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Impact of occupational lead exposure on industrial workers health condition in Tehran-Iran

Yıl 2005, Cilt: 10 Sayı: 1-2, 20 - 23, 20.03.2013

Öz

Abstract. The continual occurrence of occupational lead exposure remains a serious  problem worldwide despite awareness of its adverse health effect. Blood lead Level (BLL) in a group of 31  male non smoking  industrial  workers  was determined. Then possible relationships between  BLL and health condition of workers , employment years,   and   fatigue and chronic bone pain symptom  were investigated. Workers  Blood lead level (BLL) were determined  by  GTA_AA-220  and hematology parameters were determined by Sysmex-K1000. The  workers  age mean  and employment years mean were  38± 8 years and 12±7.0 years respectively and BLL ranged from 15.50 µg/dL to 59.99 ug/dL with mean=34.80±12.90 µg/dL.  The pearson product moment test  indicated no correlations between BLL and Hgb (r =-0.09 & p=0.62  )  and BLL & Hct  ( r = -0.14 & p=0.46  ). However, BLL & employment years correlated (r = 0.37 & p= 0.04).  To investigate the effect of BLL on fatigue and  bone pain,  we used independent t-sample test and  results  indicated 23/31 workers with fatigue and bone pain had  higher BLL than those (8/31) without the symptoms ( mean= 38.41µg/dL vs mean= 20.44µg/dL, t= 6.06,p=0.00). Furthermore, they had many years of employment  (mean=13.4 years vs mean=8.8 years , t= 2.07, p=0.04 ).   In our study 74% of the exposed workers  complained of fatigue and  chronic bone pain with  BLL ( mean=38.41 µg/dL) and   employment ( mean=13.4 years). We conclude that  occurrence of    fatigue and chronic  bone pain symptom   may  associate with high blood lead level and   thus complementary to routine  BLL measurement and screening, bone lead   measurement  can be   an  important tool  in the study of chronic lead exposure among non-smoker and industrially  lead  exposed workers as well .

Keywords: Electrothermal atomic absorption spectroscopy, occupational lead exposure.

Kaynakça

  • 1. Rabinowitz MB. Wetherill GW.Kopple JD. Kinetic analysis of lead metabolism in healthy humans. J Clin Invest 1976;58:260-270.
  • 2. Pounds JG. Long GJ. Rosen JF. Cellular and molecular toxicity of lead in bone. Envir Helth Persp 1991;91:17-32.
  • 3. U.S.CDC. Preventing lead poisoning in young children. Atlanta, GA: Center for disease control and prevention,1991.
  • 4. Jakubowski M, Tizcinka-Ochocka M, Razniewska G, Frydrych J. Blood lead levels in industrial workers in Poland. Int J Occup Med Environ Health 1998; 11(1): 59-67.
  • 5. Case studies: lead poisoning. Br J Clin Pharmacol; 2002; 53(5): 451-458.
  • 6. Moreira FR. Moreira JC. Effects of lead exposure on the human body and health implications. Rev Panam Salud Publica 2004; 15(2):119-29.
  • 7. The Washington Industrial Safety and Health Act’s (WISHA), Standard for inorganic Lead in the Construction Industry, WAC 296-155- 17650(2)(b)(i) and (ii)1993.
  • 8. Parsons PJ. Slavin W. A rapid Zeeman graphite furnace atomic absorption spectrometric method for the determination of lead in blood. Spectrochim Acta, Part B 1993; 48:925-939.
  • 9. Flajnik, C. Shrader, D. Determination of Lead in Blood by GFAAS- Deuterium and Zeeman Background Correction. Varian Australia; Technical Note; A-110. 1993.
  • 10. Hu H. .Bone lead as a new biological marker of lead dose: recent findings and implications for public health. Environ Health Perspect; 1998;106: Suppl4:961-7.
  • 11. Coyle P, Kosnett MJ. Hipkins K. Severe lead poisoning in the plastics industry: a report of three cases. Am J Ind Med 2005; 47(2):172-5.
  • 12. Suplido ML, Ong CN. Lead exposure among small scale battery recyclers, automobile radiator mechanics, and their children in Manil the Philippines. Environ Res 2000; 82: 231-238.
  • 13. Bashir R, Khan DA, Saleem M, Zaman KU, Malik IA. Blood lead levels and anemia in lead exposed workers. J Pak Med Assoc 1995; 45: 64-66.
  • 14. Aliasgharpour Mehri, Abbassi Mohammad . The absence of hematological outcome in workers occupationally exposed to lead in Tehran-Iran. Haema 2006; 9(3):398-400.
  • 15. Klein RF. Wiren KM . Regulation of osteoblastic gene expression by lead. Endocrinology 1993 ;132 (6):2531-7.
  • 16. Goldstein GW. Development neurobiology of lead toxicity. In: Needleman HL. Ed. Human lead exposure. Boca raton, FL: CRC Press 1991:125- 136.
  • 17. Silbergeld EK. Sauk J, Somerman.M. Todd A.McNeill F. Fowler B. Fontaine A. van Buren J. Lead in bone: storage site, exposure source , and target organ. Neurotoxicology; 1993; 14(2-3):225- 36.
  • 18. Aguilar–Madrid G. Piacitelli GM. Juarez-Perez CA. Vazquez-Grameix JH. Hu H. Hernandez-Avila M. Occupational exposure to inorganic lead in a printing plant in Mexico City. Salud Publica Mex 1999;41(1): 42-54.
Yıl 2005, Cilt: 10 Sayı: 1-2, 20 - 23, 20.03.2013

