MCV and MCH Values in Coronary Artery Patients with Positive Gensini Score

Abstract

This study aims to research whether gensini scoring of white blood cells and their subgroups and hemoglobin (Hb), hematocrit (Htc), erythroscyte and their computational tests are related, through retrospectively evaluating complete blood cell counts of patients who underwent coronary angiography with coronary artery disease (CAD) early diagnosis. Files of 267 patients, 113 women and 154 men over the age of 18, who came to Namık Kemal University Research and Practice Hospital in August 2011 and January 2012 and underwent coronary angiography with CAD early diagnosis, were scanned retrospectively. Patients were grouped as angio-negative (ANG) and angio-positive (APG) according to coronary angiography results. Gensini Scoring was done in APG patients according to angiography results. Hemogram values studied before coronery angiography as well as age, gender and other diseases of patients in both groups were recorded. When ANG and APG erythrocytic parameters were compared, Hb and Htc values did not differ significantly between groups while a significant difference was observed in mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) values. White blood cell count, neutrophil, lymphocyte and monocyte counts were significantly higher in APG compared to ANG. Eosinophil and basophil values and thrombocytic parameters did not differ significantly between groups. A positive correlation was observed between Gensini Score and MCV, MCH, WBC (leukocyte), neutrophil, lymphocyte and monocyte. Consequently, our findings suggest that erythrocyte has a role in CAD pathogenesis like other blood cells or factors in CAD pathogenesis might affect erythrocyte morphology.

Keywords

• Gensini score, coroner artery disease, erythrocyte indices, leukocyte count

MCV and MCH Values in Coronary Artery Patients with Positive Gensini Score

Öz

Bu çalışma koroner arter hastalığı (KAH) ön tanısı konulup, koroner anjiyografisi yapılmış hastaların tam kan sayım sonuçları retrospektif olarak değerlendirilerek; hemoglobin (Hb), hematokrit (Htc), eritrosit ve bunlar üzerinden yapılan hesaplamalı testler ile beyaz küre ve alt gruplarının gensini skorlaması ile ilişkisinin olup olmadığını araştırmak amacı ile planlandı. Çalışmamızda Ağustos 2011 ile Ocak 2012 tarihleri arasında Namık Kemal Üniversitesi Uygulama ve Araştırma Hastanesi Kardiyoloji Kliniğine KAH ön tanısı ile gelen ve koroner anjiyografi yapılan 18 yaş üstü 113 kadın ve 154 erkek toplam 267 hastanın retrospektif dosya taraması yapıldı. Koroner anjiyografi sonuçlarına göre hastalar anjiyo negatif grup (ANG) ve anjiyo pozitif grup (APG) şeklinde ikiye ayrıldı. APG hastalarda anjiyografi sonuçlarına göre Gensini Skorlaması yapıldı. Her iki grubun koroner anjiyografi öncesi çalışılan hemogram değerleri ile birlikte yaşı, cinsiyeti ve diğer hastalıkları kaydedildi. ANG ile APG eritrositik parametreler karşılaştırıldığında eritrosit, Hb ve Htc değerlerinde gruplar arasında fark görülmezken ortalama eritrosit hacmi (MCV) ve ortalama hemoglobin konsantrasyonu (MCH) değerleri arasındaki farkın istatistiksel olarak anlamlı olduğu gözlendi. Beyaz küre sayısı, nötrofil, lenfosit ve monosit sayıları APG’da ANG göre anlamlı derecede yüksekti. Eozinofil ve bazofil değerlerinde gruplar arasında anlamlı bir fark gözlenmedi. Trombositik parametrelerde de iki grup arasında anlamlı fark tespit edilmedi. Gensini Skoru ile MCV, MCH, WBC (lökosit), nötrofil, lenfosit ve monosit arasında pozitif korelasyon olduğu gözlendi. Sonuç olarak bulgularımız, eritrositin de diğer kan hücreleri gibi KAH patogenezinde rol aldığını ya da KAH patogezinde rol alan faktörlerin eritrosit morfolojisini etkilediğini desteklemektedir

Anahtar Kelimeler

• Gensini skoru, koroner arter hastalığı, eritrosit indeksi, lökosit sayısı

Kaynakça

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