Clustering seizures associated with rotavirus gastroenteritis in a two-month-old infant

Abstract

 

Abstract. We present a case of 2-month-old infant with clustered convulsions and transient lactic acidosis associated with mild gastroenteritis caused by rotavirus. This is an unusual age for infection-related seizures. Rotavirus RNA was detected by RT-PCR in both fecal and cerebrospinal fluid (CSF) samples and were genotyped as G1 and G1(P8), respectively.  

 

Key words: rotavirus, gastroenteritis, seizures, infant.

 

 

 

Keywords

• rotavirus, gastroenteritis, seizures, infant

Kaynakça

1. Centers for Disease Control and Prevention (CDC). Rotavirus surveillance--worldwide, 2001- 2008. MMWR Morb Mortal Wkly Rep 2008; 57: 1255-1257.
2. Morooka K. Convulsions and mild diarrhea (in Japanese). Shonika (Tokyo) 1982:21: 131-137.
3. Caraballo RH, Gañez L, Santos Cde L, et al. Benign infantile seizures with mild gastroenteritis: study of 22 patients. Seizure 2009; 18: 686-689.
4. Fernández Fernández MA, Madruga Garrido M, Blanco Martínez B, Rufo Campos M. Status epilepticus associated with mild rotavirus gastroenteritis. An Pediatr (Barc) 2008; 69: 263- 266.
5. Narchi H. Benign afebrile cluster convulsion with gastroenteritis: an observacional study. BMC Pediatrics 2004; 4: 1-4.
6. Kawano G, Oshige K, Syutou S, et al. Benign infantile convulsions associated with mild gastroenteritis: a retrospective study of 39 cases including virological tests and efficacy of anticonvulsants. Brain Dev 2007; 29: 617-622.
7. Motoyama M, Ichiyama T, Matsushige T, et al. Clinical characteristics of benign convulsions with rotavirus gastroenteritis. J Child Neurol 2009; 24: 557-561.
8. Lloyd MB, Lloyd JC, Gesteland PH, Bale JF Jr. Rotavirus gastroenteritis and seizures in young children. Pediatr Neurol 2010; 42: 404-408.

9. Iturriza-Gómara M, Kang G, Gray J. Rotavirus genotyping: keeping up with an evolving population of human rotaviruses. J Clin Virol 2004; 31: 259-265.
10. Hung JJ, Wen HY, Yen MH, et al. Rotavirus gastroenteritis associated with afebrile convulsion in children: clinical analysis of 40 cases. Chang Gung Med J 2003; 26: 654-659.
11. Shiihara T, Watanabe M, Honma A, et al. Rotavirus associated acute encephalitis/encephalopathy and concurrent cerebellitis: report of two cases. Brain Dev 2007; 29: 670-673.
12. Liu B, Fujita Y, Arakawa C, et al. Detection of rotavirus RNA and antigens in serum and cerebrospinal fluid samples from diarrheic children with seizures. Jpn J Infect Dis 2009; 62: 279-283.
13. Choi J, Koh S. Role of brain inflammation in epileptogenesis. Yonsei Med J 2008; 49: 1-18.
14. Yoshida A, Kawamitu T, Tanaka R, et al. Rotavirus encephalitis: detection of the virus genomic RNA in the cerebrospinal fluid of a child. Pediatr Infect Dis J 1995; 14: 914-916.
15. Furuya Y, Katayama T, Miyahara K, Kobayashi A, Funabiki T. Detection of the rotavirus a genome from the cerebrospinal fluid of a gastroenteritis patient: a case report. Jpn J Infect Dis 2007; 60: 148-149.
16. Lynch M, Lee B, Azimi P, et al. Rotavirus and central nervous system symptoms: cause or contaminant? Case reports and review. Clin Infect Dis 2001 ;33: 932-938.
17. Lloyd MB, Lloyd JC, Gesteland PH, Bale JF Jr. Rotavirus gastroenteritis and seizures in young children. Pediatr Neurol 2010; 42: 404-408.