CANCER BIOCHEMISTRY

Yıl 2012, Sayı: 1, 7 - 18, 01.01.2012

Beran Yokuş Dilek Ülker Çakır

Öz

In consequences of recent researches, new approaches had been presented for cancer and
biochemical mechanisms explaning every steps of cancer from formation to maturation. Cancer is
multistep and long term process at genotypical and phenotypical level.
The formation and maturation of cancer are tried to explain in molecular level by biochemical
mechanisms responsible from cell seperation and development molecules stimulating cell development,
proteins controlling and arranging development genes and mechanisms responsible to limit development
just in time.İn the future, the new and more special treatment methods are necessary instead of classical
cancer treatments owing to new knowledgements obtained on the cell cycle and cancer field. 

Anahtar Kelimeler

Cancer, cancer biochemistry, protooncogenes, oncogenes, apopitozis, cell cycle, cell growth, tümör suppressor genes, DNA repair genes, cytokines, oncogenesis

Kanser Biyokimyası

Öz

Son yıllarda yapılan çalışmalar kanserin oluşumu ve gelişimi ile ilgili biyokimyasal ve moleküler düzeyde
yeni katkılar sağlamıştır. Kanser çok basamaklı ve uzun süreli genotipik ve fenotipik düzeyde bir süreçtir.
Günümüzde hücre bölünme ve büyümesinden sorumlu biyokimyasal mekanizmalar, hücre büyümesini
uyaran moleküller, büyüme mekanizmasını kontrol eden proteinler, gerektiği zamanda büyümenin
sınırlandırılmasından sorumlu olan genler ve mekanizmalar ile kanser oluşumu ve gelişimi, moleküler
düzeyde açıklanmaya çalışılmaktadır. Önümüzdeki yıllarda, klasik kanser tedavileri yerine hücre siklusu
ve kanser alanında elde edilen yeni bilgilerin ışığında, yeni ve daha özel tedavi yöntemleri
uygulanacaktır. 

Anahtar Kelimeler

kanser, kanser biyokimyası, protoonkogenler, onkogenler, apopitozis, hücre siklusu, hücre büyümesi, tümör baskılayıcı genler, DNA onarım genleri, sitokinler, onkogenez

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