Veteriner Destek Tedavi: Tarantula Cubensis Alkolik Ekstraktı, İnaktif Parapoxvirüs Ovis ve Corynebacterium Cutis Lizatı

Yıl 2017, Cilt: 10 Sayı: 1, 30 - 37, 19.02.2017

Devran Coşkun

Öz

Veteriner sahada
da beşeri hekimlikte olduğu gibi radikal tedaviye ilaveten destek tedaviler
kullanılmaktadır. Yapılan bu tedaviler arasında da en fazla Tarantula cubensis
alkolik ekstraktı, inaktif Parapoxvirüs ovis ve Corynebacterium cutis lizatı
kullanılmaktadır. Tarantula cubensis alkolik ekstraktı homeopatik ajan olarak
kullanılırken, inaktif Parapoxvirüs ovis ve Corynebacterium cutis lizatı ise
immunstimulan olarak kullanılmaktadır. Bu derlemede ticari olarak satışa
sunulan Tarantula cubensis alkolik ekstraktı, inaktif Parapoxvirüs ovis virüsü
ve Corynebacterium cutis lizatı içeren ürünlerin veteriner sahada kullanımı
hakkında bilgi verilmiştir.

Anahtar Kelimeler

Destek tedavi, veteriner klinik

Kaynakça

• 1. Anonim A. (2016). http://interhas.com.tr/arsivler/urunler/theranekron-d6#toggle-id-2, Erişim tarihi:07/11/2016.
• 2. Anonim B. (2016). http://www.gkgm.gov.tr/vtu/EMDetay.aspx?ID=1222, Erişim tarihi:07.11.16.
• 3. Anonim C. (2016). Zylexis, http://www.selfarma.com.tr/?p=3211, Erişim tarihi:21/11/2016.
• 4. Kaçar C, Kaya S. (2014). Uterine Infections in Cows and Effect on Reproductive Performance. Kafkas Universitesi Veteriner Fakültesi Dergisi. 20 (6): 975-982.
• 5. Hamali H, Fatehi H, Asadpour R. (2015). Effect of Theranekron on The Cows With Retained Fetal Membranes. Indian Journal of Natural Sciences. (6): 9521-9525.
• 6. Albay M.K, Şahinduran Ş, Kale M, Karakurum M.Ç, Sezer K. (2010). Influence of Tarantula Cubensis Extract on The Treatment of The Oral Lesions in Cattle With Bluetongue Disease. . Kafkas Universitesi Veteriner Fakültesi Dergisi. 16 (4): 593-596.
• 7. Gürbulak K, Akçay A, Gümüşsoy K.S. et al. (2014). Investigation of The Efficacy of Tarantula Cubensis Extract (Theranekron D6) in The Treatment of Subclinical and Clinical Mastitis in Dairy Cows, Turkish Journal Veterinary Animal Sciences. (38): 712-718.
• 8. Lotfollahzadeh S, Alizadeh M.R, Mohri M, Mokhber Dezfouli M.R. (2012). The therapeutic Effect of Tarentula Cubensis Extract (Theranekron(R)) in Foot-and-Mouth Disease in Cattle: A Randomised Trial in an Endemic Setting., Homeopathy, 101, 159-164.
• 9. Duz E, Icen H, Arserim N.B. et al. (2012). Comparison of Classic, Theranekron and Classic-Plus Theranekron Treatment on the Foot and Mouth Disease Lesions in Cattle in Van, Diyarbakir and Ankara Regions in Turkey. Journal of Animal and Veterinary Advances. (11): 3258-3261.
• 10. Paksoy Z, Gülesci N, Kandemir F.M, Dinçel G.C. (2015). Effectiveness of Levamisole and Tarantula Cubensis Extract in The Treatment of Teat Papillomatosis of Cows, Indian Journal of Animal Research. 49 (5) : 704-708.
• 11. Cam Y, Kibar M, Atasever A, Atalay Ö, Beyaz L. (2007). Efficacy of Levamisole and Tarantula Cubensis Venom For the Treatment of Bovine Cutaneous Papillomatosis, Veterinary Record. 160, 486-488.
• 12. Corum O, Er A, Dik B. (2016). Investigation of The Effect of Tarantula Cubensis Extract on Acute Phase Response, Acta Scientiae Veterinariae. (44): 1414.
• 13. Dik B, Er A, Corum O. (2014). Koyunlarda Tarantula Cubensis Alkolik Ekstraktının (Theranekron®) Serum Tiyobarbitürik Asit Reaktif Ürünlerine Etkisi, Eurasian Journal of Veterinary Sciences. 30 (2): 68-71.
• 14. Gonul R, Koenhemsi L, Aydin H. et al. (2015). Tarantula Cubensis Ekstraktının Koyunlardaki Elektrokardiyografik Durum ve İz Elementler Üzerindeki Etkileri, İstanbul Üniversitesi Veteriner Fakültesi Dergisi. 41 (1), 79-83.
