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Cadmium induced renal toxicity in male rats, Rattus rattus

Yıl 2010, Cilt: 15 Sayı: 3, 93 - 96, 17.01.2013

Öz

Abstract. Cadmium (Cd) is reported to cause harmful effects on organs such as kidneys, lungs, bones, liver and testes. But, the kidneys are the major target organs of Cd action. At sub-chronic exposure of CdCl2 dose (LD50 88mg kg-1), the metal accumulates in the renal cortex and results in the malfunctioning of the kidneys. we report here the effect of Cd intake in Rattus rattus of 0.6mg /kg b.wt/day of CdCl2 on rat at subchronic level. Our findings demonstrate that a regular oral intake of CdCl2 solution (in drinking water) for 30 days causes severe damage to rat kidneys. At this exposure of CdCl2, cortex region is most affected whereas glomeruli as well as proximal tubules  showed wall thickening. Cytosolic damaged bodies were also observed in the renal tubular epithelium. Since in Cd-treated rats proximal tubules in renal cortex were more heavily stained that suggesting increased protein contents in the cells. No such changes were observed in control group, which were fed with normal tap water. It is concluded that even at the high dose selected here, the extent of damage to kidneys of rat is limited.

 

Key words:  cytotoxic damage, Rattus rattus, cadmium toxicity, histopathology

Kaynakça

  • Merian E. Metals and their compounds in the environment. Occurrence, analysis and biological relevance. New York, Weinheim 1991; pp 469-479.
  • Appleton J, Lee KM, Sawicka-Kapusta K, Damek M, Cook M. The heavy metal content of the teeth of the bank vole (Clethrionomys glareolus) as an exposure marker of environmental pollution in Poland. Environ Poll 2000; 110: 441-449.
  • Domino JL. Metal-induced developmental toxicity in mammal. Toxicol Environ Health 1994; 42: 123-141.
  • Foulkes EC, Blanck S. Acute cadmium uptake by rabbit kidneys: Mechanism and effects. Toxicol Appl Pharmacol 1990; 102: 464-473.
  • Damek-Poprawa M, Sawicka-Kapusta K. Damage of the liver, kidney, and testis with reference to burden of heavy metals in yellow-necked mice from areas around steelworkers and zinc smelters in Poland. Toxicology 2003; 186: 1-10.
  • Dorian C, Gattone VH, Klaassen CD. Discrepancy between the nephrotoxic potencies of cadmium- metallothionein and cadmium chloride and the renal concentration of cadmium in the proximal convoluted tubules. Toxicol Appl Pharmacol 1995; 130: 161- 168.
  • Friberg L, Nordberg GF, Vouk VB. In: Handbook on the Toxicology of Metals. Elsevier, Amsterdam, New York, Oxford 1986; pp 521-531.
  • Ogoshi K, Yukuo N, Moriyama T. Decrease in bone strength of cadmium-treated young and old rats. Arch Toxicol 1992; 66: 315-320.
  • Kjellstrom T, Elinder CG, Friberg L. Conceptual problems in establishing the critical concentration of cadmium in human kidney cortex. Environ Res 1984; 33: 284-295.
  • Sabolic I, Herak-Kramberger CM, Blanusa M, Brown D. Loss of brush-border proteins in cadmium-induced nephrotoxicity in rat. Period Biol 2000; 102: 33-41.
  • Sabolic I, Herak-Kramberger CM, Brown D. Subchronic cadmium treatment affects the abundance and arrangement of cytoskeletal proteins in rat renal proximal tubule cells. Toxicology 2001; 165: 205- 216.
  • AFDOAQ, Association of Food and Drug Officials of the United States, Quart. Bull. 1951; 15: 122-125.
  • McManus JFA, Mowry RW. Direct examination of tissues and preparation of tissues sections and smears. Methods of general utility for the routine study of tissue. In: Staining methods, histologic and histochemical, Hoeber, New York 1960; pp 3-64.
  • Kotsonis FN, Klaassen CD. The relationship of metallothionein to the toxicity of cadmium after prolonged administration to rats. Appl Toxicol Pharmacol 1978; 46: 39.
  • Siddiqui MF, Ahmad R, Hasnain A, Ahmad W. Micronuclei induction and chromosomal aberrations in Rattus norvegicus by chloroacetic acid and chlorobenzene. Ecotox Environ Safety 2006; 65: 159- 164.
Yıl 2010, Cilt: 15 Sayı: 3, 93 - 96, 17.01.2013

