Paraneoplastic Syndrome in Dogs

Yıl 2013, Sayı: 1, 19 - 24, 01.01.2013

İdil Baştan

Öz

Paraneoplastic disorders are indirect and usually remote effects that are caused by tumor cell products rather than by the primary
tumor or its metastases. For this reason recognition of paraneoplastic syndrome is important for early tumor diagnosis, treatment of
metabolic abnormalities and management. Paraneoplastic syndromes are a group of noncancerous disease associated with internal
neoplasia. Paraneoplastic conditions result from production and release of substances (hormone, cytokines, peptides, growth factors)
that are not normally produced by the cell of origin of the tumor. Paraneoplastic syndrome commonly presents as dermatological
manifestations but can also be evident as cardiac abnormalities, neuromuscular changes, ocular changes, hematological changes as
well as general clinical signs of weight loss, poliuria, polydipsia, diarrhea and anorexia. A number of diseases can be result in
paraneoplastic syndrome, including: hypercalcemia, disseminated intravascular coagulation, weight loss, enteropathi,
gastroduodenal ulcer, hypoglisemi, hyperrgastrinemia and hyperhistanemia, hyperviscosity, anemia, eosinophilia, leucocytosis,
neurological syndrome, hypertrophic osteoartropathy and cuteneous syndrome.

Anahtar Kelimeler

Paraneoplastic syndrome, dog

Köpeklerde Paraneoplastik Sendrom

Öz

Paraneoplastik bozukluklar primer tümör ve metastazlarından daha çok tümör hücrelerinin uzak dokularda neden olduğu
değişikliklerdir. Bu nedenle paraneoplastik sendrom tümörün erken tanısı, tedavisi ve metabolik değişikliklerin yönetimi açısından
önemlidir. Paraneoplastik sendrom tümörle ilgili kansorejen olmayan hastalık gruplarına verilen isimdir. Paraneoplastik durum
tümör orijinli hücreler hücreler tarafından normalde üretilmeyen bazı ürün ve maddelerle (hormon, sitokinler, peptidler, büyüme
faktörleri gibi) ilişkilidir. Köpeklerde paraneoplastik sendrom genellikle dermatolojik semptomlarla karakterizedir, fakat aynı
zamanda kalp anormallikleri, nörümüsküler, göz ile hematolojik değişiklikler ve de kilo kaybı, poliüri, polidipsi, ishal ve iştahsızlık
ta görülen değişikliklerdendir. En yaygın paraneoplastik sendrom: hiperkalsemi, dissemine intravasküler koagülasyon, kilo kaybı,
enteropati, gastroduodenal ülser, hipoglisemi, hipergastrinemi ve hiperhistanemi, hipervizkosite, anemi, eritrositozis, lökositozis,
trombositopeni, nörolojik sendrom, iskelet sistemine bağlı problemler ve kutenöz sendromdur.

Anahtar Kelimeler

Paraneoplastik sendrom, köpek

Kaynakça

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• 12. Paraneoplastic syndromes. Erişim: http://www.laboklin.de/pdf/en/lab_0802_p araneoplastic_syndromes.pdf Erişim tarihi: 14.01.2013