BibTex RIS Kaynak Göster

Evaluating the Clinicopathologic Characteristics and Survival Outcome of Breast Cancer Patients with Isolated Brain Metastases after Adjuvant Treatment or at Initial Diagnosis

Yıl 2012, Cilt: 9 Sayı: 4, 265 - 269, 01.12.2012

Öz

CNS metastases usually appears late in the progression of metastatic breast cancer. Classical approach is evaluating and treat­ing them when symptoms become evident. We evaluated the survival and described clinicopathologic characteristics of patients in whom the brain metastases after adjuvant treatment or at initial diagnosis are the first and the only side. Authors retrospec­tively evaluated about 3600 patients with breast cancer treated in two university hospitals. In those 31 patients with first and only metastases to brain and no other metastases were evaluated. ER, PR, cerbB2 status T, N stage, grade, adjuvant taxane, trastuzumab, hormonal treatment, trastuzumab and platine use after brain metastases didn\'t effect the survival. Surgery and WBRT may be more effective in cerbB2 negative patients, WBRT in cerbB2 positive ones. (p=0.06). The survival outcome may be better in pre and perimenouposal women. The mOS of pre and perimenopausal, postmenopausal women were 17.7 months and 10.3 months respectively (p=0.06) and lapatinib may affect the mOS of patients with isolated brain metastases. Some prognostic factor may help us to foresee which group may benefit more from which treatment modality. The need for studies with larger groups of patients is obvious.

Kaynakça

  • DiStefano A, Yap HY, Hortobagyi GN, Blumenschein GR. The natural history of breast cancer patients with brain metastases. Cancer 1979;44:1913–18.
  • Engel J, EcKel R, Aydemir U, Schlesinger­Raab A, Dirschedl P, Hölzel D. Determinants and prognoses of locoregional and distant progression in breast cancer. Int J Radiat Oncol Biol Phys 2003;55:1186–95.
  • Crivellari D, Pagani O, Veronesi A, et al. High incidence of central nervous system involvement in patients with metastatic or locally advanced breast cancer treated with epirubicin and docetaxel. Ann Oncol 2001;12:353–56.
  • Dawood S, Broglio K, Esteva FJ, et al. Defining progno­ sis for women with breast cancer and CNS metastases by HER2 status. Ann Oncol 2008;19:1242­48.
  • Boogerd W, Vos VW, Hart AA, Baris G. Brain metastases in breast cancer; natural history, prognostic factors and outcome. J Neurooncol 1993;15:165–74.
  • Pestalozzi BC, Zahrieh D, Price KN, et al. Identifying breast cancer patients at risk for Central Nervous System (CNS) metastases in trials of the International Breast Cancer Study Group (IBCSG). Ann Oncol 2003;17:935–44.
  • Miller KD, Weathers T, Haney LG, et al. Occult central nervous system involvement in patients with metastatic breast cancer: prevalence, predictive factors and impact on overall survival. Ann Oncol 2003;4:1072–77.
  • Patchell RA, Tibbs PA, Walsh JW, et al. A randomized trial of surgery in the treatment of single metastases to the brain. N Engl J Med 1990;322:494–500.
  • Cetin B, Benekli M, Oksuzoglu B, et al. Lapatinib plus Capecitabine for Brain Metastases in Patients with Human Epidermal Growth Factor Receptor 2­Positive Advanced Breast Cancer: A Review of the Anatolian Society of Medical Oncology (ASMO). Experience Onkologie 2012;35:740–5.
  • Altundag K, Bondy ML, Mirza NQ, et al. Clinicopathologic Characteristics and Prognostic Factors in 420 Metastatic Breast Cancer Patients With Central Nervous System Metastasis. Cancer 2007;110:2640–7.

Evaluating the Clinicopathologic Characteristics and Survival Outcome of Breast Cancer Patients with Isolated Brain Metastases after Adjuvant Treatment or at Initial Diagnosis

