Reproductive Physiology in Female Rats

Yıl 2019, Cilt: 12 Sayı: 2, 163 - 167, 31.12.2019

Ayşe Arzu Yiğit Gülbahar Böyük Ruhi Kabakçı

Öz

The detailed knowledge of reproductive physiology in female rats is important to set up a good model for the study of reproductive system diseases. Rats, on average, entered puberty at four weeks, followed by 4-5 days of oestrus, and it lasts to 10-12th month. With this review, the events that occurred in the reproductive systems from the birth to the term that lost their reproductive ability were tried to be explained in detail. In addition, information about ovarium cells and their secretions are given. The correct establishment of the hypothesis of studies on the reproductive system is possible if the reproductive physiology of female rats is well known.

Anahtar Kelimeler

Luteal cell, ovary, oestrogen, progesterone, rat

Dişi Ratlarda Üreme Fizyolojisi

Öz

Dişi ratlarda üreme fizyolojisinin detaylıca bilinmesi, üreme sistemi hastalıklarının çalışılması için iyi bir model oluşturmak açısından önemlidir. Ratlar, ortalama olarak 4 haftalıkken pubertaya girer ve 4-5 gün kadar sürecek olan östrus başlar ve 10-12. aya kadar devam eder. Hazırlanan bu derleme ile dişi ratların doğumdan üreme yeteneklerini kaybettikleri döneme kadar üreme sistemlerinde gelişen olaylar detaylıca anlatılmaya çalışılmıştır. Ayrıca ovaryumda bulunan hücreler ile bu hücrelerin salgıları hakkında bilgi verilmiştir. Üreme sistemi ile ilgili yapılacak çalışmaların hipotezlerinin doğru kurulabilmesi, dişi ratların üreme fizyolojilerinin iyi bilinmesi ile mümkündür.

