Kuzu ve Oğlak Akut Koksidiyozisinin Tedavisinde Toltrazuril’in Tedavideki Etkinliğinin Değerlendirilmesi

Yıl 2019, Cilt: 12 Sayı: 1, 37 - 40, 30.06.2019

Mahmut Ok , Merve İder Murat Kaan Durgut Onur Ceylan , Alper Ertürk

Öz

Bu çalışmanın amacı, kuzu ve oğlak akut
koksidiyozisinin tedavisinde toltrazuril’in tedavideki etkinliğini
değerlendirmekti. Bu araştırmanın materyalini, 15-45 günlük koksidiyozisli 120
kuzu ve 20 oğlak oluşturdu. Kuzu ve oğlaklarda iştahsızlık, durgunluk, emme
refleksinde ve canlı ağırlıkta azalma, dehidrasyon ve siyah yeşilimsi
(çoğunluğunda) veya kanlı ishal gözlendi. Koksidiyozis tanısı dışkının mikroskobik
muayenesi ile kondu. Kuzu ve oğlaklara 20 mg/kg dozunda oral yolla tek doz
toltrazuril uygulandı.  120
koksidiyozisli kuzunun 115’i tedaviye cevap verirken, 5 kuzu tedaviye cevap
vermedi. 20 koksidiyozisli oğlağın 19’u tedaviye cevap verirken, 1 oğlak
tedaviye cevap vermedi. Sonuç olarak, bu çalışma kuzu ve oğlakların
koksidiyozisinin tedavisinde toltrazuril’in oldukça etkili olduğunu
göstermiştir.

Anahtar Kelimeler

Koksidiyozis, kuzu ve oğlak, tedavi, toltrazuril

Teşekkür

Bu çalışmanın yürütülmesinde yaptıkları destekten dolayı Alke İlaç firmasına teşekkürü bir borç biliriz.

The Evaluation of Therapeutic Efficacy of Toltrazuril in the Treatment of Coccidiosis of Lambs and Goat Kids

Öz

The aim of this study was to evaluate the
therapeutic efficacy of toltrazuril in the treatment of coccidiosis of lambs
and goat kids. The animal material of the study consisted of 120 lambs and 20
goat kids with coccidiosis, 15-45 days old. Clinical examination revealed
absented or decreased appetite, depression, dehydration, decrease in suckling
reflex, weight loss and black greenish (mostly) or bloody diarrhea in lambs and
goat kids with coccidiosis. Diagnosis of coccidiosis was performed by
microscopic examination.  A single dose
of toltrazuril (20 mg/kg PO) was administered to each lambs and goat kids. 115
of 120 lambs with coccidiosis responded to the therapy (95 %). Five infected
lambs did not respond to treatment. 19 of 20 goat kids with coccidiosis
responded to the therapy (95 %). One infected goat kids did not respond to
treatment. As a result, this study demonstrated that toltrazuril was found to
have more effect in the treatment of coccidiosis of lambs and goat kids.

