The Relationship Between Serum Zinc Levels and Tumor Markers in Hemodialysis Patients

Abstract

The incidence of neoplasia is increased in end-stage renal disease (ESRD) patients. Zinc (Zn) deficiency is associated with neoplasia and also commonly seen in ESRD patients. However, the data regarding the relationship between Zn levels and tumor markers is scant in this population. We aimed to investigate the relationship between Zn levels and tumor markers in hemodialysis patients. Twenty-six hemodialysis patients (11 male, 15 female, mean age 41.6±14.3 years) and 11 healthy subjects (6 male and 5 female, mean age 38.7±7.2 years) were included. Serum Alpha fetoprotein (AFP), carcinoembriyonic antigen (CEA), CA 19-9, CA 15-5, CA 125, beta subunit of human corionic gonadotrophin (β-HCG) and beta-2 microglobulin (β2M) and Zn levels were measured. Data were analysed by Student’s t test. Serum Zinc levels were significantly lower in ESRD patients (group 1) compared to healthy subjects (group 2) (p<0.0001, for all). Serum CEA and β2M levels were also significantly higher in group 1 patients compared to group 2 subjects (p<0.005, p<0.0001, respectively). Serum Ca15-3 and CA-125 levels were found to be significantly lower in group 1 patients compared to group 2 subjects (p<0.005, p<0.001, respectively). There were no statistically significant difference in terms of serum CA 19-9, β-HCG and AFP between group 1 and group 2 patients. In group 1 patients, there was a negative correlation between serum Zn levels and AFP, while a positive correlation was obsorved between serum Zn levels and CA15-3. The measurement of AFP may be beneficial in HD patients. Further studies are needed

Keywords

• Hemodialysis, zinc, tumor markers

The Relationship Between Serum Zinc Levels and Tumor Markers in Hemodialysis Patients

Öz

Son dönem böbrek yetersizliği (SDBY) bulunan hastalarda neoplazi insidansı artmıştır. Çinko (Zn) eksikliği neoplazi gelişimi ile ilişkilidir ve bu durum SDBY hastalarında sıklıkla görülmektedir. Bununla birlikte bu populasyonda serum Zn düzeyleri ile tumor belirteçleri arasındaki ilişki bilinmemektedir. Çalışmamızda hemodiyaliz hastalarında serum Zn düzeyleri ile tümör belirteçleri arasındaki ilişkiyi araştırmayı hedefledik. Çalışmaya 26 hemodiyaliz hastası (11 erkek, 15 kadın, yaş ortalaması 41.6±14.3 yıl) ve 11 sağlıklı birey (6 erkek, 5 kadın, yaş ortalaması 38.7±7.2) dahil edildi. Serum alfa fetoprotein (AFP), karsinoembriyonik antijen (CEA), CA 19-9, CA 15-5, CA 125, beta HCG, beta-2 mikroglobulin (β2M) ve Zn değerleri ölçüldü. Veriler Student t test ile analiz edildi. Serum Zn düzeyleri SDBY hastalarında (grup 1) sağlıklı bireylere (grup 2) oranla anlamlı olarak düşük saptandı (p<0.0001). Serum CEA ve β2M düzeyleri grup 1 hastalarda anlamlı olarak yüksekti (sırasıyla, p<0.005 ve p<0.0001). Serum Ca15-3 and CA125 düzeyleri ise grup 1 hastalarda anlamlı olarak düşük saptandı (sırasıyla, p<0.005 ve p<0.001). Her iki grup arasında serum CA 19-9, β-HCG ve AFP açısından anlamlı fark yoktu. Grup 1 hastalarda serum Zn seviyesi ile AFP arasında pozitif korelasyon ve CA 15-3 arasında negatif korelasyon vardı. Hemodiyaliz hastalarında AFP ölçümü faydalı olabilir. Bu konuyla ilgili detaylı çalışmalara ihtiyaç vardır

Anahtar Kelimeler

• Hemodiyaliz, çinko, tümör belirteçleri

Kaynakça

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