Anahtar Kelimeler

Luteal hücre, ovaryum, östrojen, progesteron, rat

Kaynakça

• 1. Urbanski HF, Ojeda SR. (1985). The Juvenile-Peripubertal Transition Period in the Female Rat: Establishment of a Diurnal Pattern of Pulsatile Luteinizing Hormone Secretion. Endocrinology. 117(2): 644-649.
• 2. Ojeda SR, Urbanski HF, Ahmed CE. (1986). The Onset of Female Puberty: Studies in the Rat. In: Proceedings of the 1985 Laurentian Hormone Conference, 42, pp. 385-442. Academic Press, Boston, USA.
• 3. Yılmaz B. (2016). Dişi Üreme Fizyolojisi. (içinde) Vander İnsan Fizyolojisi: Vücut Fonksiyon Mekanizmaları, Widmaier EP, Raff H, Strang KT (editörler). Baskı 13. s. 624. çev. Tuncay Özgünen, Güneş Tıp Kitapevleri, Ankara, Türkiye.
• 4. Satie AP, Mazaud-Guittot S, Seif I, et al. (2011). Excess Type I Interferon Signaling in the Mouse Seminiferous Tubules Leads to Germ Cell Loss and Sterility. J Biol Chem. 286(26): 23280-23295.
• 5. Petroianu A, de Souza Vasconcellos L, Alberti LR, Buzelin Nunes M. (2005). The Influence of Venous Drainage on Autologous Ovarian Transplantation. J Surg Res. 124(2): 175-179.
• 6. Faith RE, Hessler JR. (2006). Housing and Environment. In: The Laboratory Rat. Weisbroth SH, Franklin CL (eds). 2nd ed. pp. 303-337. Academic Press, Burlington, USA.
• 7. Hubscher CH, Brooks DL, Johnson JR. (2005). A Quantitative Method for Assessing Stages of the Rat Estrous Cycle. Biotech Histochem. 80(2): 79-87.
• 8. Levine JE, Powell KD. (1989). Microdialysis for Measurement of Neuroendocrine Peptides. In: Methods in Enzymology. pp. 166-181. Academic Press, Elsevier, USA.
• 9. Ackland JF, D'Agostino J, Ringstrom SJ, et al. (1990). Circulating Radioimmunoassayable Inhibin During Periods of Transient Follicle-Stimulating Hormone Rise: Secondary Surge and Unilateral Ovariectomy. Biol Reprod. 43(2): 347-52.
• 10. Foster PMD, Gray Jr E. (2010). Toxic Responses of the Repro-ductive System. In: Casarett & Doull's Essentials of Toxicology. Klaassen CD, Watkins JB (eds), 2nd ed, pp. 279-293. Mc Graw Hill, New York, USA
• 11. Peters H, McNatty KP. (1980). The Ovary: A Correlation of Structure and Function in Mammals. 1st ed. Univ of California Press, USA.
• 12. Rao RP, Kaliwal BB. (2002). Monocrotophos Induced Dysfunc-tion on Estrous Cycle And Follicular Development in Mice. Ind Health. 40(3):237-44.
• 13. Accialini P, Hernandez S, Abramovich D, Tesone M. (2016). The Life Cycle of the Corpus Luteum. In: The Rodent Corpus Lu-teum. Meidan R (ed). 2nd ed. pp 117-131 Springer, Cham, Switzerland
• 14. Ross M, Wojciech P. (2011). Histology: A Text and Atlas: With Correlated Cell and Molecular Biology. 6th ed. Wolters Kluwer/Lippincott Williams & Wilkins Health, USA.
• 15. Gibori G, Khan I, Warshaw ML, et al. (1988). Placental-Derived Regulators and the Complex Control of Luteal Cell Function. In: Proceedings of the 1987 Laurentian Hormone Conference, 44 ed. pp. 377-429. Academic Press, Boston, USA.
• 16. Gunnet JW, Freeman ME. (1983). The Mating-induced Release of Prolactin: A Unique Neuroendrocine Response. Endocr Rev. 4(1): 44-61.
• 17. Milvae R, Hinckley S, Carlson J. (1996). Luteotropic and Lu-teolytic Mechanisms in the Bovine Corpus Luteum. Therioge-nology. 45(7): 1327-1349.
• 18. Nelson SE, McLean MP, Jayatilak PG, Gibori G. (1992). Isola-tion, Characterization, and Culture of Cell Subpopulations Forming the Pregnant Rat Corpus Luteum. Endocrinology. 130(2): 954-966.
• 19. Arikan S, Yigit A. (2001). Size Distribution of Bovine Steroido-genic Luteal Cells during Pregnancy. Anim Sci. 73(2): 323-327.
• 20. Arikan S, Yigit AA. (2002). Size Distribution of Steroidogenic and Non-Steroidogenic Ovine Luteal Cells Throughout Preg-nancy. Anim Sci. 75(3): 427-432.
• 21. Arikan S, Yigit AA. (2003). Changes in the Size Distribution of Goat Steroidogenic Luteal Cells during Pregnancy. Small Ruminant Res. 47(3): 227-231.
• 22. Arikan S, Yigit AA, Kalender H. (2009). Size Distribution of Luteal Cells during Pseudopregnancy in Domestic Cats. Reprod Domest Anim. 44(5): 842-845.
• 23. Hansel W, Blair RM. (1996). Bovine Corpus Luteum: A Historic Overview and Implications for Future Research. Theriogeno-logy. 45(7): 1267-1294.
• 24. Pate JL, Johnson-Larson CJ, Ottobre JS. (2012). Life or Death Decisions in the Corpus Luteum. Reprod Domest Anim. 47 (4): 297-303.
• 25. Miyamoto H, Yoshida E, Otsuka Y, Ishibashi T. (1987). Ovarian Follicular Development in the Pregnant Rat. Japanese Journal of Animal Reproduction (Japan). 3: 117-122.
• 26. Weisz J, Ward IL. (1980). Plasma Testosterone and Progeste-rone Titers of Pregnant Rats, Their Male and Female Fetuses, and Neonatal Offspring. Endocrinology. 106(1): 306-316.
• 27. Hvid H, Thorup I, Sjogren I, Oleksiewicz MB, Jensen HE. (2012). Mammary Gland Proliferation in Female Rats: Effects of the Estrous Cycle, Pseudo-Pregnancy and Age. Exp Toxicol Pathol. 64(4): 321-332.
• 28. Goldman JM, Murr AS, Cooper RL. (2007). The Rodent Estrous Cycle: Characterization of Vaginal Cytology and its Utility in Toxicological Studies. Birth Defects Res B Dev Reprod Toxicol. 80(2): 84-97.
• 29. Niswender GD, Nett TM. (1998). The corpus luteum and its control. In: The Physiology of Reproduction. Knobil E, Neill J (eds.). 4th ed, pp. 489- 525. New York, Raven Press, USA.
• 30. Matsuyama S, Takahashi M. (1995). Immunoreactive (Ir)-Transforming Growth-Factor (TGF)-Beta in Rat Corpus-Luteum - Ir-TGF Beta Is Expressed by Luteal Macrophages. Endocr J. 42(2): 203-217.
• 31. Darıyerli N. (2011). Gebelik Öncesi Kadın Fizyolojisi ve Kadın Hormonları. (içinde) Guyton ve Hall Tıbbi Fizyoloji. Hall JE, (editör). Baskı 12. s. 993. Nobel Tıp Kitabevleri, İstanbul, Türkiye.
• 32. Cora MC, Kooistra L, Travlos G. (2015). Vaginal Cytology of the Laboratory Rat and Mouse: Review and Criteria for the Staging of the Estrous Cycle Using Stained Vaginal Smears. Toxicol Pathol. 43(6): 776-793.
• 33. Böyük G. (2017). Adacık Hücreleri ile Kokültüre Edilen Luteal Hücrelerin, Hücre Canlılığı, Revaskülarizasyon ve İmmun Yanıta Etkileri. Doktora tezi. YÖK Ulusal Tez Merkezi: Kırıkkale Üniversitesi Sağlık Bilimleri Enstitüsü, s. 41 Kırıkkale-Türkiye.