SINGLE DOSE OF TIOTROPIUM DOES NOT EFFECT HEART RATE VARIABILITY

Yıl 2006, Cilt: 3 Sayı: 3, 102 - 107, 01.09.2006

Mehmet Unlu Mehmet Melek Fatma Fidan Celal Kilit Levent Tetik Dayimi Kaya

Öz

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Anahtar Kelimeler

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SINGLE DOSE OF TIOTROPIUM DOES NOT EFFECT HEART RATE VARIABILITY

Öz

Aim: Anticholinergic drugs may alter cardiac autonomic modulation. The aim of this study was to investigate the effects of inhaled tiotropium on heart rate variability (HRV). Methods: A randomized, double-blind, crossover design study was conducted on 11 healthy volunteers. Tiotropium or placebo was administered in two different testing sessions. Time domain parameters; mean R-R interval (mean-RR), the standard deviation of R-R interval (SDNN) and the root mean square of successive R-R interval differences (RMSSD) and power spectral analysis of HRV were assessed in the supine position, during handgrip exercise and controlled breathing before and after drug administration. Results: There were no statistically significant difference in baseline HRV parameters obtained before each drug administration (p >0.05). HRV parameters obtained after each drug administration were found not to be different during supine position, controlled breathing and handgrip exercise. Conclusion: Administration of single dose tiotropium did not effect cardiac autonomic modulations in healthy volunteers. Key words: Tiotropium, heart rate variability, healthy volunteer

Anahtar Kelimeler

Tiotropium, heart rate variability, healthy volunteer

Kaynakça

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