocardiographic evaluations were performed at days 1, 2, and 3 after birth and isovolumic contraction time (IVCT), isovolumic relaxation time (IVRT), ejection time (ET), and MPI calculated with PW tissue Doppler imaging (PW-TDI). Results of the study showed that the IVRT of the LV of premature calves was shorter than seen in healthy term calves. The LVMPI of healthy term calves was also higher than in premature calves. In conclusion, MPI measurement is feasible in neonatal calves. Significant decrements in MPI and shorter IVRT of preterm calves could be the result of the non-closure of the ductus arteriosus (DA), and along with the decreased afterload. Echocardiography and Doppler imaging technique are useful tools for exploring and follow up the cardiovascular system in neonatal calves.

Keywords

• Doppler
• echocardiography
• myocardial performance index
• premature

Kaynakça

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