Mechanism of Action of Jatropha Gossypifolia Stem Latex As a Haemostatic Agent

Yıl 2005, Cilt: 2 Sayı: 4, 140 - 143, 01.12.2005

Taofeeq Oduola Ganiyu Oyebola Adeosun Tesleem Aderemi Oduola Godwin Ovie

Öz

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Anahtar Kelimeler

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Mechanism of Action of Jatropha Gossypifolia Stem Latex As a Haemostatic Agent

Öz

Aim: Jatropha gossypifolia belongs to the family “Euphorbiacea”. The coagulant activity and the mechanism of action of Jatropha gossypifolia stem latex as a haemostatic agent were investigated. Methods: The mechanism of action was investigated using doubling dilution technique by mixing neat (undiluted) and serial dilutions of the latex with 30% bovine albumin. Results: The results of whole blood clotting time using Lee and White method and bleeding time using Ivy\'s method were significantly reduced (P < 0.05) when stem latex was introduced than when the tests were performed without stem latex. This means that the stem latex possesses procoagulant activity. Conclusion: The result of this test showed that precipitation of coagulant factors is the mechanism of action of its haemostatic activity. Keywords: Jatropha gossypifolia, haemostatic agent, mechanism.

Anahtar Kelimeler

Jatropha gossypifolia, haemostatic agent, mechanism