Closure of the patent ductus arteriosus with ibuprofen and other non-steroidal anti-inflammatory medications in neonates

Abstract

Abstract. Pharmacological closure of patent ductus arteriosus in pre-term infants with indomethacin has been applied since the late 1970s.  However, because of complications, a search for a safer and efficacious alternative continues.  In this review, we look at the available evidence in the literature for and against closure of the  patent ductus arteriosus with non-steroidal anti-inflammatory medications, and we present the results of our own pilot study looking at the safety and efficacy of orally administered ibuprofen on premature infants with clinically significant patent ductus arteriosus. 

Key words:  Patent ductus arteriosus, ibuprofen, premature neonates

Keywords

• Patent ductus arteriosus, ibuprofen, premature neonates

Kaynakça

1. Malviya MN, Ohlsson A, Shah SS. Surgical versus medical treatment with cyclooxygenase inhibitors for symptomatic patent ductus arteriosus in preterm infants. Cochrane Database of Systematic Reviews 2008, Issue 1. Art. No.: CD003951. DOI:10. 1002/14651858. CD003951. pub2.
2. Fuji A, Brown E, Mirochnick M, O’Brien S, Kaufman G. Neonatal necrotizing enterocolitis with intestinal perforation in extremely premature infants receiving early indomethacin treatment for patent ductus arteriosus. J Perinatol 2002; 22: 535–540.
3. Grosfeld JL, Chaet M, Molinari F, et al. Increased risk of necrotizing enterocolitis in premature infants with patent ductus arteriosus treated with indomethacin. Ann. Surg 1996; 224: 350–357.
4. Patel J, Marks KA, Roberts I, Azzopardi D, Edwards AD. Ibuprofen treatment of patent ductus arteriosus. The Lancet 1995; 346: 255.
5. Varvarigou A, Bardin CL, Beharry K, et al. Early ibuprofen administration to prevent patent ductus arteriosus in premature newborn infants. JAMA 1996; 275: 539-544.
6. Van Overmeire B, Follens I, Hartmann S, Creten WL, Van Acker KJ. Treatment of patent ductus arteriosus with ibuprofen. Archives of Disease in childhood 1997; 76: F179 – F184.
7. Van Overmeire B, Smets K, Lecoutere D, et al. A comparison of ibuprofen and indomethacin for closure of patent ductus arteriosus. N Eng J Med 2000; 343: 674–681.
8. Ohlsson A, Walia R, Shah S. Ibuprofen for the treatment of patent ductus arteriosus in preterm and/or low birthweight infants. Cochrane Database of Systematic Reviews 2008, Issue1. Art.No.: CD003481.DOI:10.1002/14651858.CD003481.pub 3.

9. Ng PC, So KW, Fok TF, et al. Comparing sulindac with indomethacin for closure of ductus arteriosus in preterm infants. J Paediatr Child Health 1997; 33: 324–332.
10. Lesko SM, Mitchell AA. Renal function after short-term ibuprofen use in infants and children. Pediatrics 1997; 100: 954–957.
11. Walson PD. Comparison of multidose ibuprofen vs. acetaminophen therapy in febrile children. Am J Dis Child 1992; 146: 626–632.
12. Aranda JV, Varvarigou A, Beharry K, et al. Pharmacokinetics and protein binding of intravenous ibuprofen in the premature newborn infant. Acta Paediatr 1997; 86: 289–293.
13. Van Overmeire B, Tuow D, Schepens PJC, Kearns GL, van den Anker JN. Ibuprofen pharmacokinetics in preterm infants with patent ductus arteriosus. Clin Pharmacol Ther 2001; 70: 336–343.
14. Sharma PK, Garg SK, Narang A. Pharmacokinetics of oral ibuprofen in premature infants. J Clin Pharmacol 2003; 43: 968–973.
15. Hirt D, Van Overmeire B, Treluyer JM, et al. An optimized ibuprofen dosing scheme for preterm neonates with patent ductus arteriosus, based on a population pharmacokinetic and pharmacodynamic study. Br J Clin Pharmacol 2008; 65: 629– 636.
16. Hariprasad P, Sundarrajan V, Srimathy G, Suthagar B, Ramadevi BS. Oral ibuprofen for closure of hemodynamically significant PDA in premature neonates. Indian Pediatrics 2002; 39: 99–100.
17. Supapannachart S, Limrungsikul A, Khowsathit P. Oral ibuprofen and indomethacin for treatment of patent ductus arteriosus in premature infants: a randomized trial at Ramathibodi Hospital. J Med Assoc Thai 2002; 85 Suppl 4: S1252 – S1258.
18. Chotigeat U, Jirapa K, Layangkool TA. Comparison of oral ibuprofen and intravenous indomethacin for closure of PDA in pre-term infants. J Med Assoc Thai 2003; 86 Suppl 3: S563–S569.
19. Heyman E, Morag I, Batash D, et al. Abstract. Closure of patent ductus arteriosus with oral ibuprofen suspension in premature newborns: A Pilot Study. Pediatrics 2003; 112: e354.
20. Cherif A, Khrouf N, Jabnoun S, et al. Randomized pilot study comparing oral ibuprofen with intravenous ibuprofen in very low birth weight infants with patent ductus arteriosus. Pediatrics 2008; 122: e1256– e1261.
21. Amoozgar H, Ghodstehrani M, Pishva N. Oral ibuprofen and ductus arteriosus closure in full- term neonates: A prospective case-control study. Pediatr Cardiol DOI 10.1007/s00246-009-9542-y (publication online 20 October 2009).