Anahtar Kelimeler

Coccidiosis, lamb and goat kid, treatment, toltrazuril

Kaynakça

• 1. Çimtay İ, Sevgili M. (2003). Koksidiyozisli Kuzularda Tedavi Öncesi ve Sonrası Bazı Hematolojik ve Biyokimyasal Parametreler Üzerine Araştırmalar. Van Vet J. 4: 91-94.
• 2. Gauly M, Reeg J, Bauer C, Erhardt G. (2004). Influence of Production Systems in Lambs on the Eimeria Oocyst Output and Weight Gain. Small Rumin Res. 55(1-3): 159-167.
• 3. Tafti AK, Mansourian M. (2008). Pathologic Lesions of Naturally Occurring Coccidiosis in Sheep and Goats. Comp Clin Path. 17(2): 87-91.
• 4. Taylor MA, Coop R, Wall RL. (2007). Veterinary Parasitology. Third ed. p. 175-178: 189-190, Blackwell Publishing Ltd.
• 5. Turgut K, Ok M. (1997). Veteriner Gastroenteroloji. Bahçıvan-lar Basımevi. Konya.
• 6. Jalila A, Dorny P, Sani R, Salim NB, Vercruysse J. (1998). Coccidial Infections of Goats in Selangor, Peninsular Malaysia. Vet Parasitol. 74(2-4): 165-172.
• 7. Öcal N, Yagci BB, Duru SY, Kul O. (2007). Toltrazuril Treatment for Acute Clinical Coccidiosis in Hair Goat Kids: Clinical Pathological, Haematologic and Biochemical Findings. Med Wet. 63(7): 805.
• 8. Diaferia M, Veronesi F, Morganti G, Nisoli L, Fioretti DP. (2013). Efficacy of Toltrazuril 5% Suspension (Baycox®, Bayer) and Diclazuril (Vecoxan®, Janssen-Cilag) in the Control of Eimeria Spp. in Lambs. Parasitol Res. 112(S1): 163-168.
• 9. Gul A. (2007). The Prevalence of Eimeria Species in Goats in Iğdır. Turk J Vet Anim Sci. 31(6): 411-414.
• 10. Hashemnia M, Khodakaram-Tafti A, Razavi SM, Nazifi S. (2014). Hematological and Serum Biochemical Analyses in Experimental Caprine Coccidiosis. J Parasit Dis. 38(1): 116-123.
• 11. Chartier C, Paraud C. (2012). Coccidiosis due to Eimeria in Sheep and Goats, a Review. Small Rum Res. 103: 84-92.
• 12. Maratea KA, Miller MA. (2007). Abomasal Coccidiosis Associated with Proliferative Abomasitis in a Sheep. J Vet Diagn Invest. 19(1): 118-121.
• 13. Cartier C, Pellet, MP, Pors I. (1992). Effects of Toltrazuril on Oocyts Discharge and Growth in Kids with Naturally –Acquired Coccidial Infection. Small Rumin Res. 8: 171-177.
• 14. Mundt HC, Dittmar K, Daugschies A, Grzonka E, Bangoura B. (2009). Study of the Comparative Efficacy of Toltrazuril and Diclazuril Against Ovine Coccidiosis in Housed Lambs. J Parasitol Res. 105(1): 141-150.
• 15. Iqbal A, Tariq KA, Wazir VS, Singh R. (2013). Antiparasitic Efficacy of Artemisia Absinthium, Toltrazuril and Amprolium Against Intestinal Coccidiosis in Goats. J Parasit Dis. 37(1): 88-93.
• 16. Odden A, Denwood MJ, Stuen S, et al. (2018). Field evaluation of anticoccidial efficacy: a novel approach demonstrates reduced efficacy of toltrazuril against ovine eimeria spp. in Norway. Int J Parasitol Drugs Drug Resist. 8(2): 304-311.
• 17. Ghanem MM, Abd El-Raof YM. (2005). Clinical and Haemato-Biochemical Studies on Lamb Coccidiosis and Changes Fo-lowing Amprolium and Sulphadimthoxine Therapy. Benha Vet Med J. Vol. 16, No. 2.
• 18. Scala A, Varcasia A, Dore F, et al. (2014). Evaluation of Efficacy of Toltrazuril and Diclazuril in The Control of Subclinical Eimeriosis in Weaned Lambs. Small Rumin Res. 120: 242-246.
• 19. Çakmak A, Vatansever Z. (2001). Koksidiyoziste Tanı. (için-de):Coccsidiosis. Dincer Ş (Ed). Turkiye Parazitol Derg. 17: 127-132.
• 20. Dittmar K, Mundt HC, Grazonka E, Daugschies A, Bangoura S. (2010). Ovine coccidios in housed lambs in Saxony-Anhalt (Central Germany). Berl Munch Tierarztl Wochenschr. 123: 49-57.
• 21. Saratsis A, Karagiannis I, Brozos C. (2013). Lamb Eimeriosis: Applied Treatment Protocols in Dairy Sheep Production Sytems. Vet Parasitol. 196(1-2): 56-63.
• 22. Le Sueur C, Mage C, Mundt HC. (2009). Efficacy of Toltrazuril (Baycox %5 suspension) in Naturally İnfection with Pathogenic Eimeria Ssp. in Housed Lambs. Parasitol Res. 104: 1157-1162.
• 23. Veronesi P, Diaferia M, Viola O, Piergili Fioretti D. (2011). Long-term Effect of Toltrazuril on Growht Performences of Diary Heifers and Beef Calves Exposed to Natural Eimeria Zeurnii and Eimeria Bovis. Vet J. 190: 296-299.