Creutzfeldt-Jakob Disease

Yıl 2014, Cilt: 11 Sayı: 3, 206 - 208, 01.09.2014

Valerio Massimo Magro

https://doi.org/10.15197/sabad.1.11.73

Öz

Creutzfeldt-Jakob disease is the most common human prion pathology. The case report we describe is emblematic of this disease in its form of onset and progression. We have reported the symptoms and the diagnostic possibilities: a 82 years old man accused suddenly confusion, agitation, memory impairment with rapid progression of cognitive decline and psychiatric signs and the appearance of other neurological deficits that led the patient quickly to coma leading to death. Then, the pathological examination clarified the nature of patient's medical and it allowed players to make the diagnosis.

Anahtar Kelimeler

General practitioner, dementia, Creutzfeldt-Jakob disease

Creutzfeldt-Jakob Disease

Öz

Creutzfeldt-Jakob hastalığı en yaygın insan prion patolojidir. Biz bu olgu sunumunda hastalığın başlangıcı ve ilerlemesini sembolik olarak sunduk. Biz hastanın semptom ve tanısal işlemlerini bildirdik. Bunlar; ani gelişen konfüzyon ile gelen 82 yaşında erkek hasta, ajitasyon , kognitif bozulma ile birlikte hafıza bozukluğu, psikiyatrik belirtiler ve ölüme neden olacak koma ya götürecek nörolojik defisitlerin bulunması. Patolojik inceleme ile hastanın tanısı konuldu

Anahtar Kelimeler

Pratisyen hekim, demans, Creutzfeldt-Jakob hastalığı

Kaynakça

• Vergani C, Lucchi T. Note pratiche di diagnosi e terapia per l’anziano. Seconda edizione: 49-65. Elsevier. 2008
• Soubelet A, Salthouse TA. Correlates of level and change in the Mini-Mental State Examination. Psychol Asess 2011; 23(4): 811-8
• Pangman VC, Sloan J, Guse L. An examination of psy- chometric properties of the mini-mental state exami- nation and the standardized mini-mental state exami- nation: implications for clinical practice. Appl Nurs Res 2000;13(4).209-13
• Dellasega C, Morris D. The MMSE to assess the cogni- tive state of elders. Mini-Mental State Examination. J Neurosci Nurs 1993; 25(3):147-52
• Erkinjuntti T, Sulkava R, Wikström J, Autio L. Short Portable Mental Status Questionnaire as a screening test for dementia and delirium among the elderly. J Am Geriatr Soc 1987; 35(5):412-6
• Pfeiffer E. A short portable mental status questionnaire for the asessment of organic brain deficit in elderly pa- tients. J Am Geriatr Soc 1975 Oct;23(10):433-41
• Hachinski V, Oveisgharan S, Romney AK, Shankle WR. Optimizing the Hachinski Ischemic Scale. Arch Neurol 2012;69(2):169-75.
• Chitravas N, Jung RS, Kofskey DM, Blevins JE, Gambetti P, Leigh RJ, Cohen ML. Treatable neurological disorders misdiagnosed as Creutzfeldt-Jakob disease. Ann Neurol. 2011;70(3):437-44.
• Van Everbroeck B, Dobbeleir I, De Waele M, De Deyn P, Martin JJ, Cras P. Differential diagnosis of 201 pos- sible Creutzfeldt-Jakob disease patients. J Neurol 2004;251(3):298-304.
• Tschampa HJ, Neumann M, Zerr I, et al. Patients with Alzheimer's disease and dementia with Lewy bodies mis- taken for Creutzfeldt-Jakob disease. J Neurol Neurosurg Psychiatry 2001;71(1):33-9.
• Seipelt M, Zerr I, Nau R, et al. Hashimoto's encephalitis as a differential diagnosis of Creutzfeldt-Jakob disease. J Neurol Neurosurg Psychiatry 1999;66(2):172-6.
• Castillo P, Woodruff B, Caselli R, et al. Steroid-Responsive Encephalopathy Associated With Autoimmune Thyroiditis. Arch Neurol 2006;63:197-202
• Gençer AG, Pelin Z, Küçükali Cİ, Topçuoğlu OB, Yilmaz N. Creutzfeldt-Jakob disease. Psychogeriatrics 2011;11(2):119-24.
• Zerr I, Kallenberg K, Summers DM, et al. Updated clini- cal diagnostic criteria for sporadic Creutzfeldt-Jakob dis- ease. Brain 2009;132(Pt 10):2659-68.
• Schröter A, Zerr I, Helkel K, et al. Magnetic Resonance Imaging in the Clinical Diagnosis of Creutzfeld-Jakob Disease. Arch Neurol 2000;57: 1751-7
• Sideri G, Pasquinelli S. Le malattie prioniche:1-12. Aracne Editrice 2008
• Peruzza S, Zanusso G, Bissoli E, et al. Sporadic Creutzfeldt- Jakob disease. G Gerontol. 2004; 52: 60-7
• Gozke E, Erdal N, Unal M. Creutzfeldt-Jacob Disease: a case report. Cases J 2008 9;1(1):146