Yıl 2012, Cilt: 9 Sayı: 4, 265 - 269, 01.12.2012

Öz

-

Kaynakça

  • DiStefano A, Yap HY, Hortobagyi GN, Blumenschein GR. The natural history of breast cancer patients with brain metastases. Cancer 1979;44:1913–18.
  • Engel J, EcKel R, Aydemir U, Schlesinger­Raab A, Dirschedl P, Hölzel D. Determinants and prognoses of locoregional and distant progression in breast cancer. Int J Radiat Oncol Biol Phys 2003;55:1186–95.
  • Crivellari D, Pagani O, Veronesi A, et al. High incidence of central nervous system involvement in patients with metastatic or locally advanced breast cancer treated with epirubicin and docetaxel. Ann Oncol 2001;12:353–56.
  • Dawood S, Broglio K, Esteva FJ, et al. Defining progno­ sis for women with breast cancer and CNS metastases by HER2 status. Ann Oncol 2008;19:1242­48.
  • Boogerd W, Vos VW, Hart AA, Baris G. Brain metastases in breast cancer; natural history, prognostic factors and outcome. J Neurooncol 1993;15:165–74.
  • Pestalozzi BC, Zahrieh D, Price KN, et al. Identifying breast cancer patients at risk for Central Nervous System (CNS) metastases in trials of the International Breast Cancer Study Group (IBCSG). Ann Oncol 2003;17:935–44.
  • Miller KD, Weathers T, Haney LG, et al. Occult central nervous system involvement in patients with metastatic breast cancer: prevalence, predictive factors and impact on overall survival. Ann Oncol 2003;4:1072–77.
  • Patchell RA, Tibbs PA, Walsh JW, et al. A randomized trial of surgery in the treatment of single metastases to the brain. N Engl J Med 1990;322:494–500.
  • Cetin B, Benekli M, Oksuzoglu B, et al. Lapatinib plus Capecitabine for Brain Metastases in Patients with Human Epidermal Growth Factor Receptor 2­Positive Advanced Breast Cancer: A Review of the Anatolian Society of Medical Oncology (ASMO). Experience Onkologie 2012;35:740–5.
  • Altundag K, Bondy ML, Mirza NQ, et al. Clinicopathologic Characteristics and Prognostic Factors in 420 Metastatic Breast Cancer Patients With Central Nervous System Metastasis. Cancer 2007;110:2640–7.
Toplam 10 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Makaleler
Yazarlar

Melih Cem Börüban Bu kişi benim

Hüseyin Gülyer Bu kişi benim

Kadri Altundag Bu kişi benim

Mehmet Artaç Bu kişi benim

Tunc Güler Bu kişi benim

Mustafa Cengiz Bu kişi benim

Yayımlanma Tarihi 1 Aralık 2012
Yayımlandığı Sayı Yıl 2012 Cilt: 9 Sayı: 4

Kaynak Göster

APA Börüban, M. C., Gülyer, H., Altundag, K., Artaç, M., vd. (2012). Evaluating the Clinicopathologic Characteristics and Survival Outcome of Breast Cancer Patients with Isolated Brain Metastases after Adjuvant Treatment or at Initial Diagnosis. European Journal of General Medicine, 9(4), 265-269.
AMA Börüban MC, Gülyer H, Altundag K, Artaç M, Güler T, Cengiz M. Evaluating the Clinicopathologic Characteristics and Survival Outcome of Breast Cancer Patients with Isolated Brain Metastases after Adjuvant Treatment or at Initial Diagnosis. European Journal of General Medicine. Aralık 2012;9(4):265-269.
Chicago Börüban, Melih Cem, Hüseyin Gülyer, Kadri Altundag, Mehmet Artaç, Tunc Güler, ve Mustafa Cengiz. “Evaluating the Clinicopathologic Characteristics and Survival Outcome of Breast Cancer Patients With Isolated Brain Metastases After Adjuvant Treatment or at Initial Diagnosis”. European Journal of General Medicine 9, sy. 4 (Aralık 2012): 265-69.
EndNote Börüban MC, Gülyer H, Altundag K, Artaç M, Güler T, Cengiz M (01 Aralık 2012) Evaluating the Clinicopathologic Characteristics and Survival Outcome of Breast Cancer Patients with Isolated Brain Metastases after Adjuvant Treatment or at Initial Diagnosis. European Journal of General Medicine 9 4 265–269.
IEEE M. C. Börüban, H. Gülyer, K. Altundag, M. Artaç, T. Güler, ve M. Cengiz, “Evaluating the Clinicopathologic Characteristics and Survival Outcome of Breast Cancer Patients with Isolated Brain Metastases after Adjuvant Treatment or at Initial Diagnosis”, European Journal of General Medicine, c. 9, sy. 4, ss. 265–269, 2012.
ISNAD Börüban, Melih Cem vd. “Evaluating the Clinicopathologic Characteristics and Survival Outcome of Breast Cancer Patients With Isolated Brain Metastases After Adjuvant Treatment or at Initial Diagnosis”. European Journal of General Medicine 9/4 (Aralık 2012), 265-269.
JAMA Börüban MC, Gülyer H, Altundag K, Artaç M, Güler T, Cengiz M. Evaluating the Clinicopathologic Characteristics and Survival Outcome of Breast Cancer Patients with Isolated Brain Metastases after Adjuvant Treatment or at Initial Diagnosis. European Journal of General Medicine. 2012;9:265–269.
MLA Börüban, Melih Cem vd. “Evaluating the Clinicopathologic Characteristics and Survival Outcome of Breast Cancer Patients With Isolated Brain Metastases After Adjuvant Treatment or at Initial Diagnosis”. European Journal of General Medicine, c. 9, sy. 4, 2012, ss. 265-9.
Vancouver Börüban MC, Gülyer H, Altundag K, Artaç M, Güler T, Cengiz M. Evaluating the Clinicopathologic Characteristics and Survival Outcome of Breast Cancer Patients with Isolated Brain Metastases after Adjuvant Treatment or at Initial Diagnosis. European Journal of General Medicine. 2012;9(4):265-9.