Association of IL-10 and IL-6 Gene Polymorphisms with Type 2 Diabetes Mellitus among Egyptian Patients

Öz

Recent findings indicate that certain cytokines are capable of interfering with insulin sensitive glucose uptake and induce insulin resistance. To test for the association of IL-10–1082 and IL-6–174 genetic polymorphisms with type 2 diabetes mellitus in Egyptian patients. Participants included 69 cases with type 2 DM (31 males and 38 females) with a median age of 57 years in addition to 98 healthy unrelated controls from the Nile Delta region, Egypt. Compared to controls, cases with type 2 diabetes mellitus showed a highly significant increase in the frequency of IL-10–1082 GG genotype (p

Anahtar Kelimeler

• IL-10, IL-6, gene polymorphism, type 2 diabetes, Egypt

Association of IL-10 and IL-6 Gene Polymorphisms with Type 2 Diabetes Mellitus among Egyptian Patients

Öz

Son yıllarda bazı sitokinlerin insülin duyarlı glikoz alınımı ile ilişkiye girebilme ile birlikte insülin direnci meydana getirebilme yeteneğine sahip olduğu bildirilmiştir. Mısırlı tip 2 diabetli hastalarda L-10–1082 and IL-6–174 genetik poliformizm ilişkisini test etmek için ortalama yaşı 57 olan 69 hasta (31 E ve 38 K) ve sağlıklı 98 kişi Nil deltasından çalışmaya alındı. Kontrol grubu ile karşılaştırıldığında tip 2 diabetli hastalar yüksek oranda L-10–1082 GG genotipe (p<0.001, OR = 11.24), IL-10–1082 G allele (p<0.001, OR = 2.2) ve düşük oranda IL-10–1082 GA genotype (p<0.001, OR = 0.22) sahip olduğu gösterilmiştir. Diğer bir sonuç, IL-6–174 CC genotipi sıklıkla diabetli grupta yüksekti (p<0.001, OR = 5.41), IL-6–174 GC ise düşüktü. IL-6–174 GC genotipinde ise her grupta anlamlı farklılık göstermedi. Diğer bir sonuç ise IL-6–174 CC genotip sıklığı diabetikli hastalarda oldukça yüksekti (p<0.001, OR = 5.41), bunun aksine IL-6–174 GC genotipi anlamlı derecede düşüktü (p=0.005, OR = 0.31). G or C allelic sıklığı her iki grupta aynı idi (p>0.05). IL-10–1082 GG ve IL-6–174 CC genotipi ile ilişkili poliformizm Mısır'lı hastalarda bir risk faktörü olabilir

Anahtar Kelimeler

• IL-10, IL-6, gen poliformizmi, tip 2 diabet, Mısır

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