Effects of Fentanyl with Levobupivacaine on Cognitive Functions and Cerebral Oxygenation

Abstract

Preoperative risk assessment may fail in most patients who may be exposed to postoperative neurological sequelae. The aim of this study was to assess the effects of Fentanyl added to epidural levobupivacaine on cerebral oxygenation and cognitive functions. There was a negative correlation between age and MMT, and a positive correlation between SpO2 and MMT. MMT scores of Group 2 at postoperative first hour and fifth hours were lower than those of Group 1. It was concluded that while fentanyl added to epidural local anesthetic had no effect on hemodynamic parameters, SpO2, and right-left cerebral oxygen saturation, and although it may have caused a decrease in MMT scores in the early postoperative period, it did not cause impairment in cognitive functions.

Keywords

• Epidural anesthesia, fentanyl, levobupivacaine, cognitive function, cerebral oxygenation

Effects of Fentanyl with Levobupivacaine on Cognitive Functions and Cerebral Oxygenation

Öz

Postoperatif nörolojik sekele maruz kalabilen çoğu hastada preoperatif risk değerlendirmesi yetersiz kalabilir. Bu çalışmanın amacı epidural levobupivakaine fentanilin eklenmesinin serebral oksijen ve kognitif fonksiyonlara etkisini araştırmaktır. Yaş ile MMT arasında negatif, SPO2 ile MMT arasında pozitif korelasyon vardı. Postoperatif 1 ve 5. saatte Grup 2 MMT skorları Grup birinkinden düşüktü. Epidural lokal anesteziye fentanilin eklenmesi hemodinamik parametreleri, oksijenasyonu ve sağ-sol serebral oksijenasyonu etkilemediği, erken postoperatif peryodda MMT skorlarında azalma neden olmasına rağmen kognitif fonksiyonlarda bir bozukluk meydana getirmedi

Anahtar Kelimeler

• Epidural anestezi, fentanil, levobupivakaine, kognitif fonksiyon, serebral oksijenasyon

Kaynakça

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