Öz

Kaynakça

  • Merian E. Metals and their compounds in the environment. Occurrence, analysis and biological relevance. New York, Weinheim 1991; pp 469-479.
  • Appleton J, Lee KM, Sawicka-Kapusta K, Damek M, Cook M. The heavy metal content of the teeth of the bank vole (Clethrionomys glareolus) as an exposure marker of environmental pollution in Poland. Environ Poll 2000; 110: 441-449.
  • Domino JL. Metal-induced developmental toxicity in mammal. Toxicol Environ Health 1994; 42: 123-141.
  • Foulkes EC, Blanck S. Acute cadmium uptake by rabbit kidneys: Mechanism and effects. Toxicol Appl Pharmacol 1990; 102: 464-473.
  • Damek-Poprawa M, Sawicka-Kapusta K. Damage of the liver, kidney, and testis with reference to burden of heavy metals in yellow-necked mice from areas around steelworkers and zinc smelters in Poland. Toxicology 2003; 186: 1-10.
  • Dorian C, Gattone VH, Klaassen CD. Discrepancy between the nephrotoxic potencies of cadmium- metallothionein and cadmium chloride and the renal concentration of cadmium in the proximal convoluted tubules. Toxicol Appl Pharmacol 1995; 130: 161- 168.
  • Friberg L, Nordberg GF, Vouk VB. In: Handbook on the Toxicology of Metals. Elsevier, Amsterdam, New York, Oxford 1986; pp 521-531.
  • Ogoshi K, Yukuo N, Moriyama T. Decrease in bone strength of cadmium-treated young and old rats. Arch Toxicol 1992; 66: 315-320.
  • Kjellstrom T, Elinder CG, Friberg L. Conceptual problems in establishing the critical concentration of cadmium in human kidney cortex. Environ Res 1984; 33: 284-295.
  • Sabolic I, Herak-Kramberger CM, Blanusa M, Brown D. Loss of brush-border proteins in cadmium-induced nephrotoxicity in rat. Period Biol 2000; 102: 33-41.
  • Sabolic I, Herak-Kramberger CM, Brown D. Subchronic cadmium treatment affects the abundance and arrangement of cytoskeletal proteins in rat renal proximal tubule cells. Toxicology 2001; 165: 205- 216.
  • AFDOAQ, Association of Food and Drug Officials of the United States, Quart. Bull. 1951; 15: 122-125.
  • McManus JFA, Mowry RW. Direct examination of tissues and preparation of tissues sections and smears. Methods of general utility for the routine study of tissue. In: Staining methods, histologic and histochemical, Hoeber, New York 1960; pp 3-64.
  • Kotsonis FN, Klaassen CD. The relationship of metallothionein to the toxicity of cadmium after prolonged administration to rats. Appl Toxicol Pharmacol 1978; 46: 39.
  • Siddiqui MF, Ahmad R, Hasnain A, Ahmad W. Micronuclei induction and chromosomal aberrations in Rattus norvegicus by chloroacetic acid and chlorobenzene. Ecotox Environ Safety 2006; 65: 159- 164.
Toplam 15 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Articles
Yazarlar

Mohammad Faisal Siddiqui Bu kişi benim

Yayımlanma Tarihi 17 Ocak 2013
Yayımlandığı Sayı Yıl 2010 Cilt: 15 Sayı: 3

Kaynak Göster

APA Siddiqui, M. F. (2013). Cadmium induced renal toxicity in male rats, Rattus rattus. EASTERN JOURNAL OF MEDICINE, 15(3), 93-96.
AMA Siddiqui MF. Cadmium induced renal toxicity in male rats, Rattus rattus. EASTERN JOURNAL OF MEDICINE. Mart 2013;15(3):93-96.
Chicago Siddiqui, Mohammad Faisal. “Cadmium Induced Renal Toxicity in Male Rats, Rattus Rattus”. EASTERN JOURNAL OF MEDICINE 15, sy. 3 (Mart 2013): 93-96.
EndNote Siddiqui MF (01 Mart 2013) Cadmium induced renal toxicity in male rats, Rattus rattus. EASTERN JOURNAL OF MEDICINE 15 3 93–96.
IEEE M. F. Siddiqui, “Cadmium induced renal toxicity in male rats, Rattus rattus”, EASTERN JOURNAL OF MEDICINE, c. 15, sy. 3, ss. 93–96, 2013.
ISNAD Siddiqui, Mohammad Faisal. “Cadmium Induced Renal Toxicity in Male Rats, Rattus Rattus”. EASTERN JOURNAL OF MEDICINE 15/3 (Mart 2013), 93-96.
JAMA Siddiqui MF. Cadmium induced renal toxicity in male rats, Rattus rattus. EASTERN JOURNAL OF MEDICINE. 2013;15:93–96.
MLA Siddiqui, Mohammad Faisal. “Cadmium Induced Renal Toxicity in Male Rats, Rattus Rattus”. EASTERN JOURNAL OF MEDICINE, c. 15, sy. 3, 2013, ss. 93-96.
Vancouver Siddiqui MF. Cadmium induced renal toxicity in male rats, Rattus rattus. EASTERN JOURNAL OF MEDICINE. 2013;15(3):93-6.