Öz

Kaynakça

  • 1. Rabinowitz MB. Wetherill GW.Kopple JD. Kinetic analysis of lead metabolism in healthy humans. J Clin Invest 1976;58:260-270.
  • 2. Pounds JG. Long GJ. Rosen JF. Cellular and molecular toxicity of lead in bone. Envir Helth Persp 1991;91:17-32.
  • 3. U.S.CDC. Preventing lead poisoning in young children. Atlanta, GA: Center for disease control and prevention,1991.
  • 4. Jakubowski M, Tizcinka-Ochocka M, Razniewska G, Frydrych J. Blood lead levels in industrial workers in Poland. Int J Occup Med Environ Health 1998; 11(1): 59-67.
  • 5. Case studies: lead poisoning. Br J Clin Pharmacol; 2002; 53(5): 451-458.
  • 6. Moreira FR. Moreira JC. Effects of lead exposure on the human body and health implications. Rev Panam Salud Publica 2004; 15(2):119-29.
  • 7. The Washington Industrial Safety and Health Act’s (WISHA), Standard for inorganic Lead in the Construction Industry, WAC 296-155- 17650(2)(b)(i) and (ii)1993.
  • 8. Parsons PJ. Slavin W. A rapid Zeeman graphite furnace atomic absorption spectrometric method for the determination of lead in blood. Spectrochim Acta, Part B 1993; 48:925-939.
  • 9. Flajnik, C. Shrader, D. Determination of Lead in Blood by GFAAS- Deuterium and Zeeman Background Correction. Varian Australia; Technical Note; A-110. 1993.
  • 10. Hu H. .Bone lead as a new biological marker of lead dose: recent findings and implications for public health. Environ Health Perspect; 1998;106: Suppl4:961-7.
  • 11. Coyle P, Kosnett MJ. Hipkins K. Severe lead poisoning in the plastics industry: a report of three cases. Am J Ind Med 2005; 47(2):172-5.
  • 12. Suplido ML, Ong CN. Lead exposure among small scale battery recyclers, automobile radiator mechanics, and their children in Manil the Philippines. Environ Res 2000; 82: 231-238.
  • 13. Bashir R, Khan DA, Saleem M, Zaman KU, Malik IA. Blood lead levels and anemia in lead exposed workers. J Pak Med Assoc 1995; 45: 64-66.
  • 14. Aliasgharpour Mehri, Abbassi Mohammad . The absence of hematological outcome in workers occupationally exposed to lead in Tehran-Iran. Haema 2006; 9(3):398-400.
  • 15. Klein RF. Wiren KM . Regulation of osteoblastic gene expression by lead. Endocrinology 1993 ;132 (6):2531-7.
  • 16. Goldstein GW. Development neurobiology of lead toxicity. In: Needleman HL. Ed. Human lead exposure. Boca raton, FL: CRC Press 1991:125- 136.
  • 17. Silbergeld EK. Sauk J, Somerman.M. Todd A.McNeill F. Fowler B. Fontaine A. van Buren J. Lead in bone: storage site, exposure source , and target organ. Neurotoxicology; 1993; 14(2-3):225- 36.
  • 18. Aguilar–Madrid G. Piacitelli GM. Juarez-Perez CA. Vazquez-Grameix JH. Hu H. Hernandez-Avila M. Occupational exposure to inorganic lead in a printing plant in Mexico City. Salud Publica Mex 1999;41(1): 42-54.
Toplam 18 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Articles
Yazarlar

Mehri Aliasgharpour Bu kişi benim

Hamid Hagani Bu kişi benim

Yayımlanma Tarihi 20 Mart 2013
Yayımlandığı Sayı Yıl 2005 Cilt: 10 Sayı: 1-2

Kaynak Göster

APA Aliasgharpour, M., & Hagani, H. (2013). Impact of occupational lead exposure on industrial workers health condition in Tehran-Iran. EASTERN JOURNAL OF MEDICINE, 10(1-2), 20-23.
AMA Aliasgharpour M, Hagani H. Impact of occupational lead exposure on industrial workers health condition in Tehran-Iran. EASTERN JOURNAL OF MEDICINE. Mart 2013;10(1-2):20-23.
Chicago Aliasgharpour, Mehri, ve Hamid Hagani. “Impact of Occupational Lead Exposure on Industrial Workers Health Condition in Tehran-Iran”. EASTERN JOURNAL OF MEDICINE 10, sy. 1-2 (Mart 2013): 20-23.
EndNote Aliasgharpour M, Hagani H (01 Mart 2013) Impact of occupational lead exposure on industrial workers health condition in Tehran-Iran. EASTERN JOURNAL OF MEDICINE 10 1-2 20–23.
IEEE M. Aliasgharpour ve H. Hagani, “Impact of occupational lead exposure on industrial workers health condition in Tehran-Iran”, EASTERN JOURNAL OF MEDICINE, c. 10, sy. 1-2, ss. 20–23, 2013.
ISNAD Aliasgharpour, Mehri - Hagani, Hamid. “Impact of Occupational Lead Exposure on Industrial Workers Health Condition in Tehran-Iran”. EASTERN JOURNAL OF MEDICINE 10/1-2 (Mart 2013), 20-23.
JAMA Aliasgharpour M, Hagani H. Impact of occupational lead exposure on industrial workers health condition in Tehran-Iran. EASTERN JOURNAL OF MEDICINE. 2013;10:20–23.
MLA Aliasgharpour, Mehri ve Hamid Hagani. “Impact of Occupational Lead Exposure on Industrial Workers Health Condition in Tehran-Iran”. EASTERN JOURNAL OF MEDICINE, c. 10, sy. 1-2, 2013, ss. 20-23.
Vancouver Aliasgharpour M, Hagani H. Impact of occupational lead exposure on industrial workers health condition in Tehran-Iran. EASTERN JOURNAL OF MEDICINE. 2013;10(1-2):20-3.