Effect of Hemodialysis on Serum Copper and Zinc Levels in Kidney Disease Patients

Öz

For human beings trace elements are essential nutrients with a gamut of functions. Available data regarding trace element status in hemodialysis patients are contradictory. The present study was aimed to investigate possible existence of trace element disturbances in uremic patients undergoing dialysis treatment. Blood samples of forty hemodialysis patients and twenty healthy controls were analyzed for quantitation of copper and zinc. The study revealed that serum copper and zinc concentrations in hemodialysis patients are distinctly decreased compared to that of healthy controls. Abnormalities of trace elements are primarily the result of uremia, and they may be further exacerbated by the dialysis procedure.

Anahtar Kelimeler

• Copper, zinc, hemodialysis

Effect of Hemodialysis on Serum Copper and Zinc Levels in Kidney Disease Patients

Öz

Insan için eser elementler bir çok fonksiyonu için gerekli besin öğeleridir(???). Hemodiyaliz hastalarında eser elementlerin durumu ile ilgili veriler çelişkilidir. Bu çalışmada diyaliz programında olan üremik hastalarda eser element bozukluklarının değerlendirilmesi amaçlandı. Çalışmaya kırk hemodiyaliz hastası ve kontrol grubu olarak yirmi sağlıklı birey alınarak kan örneklerinde bakır ve çinko düzeyleri kantitatif olarak analiz edildi. Sonuç olarak hemodiyaliz hastalarında serum bakır ve çinko konsantrasyonlarının sağlıklı kontrol grubu ile karşılaştırıldığında belirgin azaldığı saptandı. Eser element düzeylerindeki anormallik primer olarak üremeye bağlı olarak ortaya çıkabilir ve diyaliz bu anormalliğin şiddetlenmesine neden olabilir

Anahtar Kelimeler

• Bakır, çinko, hemodiyaliz

Kaynakça

1. Harold H. Trace elements in uremia and hemodialysis. Am J Clin Nutr 1980;33:1501-8.
2. Zima T, Tesar V, Mestek O, Nemecek K. Trace elements in endstage renal disease. 2. Clinical implication of trace elements. Blood Purif 1999, 17:187-98. 156
3. Zima T, Mestek O, Nemecek K, et al. Trace elements in he- modialysis and continuous ambulatory peritoneal dialysis patients. Blood Purif 1998, 16:253-60.
4. D'Haese PC, De Broe ME. Adequacy of dialysis: trace el- ements in dialysis fluids. Nephrol Dial Transplant 1996, 11(Suppl 2):92-7.
5. Shrimpton R, Gross R, Hill I, Young M. Zinc deficiency: what are the most appropriate interventions? BMJ 2005; 330:347-9.
6. Suadicani P, Hein HO, Gyntelberg F. Serum selenium concentration and risk of ischaemic heart disease in a prospective cohort study of 3000 males. Atherosclerosis 1992; 96:33-42.
7. Smythe WR, Alfrey AC, Craswel PW, et al. Trace ele- ments abnormalities in chronic uremia. Ann Intern Med 1982;96:302-10
8. Brod J and Sirota JH. Determination of creatinine in blood. J Clin Invest 1948; 27: 645.

9. Bonsnes RW, Taussky HH. Determination of creatinine in urine. Varley’s Practical Clinical Biochemistry 4th edi- tion, New York, 1988, p:197-8.
10. Lin TH, Chen JG, Liaw JM, Juang JG. Trace elements and lipid peroxidation in uremic patients on hemodialysis. Biol Trace Element Res 1996;51:277-83.
11. Ongajooth L, Ongajyooth S, Likidilid A, Chantachum Y, Shayakul C, Nilwarangkur S. Role of lipid peroxidation, trace elements and antioxidant enzymes in chronic renal disease patients. J Med Assoc Thai 1996;79:791-800.
12. Hosokawa S, Imai T, Nishia T. Changes in copper and zinc in hemodialysis patients, EDTA - ERA Abstracts, 1984p 81.
13. Vanholder R,Conelis R, Dhondt A, Lameire N. The role trace elements in uremic toxicity.Nephrol Dial Tranplant 2002;17:2-8.
14. Prasad AS. Zinc in growth and development and spectrum of human zinc deficiency. J Am Coll Nutr 1988; 7:377-84.
15. Rink L, Gabriel P. Zinc and the immune system. Proc Nutr Soc 2000; 59:541-52.
16. Shankar AH, Prasad AS. Zinc and immune function: the biological basis of altered resistance to infection. Am J Clin Nutr 1998, 68(Suppl 2):447S-63S
17. Collins AJ, Kasiske B, Herzog C, et al. Excerpts from the United States Renal Data System 2004 annual data report: atlas of endstage renal disease in the United States. Am J Kidney Dis 2005; 45(Suppl 1):A5-7.
18. Markovits PM, Sankey AW, James DK, McCabe R, Mahomed K, Golding J. Zinc taste test and postnatal depression. Br J Psychiatry 1990; 156:451-2.
19. Ortega RM, Requejo AM, Andres P, et al. Dietary intake and cognitive function in a group of elderly people. Am J Clin Nutr 1997; 66:803-809.
20. Prasad AS, Rabbani P, Aaasii A, Bowersox E, Spivey FMR. Experimental zinc deficiency in humans. Ann Intern Med 1978; 89:483-9.
21. Prasad AS, Oberlea D. Changes in the activities of zinc dependent enzymes in zinc deficient tissue of rats, J Appi Physiol 1971;31:842-6.
22. Mahajan SK, Prasad AS, Rabbani P, Brigo WA, McDonald FD. Zinc metabolism in uremia. J Lab Clin Med 1979;94:693-8.
23. Thompson NM, Stevens BJ, Humpherey TS, Atkins RC. Comparison of trace elements in peritoneal dialysis, he- modialysis and uremia. Kidney Int 1983;23:9-14.