OXIDATIVE STRESS AND ANTIOXIDANT STATUS IN BRONCHOALVEOLAR LAVAGE FLUID, PLASMA AND ERYTHROCYTE OF CRITICALLY MIXED ILL WITH RESPIRATORY FAILURE

Öz

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Anahtar Kelimeler

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OXIDATIVE STRESS AND ANTIOXIDANT STATUS IN BRONCHOALVEOLAR LAVAGE FLUID, PLASMA AND ERYTHROCYTE OF CRITICALLY MIXED ILL WITH RESPIRATORY FAILURE

Abstract

Aim: Increased oxidative stress is a significant part of pathogenesis of various lung diseases. In this trial, it is aimed to determine the role of oxidative stress in patients receiving mechanical ventilation for respiratory failure (RF). Methods: The oxidative stress was evaluated by determining plasma, bronchial fluid and erythrocyte levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), ascorbic acid, alpha-tocopherol, uric acid (UA) and nitric oxide (NO) in 25 critically ill patients with RF. Twenty five patients without RF was evaluated as control group. Results: Oxidative stress (MDA, NO) levels of plasma, erythrocyte and BAL fluid in mixed critically ill with respiratory failure were higher than control group. Antioxidant levels of plasma, erythrocyte and BAL fluid in mixed critically ill with respiratory failure were lower than control group. In all parameters, there was no statistically difference as exitus and survivors in critically mixed patients. Conclusion: Oxidative stress was higher in respiratory failure than control group. The aim of the present study was to investigate the status of oxidative stress and antioxidant in mixed critically ill patients with respiratory failure as assessed by the malondialdehyde (MDA), NO, SOD, GSH-Px, vit C, vit E and uric acid measurements in bronchoalveolar lavage (BAL), erythrocyte and plasma.MATERIALS AND METHODS A total 50 subjects were examined, 25 with respiratory failure (average 65.6±12.7 years, 17 males and 8 females) and 25 patients without respiratory failure (average 55.4±9.36 years, 19 males and 6 females). The patients Table 1. Characteristics of patients and control groupMixed critically ill patients

Keywords

• Respiratory failure, oxidative stress, antioxidant status

Kaynakça

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