• 15. Sardari K, Mohri M, Sabzevari S, Fathi B. (2014). Effects of the Theranekron® an Alcoholic Extract of The Tarantula Cubensis” on Hematology and Serum Biochemical Properties in Horses. Iranian Journal of Veterinary Science and Technology. 3(2): 9-16.
• 16. Gultiken N, Guvenc T, Kaya D. et al. (2015). Tarantula Cubensis Extract Alters The Degree of Apoptosis and Mitosis in Canine Mammary Adenocarcinomas. Journal of Veterinary Science. 16(2): 213-219.
• 17. Gültekin Ç, Koç B. (2015). Geniş Torakolumbal Yaranın Punch Greft Uygulaması ile Sağaltımı. Erciyes Universitesi Veteriner Fakültesi Dergisi. 12(2): 141-146.
• 18. Yardımcı C, Yardimci B. (2008). Indolent Ulcer in a Cat. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 55, 65-67.
• 19. Taşkaya Ş, Demirkan İ, Demirkan A.C, Korkmaz M. (2013). Kedi Gingivitis Sağaltımında Amoksisilin–Klavulanik Asit Ve Sulfadimetilprimidin–Trimetoprim Ajanlarının Klinik Etkilerinin Karşılaştırılması. Atatürk Üniversitesi Veteriner Bilimler Dergisi. 8(3): 216-223.
• 20. Oryan A, Moshiri A, Raayat A.R. (2012). Novel application of Theranekron(R) Enhanced The Structural and Functional Performance of The Tenotomized Tendon in Rabbits. Cells Tissues Organs. 196(5): 442-455.
• 21. Küçükaslan I, Oztürk O, Ünver O. (2013) An Uncommon Case in The Domestic Rabbit (Oryctolagus cuniculus): Mammary Neoplasm, Reproductive Biology. 13 (1): 52.
• 22. Dolapcioglu K, Dogruer G, Ozsoy S. et al. (2013). Theranekron for Treatment of Endometriosis in A Rat Model Compared With Medroxyprogesterone Acetate and Leuprolide Acetate. European Journal of Obstetrics & Gynecology and Reproductive Biology. 170(1): 206-210.
• 23. Adib-Hashemi F, Farahmand F, Hesari S.F. et al. (2015). Anti-inflammatory and Protective Investigations on The Effects of Theranekron(R) "an Alcoholic Extract of The Tarantula Cubensis" on Wound Healing of Peritoneal in The Rat: an In Vivo Comparative Study. Diagnostic Pathology. 10(1): 19.
• 24. Karabacak M, Eraslan G, Kanbur M, Sarica Z.S. (2015). Effects of Tarantula cubensis D6 on Aflatoxin-induced Injury in Biochemical Parameters in Rats. Homeopathy. 104(3): 205-210.
• 25. Anomin D. (2016). Zylexis. http://www.gkgm.gov.tr/vtu/EMDetay.aspx?ID=1247. Erişim tarihi:21.11.2016.
• 26. Strube W, Kretzdorn D, Grunmach J, Bergle R, Thein P. (1988). The Effectiveness of The Paramunity Inducer Baypamun (PIND-ORF) for The Prevention and Metaphylaxis of an Experimental Infection With The İnfectious Bovine Rhinotracheitis Virus in Cattle. Tierarztl. Prax. 17(3): 267-272.
• 27. Castrucci G, Frigeri F, Osburn B. et al. (1998). Further Investigations on The Efficacy of a Non-specific Defence İnducer Evaluated in Calves Exposed to Infectious Bovine Rhinotracheitis Virus. Comp. Immunol. Microbiol. Infect. Dis., 21(2): 155-163.
• 28. Metzner M, Behrmann K, Klee W. (1999). Efficacy of an İmmune Modulator in Enzootic Pneumonia of Dairy Calves. Journal of Veterinary Medicine Series A. 46(5): 293-299.
• 29. Zecconi A, Bronzo V, Casula A. et al. (1999). Efficacy of a Biological Response Modifier in Preventing Staphylococcus Aureus Intramammary Infections After Calving. Journal of Dairy Science. 82(10): 2101-2107.
• 30. Senturk S, Catik S, Temizel E, Ozyigit O. (2016). Outbreak of Bovine Papular Stomatitis With Concurrent Cryptosporidiosis in a Dairy Herd in Turkey. Bulgarian Journal of Veterinary Medicine. 19(1): 78-83.
• 31. Horohov D, Breathnach C, Sturgill T. et al. (2008). In vitro and In vivo Modulation of The Equine Immune Response by Parapoxvirus Ovis. Equine Veterinary Journal. 40(5): 468-472.
