The Chromophobe Renal Cell Carcinoma with Sarcomatoid Differentiaiton

Yıl 2014, Cilt: 11 Sayı: 12, 14 - 17, 21.03.2016

Sefa Resim Sevgi Bakaris Rana Citil Can Benlioglu Erkan Efe

https://doi.org/10.15197/sabad.1.11.21

Öz

We present a rare case of a 52-year-old woman with a chromofobe renal cell carcinoma that had sarcomatoid components. The tumor, 70x60mm in size, was incidentally found by abdominal ultrasonography. An abdominal computed tomography demonstrated a well-demarcated solid tumor arising from the upper pole of the right kidney. Histologically, the tumor was composed of two intermixed distinct morphologic components: a chromophobe renal cell carcinoma and a high-grade spindle cell sarcoma. There was a sarcomatoid area composed of highly atypical spindle cells intermingled with rhabdoid cells. A unique histological finding of this tumor was the presence of calcification and psammoma body formation throughout the tumor. We think that this case supports the existence of a tumor progression pathway from chromofob to sarcomatoid renal cell carcinoma. A literature review on sarcomatoid chromofobe renal cell carcinoma with calcification was performed

Anahtar Kelimeler

Chromophobe renal cell carcinoma, sarcomatoid renal carcinoma, calcification

The Chromophobe Renal Cell Carcinoma with Sarcomatoid Differentiaiton

Öz

52 yaşındaki bir kadında sarkomatöz komponentlere sahip kromofob renal hücreli kanserli nadir bir olgu sunmaktayız. Tümör, 70x60mm boyutunda, abdominal ultrasonla rastlantısal olarak bulundu. Abdominal bilgisayarlı tomografi sağ böbrek üst polden kaynaklanan sınırları belirgin solid bir tümör gösterdi. Histolojik olarak, tümör birbirine geçmiş iki farklı morfolojik komponentten ibaretti: kromofob renal hücreli kanser ve yüksek grade'li iğsi hücreli sarkom. Rabdoid hücrelerle karışmış oldukça atipik iğsi hücrelerden ibaret sarkomatoid bölge vardı. Bu tümörün eşsiz histolojik bulgusu kalsifikasyonun varlığı ve tümör boyunca psammoma yapı oluşumuydu. Bu olgunun kromofob renal hücreli karsinomdan sarkomatöz renal hücreli kansere bir tümör progresyon yolunun varlığını desteklediğini düşünmekteyiz. Kalsifikasyonlu sarkomatöz kromofob renal hücreli kanser üzerine literatür gözden geçirildi

Anahtar Kelimeler

Kromofob renal hücreli karsinom, sarkomatoid renal karsinom, kalsifikasyon

Kaynakça

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