Evaluation of the Mean Platelet Volume in Children with Juvenile Idiopathic Arthritis

Yıl 2014, Cilt: 11 Sayı: 4, 262 - 267, 01.12.2014

Velat Şen Aydın Ece Ünal Uluca Ali Güneş İlhan Tan Tuba Tuncel Fesih Aktar Buğra Yıldırım

https://doi.org/10.15197/sabad.1.11.83

Öz

Juvenile idiopathic arthritis (JIA) is the most common chronic inflammatory arthritis in children. Mean platelet volume (MPV) is an indicator of platelet size and has been investigated as an inflammation marker in several diseases. This study was designed to investigate the MPV values in patients with JIA and healthy subjects, and determine the correlation between MPV, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR). The hospital records of a total of 40 children with JIA, diagnosed using the International League of Associations for Rheumatology (ILAR) criteria, and 40 healthy controls were enrolled into the study. White blood cell count (WBC), platelet count, CRP, ESR, and MPV levels were retrospectively recorded. Children with JIA had significantly higher MPV values (8.28±1.12 fL) compared to the control group (7.53±1.07 fL) (p=0.003). Significant correlations were found between MPV, ESR, and CRP in the JIA group (r=0.676, p

Anahtar Kelimeler

Children, juvenile idiopathic arthritis, mean platelet volume, inflammation

Evaluation of the Mean Platelet Volume in Children with Juvenile Idiopathic Arthritis

Öz

Juvenil idyopatik artrit (JİA) çocuklarda en sık görülen kronik enflamatuvar artrittir. Ortalama platelet hacmi (OPH) platelet büyüklüğünün bir göstergesidir ve çeşitli hastalıklarda bir enflamasyon belirteci olarak araştırılmıştır. Bu çalışma JİA’ lı hastalarda ve sağlıklı bireylerde OPH düzeylerini araştırmak ve OPH, C-reaktif protein (CRP) ve eritrosit sedimantasyon hızı (ESR) arasındaki ilişkiyi belirlemek için tasarlanmıştır. Bu çalışmaya Uluslararası Romatoloji Dernekleri Ligi (ILAR) kriterlerine göre JIA tanısı konan 40 çocuğun hastane kayıtları ve 40 sağlıklı kontrol grubu dahil edildi. Beyaz kan hücresi sayısı (WBC), trombosit sayısı, CRP, ESH ve OPH düzeyleri retrospektif kaydedildi. JIA'lı çocuklarda OPH değerleri (8.28±1.12 fL) kontrol grubuna(7.53±1.07 fL) göre anlamlı derecede yüksek idi (p=0.003). JIA grubunda OPH ile ESR ve CRP arasında anlamlı korelasyon bulunmuştur (r = 0.676, p <0.001 ve r = 0.430, p <0.006). Buna ek olarak, JİA’lı hastalarda OPH ile trombosit sayımı arasında negatif korelasyon bulunmuştur (r = -0,818, p <0.001). Hasta ve kontrol grubu arasında WBC değerleri açısından anlamlı bir fark yoktu (p> 0.05). Bizim sonuçlarımız, pediatrik JİA hastalarında OPH düzeylerinin yararlı bir enflamasyon belirteci ve ateroskleroz riski için bir prognostik faktör olabileceğini düşündürmektedir

Anahtar Kelimeler

Çocuk, jüvenil idyopatik artrit, ortalama trombosit hacmi, enflamasyon

Kaynakça

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