Association of IL-10 and IL-6 Gene Polymorphisms with Type 2 Diabetes Mellitus among Egyptian Patients

Yıl 2013, Cilt: 10 Sayı: 3, - 2, 01.09.2013

Mohamed Helaly El-sayed Hatata Megahed Abo El-magd Afaf Alsaid İbrahim Abd El-aal Ahmad Settin

Öz

Recent findings indicate that certain cytokines are capable of interfering with insulin sensitive glucose uptake and induce insulin resistance. To test for the association of IL-10–1082 and IL-6–174 genetic polymorphisms with type 2 diabetes mellitus in Egyptian patients. Participants included 69 cases with type 2 DM (31 males and 38 females) with a median age of 57 years in addition to 98 healthy unrelated controls from the Nile Delta region, Egypt. Compared to controls, cases with type 2 diabetes mellitus showed a highly significant increase in the frequency of IL-10–1082 GG genotype (p

Anahtar Kelimeler

IL-10, IL-6, gene polymorphism, type 2 diabetes, Egypt

Association of IL-10 and IL-6 Gene Polymorphisms with Type 2 Diabetes Mellitus among Egyptian Patients

Öz

Son yıllarda bazı sitokinlerin insülin duyarlı glikoz alınımı ile ilişkiye girebilme ile birlikte insülin direnci meydana getirebilme yeteneğine sahip olduğu bildirilmiştir. Mısırlı tip 2 diabetli hastalarda L-10–1082 and IL-6–174 genetik poliformizm ilişkisini test etmek için ortalama yaşı 57 olan 69 hasta (31 E ve 38 K) ve sağlıklı 98 kişi Nil deltasından çalışmaya alındı. Kontrol grubu ile karşılaştırıldığında tip 2 diabetli hastalar yüksek oranda L-10–1082 GG genotipe (p<0.001, OR = 11.24), IL-10–1082 G allele (p<0.001, OR = 2.2) ve düşük oranda IL-10–1082 GA genotype (p<0.001, OR = 0.22) sahip olduğu gösterilmiştir. Diğer bir sonuç, IL-6–174 CC genotipi sıklıkla diabetli grupta yüksekti (p<0.001, OR = 5.41), IL-6–174 GC ise düşüktü. IL-6–174 GC genotipinde ise her grupta anlamlı farklılık göstermedi. Diğer bir sonuç ise IL-6–174 CC genotip sıklığı diabetikli hastalarda oldukça yüksekti (p<0.001, OR = 5.41), bunun aksine IL-6–174 GC genotipi anlamlı derecede düşüktü (p=0.005, OR = 0.31). G or C allelic sıklığı her iki grupta aynı idi (p>0.05). IL-10–1082 GG ve IL-6–174 CC genotipi ile ilişkili poliformizm Mısır'lı hastalarda bir risk faktörü olabilir

Anahtar Kelimeler

IL-10, IL-6, gen poliformizmi, tip 2 diabet, Mısır

Kaynakça

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