• 32. Ons E, Van Brussel L, Lane S. et al. (2014). Efficacy of a Parapoxvirus Ovis-based Immunomodulator Against Equine Herpesvirus Type 1 and Streptococcus Equi Equi Infections in Horses. Veterinary Microbiology. 173(3): 232-240.
• 33. Studer U, Marti E, Stornetta D, Lazary S, Gerber H. (1996). The Therapy of Equine Sarcoid With a Non-specific Immunostimulator--the Epidemiology and Spontaneous Regression of Sarcoids. Schweiz Arch Tierheilkd. 139(9): 385-391.
• 34. Lindner A, Von Wittke P, Thein P, Strube W. (1993). Effect of a Paramunity Inducer on The İncidence of Diseases and The Plasma Cortisol Content in Thoroughbred Foals Before and After Weaning. Tierarztl Prax. 21(1): 47-50.
• 35. Ziebell K.L, Steinmann H, Kretzdorn D. et al. (1997). The Use of Baypamun N in Crowding Associated Infectious Respiratory Disease: Efficacy of Baypamun N (Freeze Dried Product) in 4–10 Month Old Horses. Journal of Veterinary Medicine Series B. 44(1‐10): 529-536 .
• 36. Dreismann G.M. (2010). Effects of The Homeopathic Preparation Engystol® ad us. vet. on Stress Induced Parameters in Weaning Foals. Tierarztl Umsch. 65(12): 484-490.
• 37. Adams A.A, Horohov D.W. (2013). The Effect of an Immunomodulator (parapoxvirus ovis) on Cell-Mediated Immunity (CMI) in Abruptly Weaned Foals. Veterinary Immunology and Immunopathology. 153(1): 118-122.
• 38. Ryan C, Giguère S, Fultz L, Long M.T, Crawford P.C. (2010). Effects of Two Commercially Available Immunostimulants on Leukocyte Function of Foals Following Ex vivo Exposure to Rhodococcus equi. Veterinary Immunology and Immunopathology. 138(3), 198-205.
• 39. Schütze N, Raue R, Büttner M, Alber G. (2009). Inactivated Parapoxvirus Ovis Activates Canine Blood Phagocytes and T Lymphocytes. Veterinary Microbiology. 137 (3): 260-267.
• 40. Proksch A, Unterer S, Truyen U, Hartmann K. (2014). Efficacy of The Paramunity Inducer PIND-ORF in The Treatment of Canine Parvovirus Infection.The Veterinary Journal. 202 (2): 340-347.
• 41. Pekmezci D, Pekmezci G, Guzel M. et al. (2014). Efficacy of Amitraz Plus Inactivated Parapoxvirus Ovis in The Treatment of Canine Generalised Demodicosis. Veterinary Record. 174 (22): 556.
• 42. Hartmann K, Block A, Ferk G. et al. (1998). Treatment of Feline Leukemia Virus-Infected Cats With Paramunity Inducer. Veterinary Immunology and Immunopathology. 65 (2): 267-275.
• 43. Traeder W, Brune A, Rehagen M. (2005). Protective Effect of The Paramunity Inducer Parapoxvirus Ovis (Zylexis®) in Kittens Experimentally Infected With Calicivirus (Strain FCV-KS 20). Praktischer Tierarzt Hannover. 1 (4): 230-239.
• 44. Winer J.N, Arzi B, Verstraete F.J. (2016). Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of The Literature. Front. Journal of Veterinary Science. 3: 54.
• 45. Pavan T.R, Nied C.O, Noro M. et al. (2016). Inactivated Parapoxvirus Ovis as Inducer of Immunity in Silver Catfish (Rhamdia quelen). Anais da Academia Brasileira de Ciencias. 88 (3): 1451-1457.
• 46. Ortega C, Ruiz I, De Blas I. et al. (1996). Furunculosis Control Using a Paraimmunization Stimulant (Baypamun) in Rainbow Trout. Veterinary Research. 27 (6): 561-568.
• 47. Kyriakis S, Alexopoulos C, Giannakopoulos K. et al. (1996). Effect of A Paramunity Inducer on Reproductive Performance of Gilts. Journal of Veterinary Medicine Series A. 43 (1-10): 483-487.
• 48. Kyriakis S, Tzika E, Lyras D. et al. (1998).Effect of an Inactivated Parapoxvirus Based Immunomodulator (Baypamun) on Post Weaning Diarrhoea Syndrome and Wasting Pig Syndrome of Piglets. Research in Veterinary Science. 64 (3): 187-190.
