Alanine Aminotransferase Levels in Nile Delta Citizens Infected with Chronic Hepatitis C Virus

Ehab Elsayed Abdel-khalek; Ashraf El-fakhry; Mohamed Helaly; İbrahim Abdel-aal; Khaled Zalata

Alanine Aminotransferase Levels in Nile Delta Citizens Infected with Chronic Hepatitis C Virus

Yıl 2012, Cilt: 9 Sayı: 4, 247 - 252, 01.12.2012

Ehab Elsayed Abdel-khalek Ashraf El-fakhry Mohamed Helaly İbrahim Abdel-aal Khaled Zalata

Öz

Approximately 30% of patients with chronic hepatitis C have persistently normal serum alanine aminotransferase (ALT) levels. In most of the previous studies, the follow-up period of ALT levels did not exceed 12 months. Our objective was to redefine the terms persistently normal alanine aminotransferase (PNALT), persistently elevated ALT (PEALT), and fluctuating ALT (FLUXALT) and to determine the proportion of each group among Nile Delta patients. 348 patients infected with chronic hepatitis C were included, HCV infection was proved by a polymerase chain reaction. We studied an average of 19 ALT measurements for each participant between 2004 and 2007 with 2-month interval between successive measurements. We defined a patient as having PNALT, PEALT, or FLUXALT when all the 19 ALT levels were normal (40 IU/L), or did not fit either of the above two categories, respectively, during the 36-month follow-up period. 73 patients had PNALT, 157 had PEALT, and 118 had FLUXALT (P

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