• 49 Anziliero D, Weiblen R, Kreutz L, Spilki F, Flores E. (2014). Inactivated Parapoxvirus Ovis Induces a Transient Increase in The Expression of Proinflammatory, Th1-related, and Autoregulatory Cytokines in Mice. Brazilian Journal of Medical and Biological Research. 47 (2): 110-118.
• 50. Avci O, Bulut O, Dik I. (2016). Effects of Inactive Parapoxvirus Ovis on Cytokine Levels in Rats. The Journal of Veterinary Medical Science. 78 (1): 129-131.
• 51. Nowatzky J, Knorr A,Hirth-Dietrich C. et al. (2013). Inactivated Orf virus (Parapoxvirus ovis) Elicits Antifibrotic Activity in Models of Liver Fibrosis. Hepatology Research. 43 (5): 535-546.
• 52. Fiebig H.H, Siegling A, Volk H.D. et al. (2011). Inactivated Orf Virus (Parapoxvirus ovis) Induces Antitumoral Activity in Transplantable Tumor Models. Anticancer Research. 31 (12): 4185-4190.
• 53. Anonim E. (2017). Ruhsatlı Veteriner Tıbbı Ürünler http://www. gkgm. gov. tr/vtu/EMDetay.aspx?ID=911. Erişim Tarihi: 11.01.2017.
• 54. Anonim F. (2017). Ultra-corn. http://www.selfarma.com.tr/? p=995. Erişim Tarihi: 09.01.2017.
• 55. Tiwari J, Babra C, Tiwari H.K. et al. (2013). Trends Intherapeutic and Prevention Strategies for Management of Bovine Mastitis: An Overview. Journal of Vaccines and Vaccination. 4 (2): 8-11.
• 56. Saat N, Yuksel M, Toraman Z, Ri̇svanli̇ A. (2016). The Efficiency of Corynebacterium Cutis lysate in Cows With Subclinical Mastitis. Research Opinions in Animal & Veterinary Sciences. 6 (3): 108-110.
• 57. Mohamed E.M, Ibrahim E.E.S, Mohamed F.S. (2013). Effect of Administration of Ultra-corn With Bivalent Foot and Mouth Disease Oil Vaccine in Calves. Veterinary World. 6 (8): 486-492.
• 58. Shalaby M, Saleh S, El-Atrash S. et al. (1992). Application of Corynebacterium Cutis Lysate as an Immune Stimulant in Cattle. Molecular Biotherapy. 4 (3): 147-150.
• 59. Amer H.A, Hashem M.A. (2008). Reproductive Performance and Viability of Newborns in Buffaloes Treated Antepartum with Viteselen and/or Ultra-corn. Slovenian Veterinary Research. 45 (2): 53-60.
• 60. Amer H.A, Badr A.M. (2008). Influence of Antepartum Administration of Immunopotentiators on Reproductive Efficacy of Buffalo and Viability of Their Newborn. Veterinaria Italiana. 44 (2): 373-382.
• 61. Er A, Dik B, Corum O. (2014). Effect of Corynebacterium Cutis Lysate on Serum Oxidative Stress and Plasma Prostaglandin f2α Metabolite Levels. Acta Scientiae Veterinariae. 42, 1-6.
• 62. Er A, Corum O, Dik B. et al. (2015). Effect of Corynebacterium Cutis Lysate Treatment on The Cytokine Levels in Sheep. European Pharma Congress, 25-27 August, Valencia-Spain.
• 63. Yilmaz Ö, Kaşikçi G. (2013). Factors Affecting Colostrum Quality of Ewes and Immunostimulation. Turkish Journal of Veterinary Animal Sciences. 37 (4): 390-394.
• 64. Yılmaz ÖT, Kaşıkçı G, Gündüz MC. (2011). Benefits of Pregnant Sheep Immunostimulation With Corynebacterium Cutis on Post-partum and Early Newborn's Life IgG Levels, Stillbirth Rate and Lamb's Weight. Small Ruminant Researc. 97 (1): 146-151.
• 65. Dik B, Dik I, Bahcivan E, Avci O. (2016). Corynebacterium Cutis Lysate Treatment Can Increase The Efficacies of PPR Vaccine. Journal of Interferon Cytokine Research. 36 (10): 599-606.
• 66. Soliman R, Reda I, Youssef S, Refai M. (1991). Studies on Factors Influencing Immune Response in Chickens. Journal of the Egyptian Veterinary Medical Association. 51, 387-400.
• 67. Hanafy M, Abdel-Rahman F, Soliman G. et al. (1995). Studies on The Efficacy of Combined Immunostimulant-antibiotic Therapy Against Experimental Mycoplasma Gallisepticum Infection in Chickens. Deutsche Tierarztliche Wochenschrift. 102 (10): 408-409.