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Effects of garlic on haemostatic parameters and

Yıl 2006, Cilt: 11 Sayı: 1-2, 13 - 18, 20.03.2013

Öz

Abstract. The effects of garlic on haemostatic parameters and lipid profile in hyperlipidemic rats were studied.

Thirty rats were allocated randomly into 3 groups, each of 10 rats. One group was put on normal chow diet and acted as normal control group. The other 2 groups were given high cholesterol diet for 8 weeks.

Both groups became hyperlipidemic after 8 weeks. One group received distilled water and acted as hyperlipidemic control while the other group received garlic (200mg/kg) for 4 weeks. Coagulation parameters and lipid profile were measured after 4 weeks of treatment with garlic. Blood samples were collected from all rats before and after commencement of the treatment to measure coagulation parameters, namely fibrinogen, activated partial thromboplastin time (APTT), prothrombin time (PT) and platelet count as well as serum lipid profile, namely total serum cholesterol (S.TC), serum triglyceride (S.TG), high density lipoprotein (HDL), and low density lipoprotein (LDL). These parameters were also measured after high cholesterol diet feeding. The results indicated that a significant reduction in fibrinogen, S.TC, S.TG, LDL (p<0.01); an increase in HDL (p<0.01); a prolongation in PT and APTT (p<0.01) and a significant decrease in platelet count (p<0.01) in hyperlipidemic rats after 4 weeks of treatment with garlic.Garlic may be recommended as an antiatherogenic and antithrombotic agent and is suggested to be used with food in patients with hyperlipidemia.

Key words: Garlic, hyperlipidemic, haemostatic parameters, antiatherogenic, antithrombotic

Kaynakça

  • Warshafsky S, Kamer RS, Sivak SL: Effect of garlic on total cholesterol. A meta analysis. Ann Intern Med 1993;119: 599- 605.
  • Silagy CA, McNeilji L, Donnan A: A metabolic analysis of the effect of garlic on blood pressure. J Hypertens 1994;12: 463- 468.
  • Gebhardt R, Beck H: Differential inhibitory effect of garlic derived organosulfar compounds on cholesterol biosynthesis in primary rat hepatocyte culture. Lipids 1996;31: 1269-1276.
  • Yu Yan Yeh L, Liu L: Cholesterol lowering effect of garlic extract and organosulfur compounds: Human and animal studies. J Nutr 2001;131: 9895- 9935.
  • Garcin Gomez LJ, Sanchez Muniz, FJ: Review: Cardiovascular effect of garlic “Allium stavium”. Arch Latinoam Nutr 2000;50: 219-229.
  • Rahman K: Historical perspective on garlic and cardiovascular disease. J Nutr 2001;131: 9775- 9795.
  • Sendle A, Elbl G, Steinke B: Comparative pharmacological investigations of allium urisnum and allium sativum. Planta Medica 1992;58: 1-7.
  • Fallon MB, Abrams GA, Abdel-Razek TT: Garlic prevents hypoxic pulmonary hypertension in rats. Am J Physiol 1998;272: L283-L287.
  • Kim-Park S, Ku DD: Garlic elicit, a nitric oxide- dependent relaxation and inhibits hypoxic pulmonary vasoconstriction in rats. Clin Exp Pharmacol Physiol 2000;27: 780-787.
  • Popov I, Btumstein A, Lewin G: Antioxidant effect of aqueous garlic extract. 1st. communication. Direct detection using photochemiluninescence.Arzenimittelforschung 1994;44: 602- 604.
  • Wu CC, Sheen LY, Chen HW: Effect of organosulfur compounds from garlic oil on the antioxidation system in rats liver and RBC. Food. Chem. Toxicol 2001;39: 563-569.
  • Borek C: Antioxidant health effect of aged garlic extract. J Nutr 2001;131: 1010S 1015S,.
  • Tasao S, Yin M: In vitro activity of garlic oil and diallyl sulphides against antibiotic-resistant Pseudomonas aeruginosa and Klebsiella pneumoniae. Nutr J 1994;23: 220- 223.
  • Angusti KT, Sheela CG: Antiperoxide effect of S- allyl-cystein sulfoxide, an insulin secretagogue in diabetic rats. Experientia 1996;52: 115-120.
  • Dacie JV, Lewis SM: Practical Haematology. 9th. Edition, Churchill Livingstone, London 2001;353- 357.
  • Friedwald WT, Levy RI, Fredrickson DS: Estimation of the concentration of LDL- cholesterol in plasma without use the preparative ultracentrifuge. Clin Chem 1972;18: 499-502.
  • Assmann G: Current diagnostic of hyperlipidemias. Internist 1979;20: 559-564.
  • Tietz NW: Clinical Guide to Laboratory Tests, 3rd. Edition. W.B. Saunders Co.Pheladelphia, PA.1995.
  • Legnani C, Frascaro M, Guazzaloca G: Effect of a dried garlic preparation on ibrinolysis and platelet aggregation in healthy subjects. Arzenimittelforschung 1993;43: 119-122.
  • Turner M: Garlic and circulatory disease. J R Soc Health 1990;110(3): 90-93.
  • Aro A: Garlic a spice or medicine? Douodecim. 1992;110: 90- 93.
  • Apitz Castro R, Ledezma E: The molecular basis of the antiplatelet action of ajoene : Direct interaction with the fibrinogen receptor. Biochem Biophys Res Commun 1986;141: 145-150.
  • Jamaluddin MP, Krishnan LK, Thomas A: Ajoene inhibition of platelet aggregation: Possible mediation by a haemoprotein. Biochem Biophys Res Commun 1988;153: 474 –486.
  • Srivsatava KC: Evidence of the mechanism by which garlic inhibit platelet aggregation. Prostaglandin Leukot Med 1986;22: 313-321.
  • Gupta N, Porter TD: Garlic and garlic derived compounds inhibit human squalene monooxygenase. J Nutr 2001;131: 1662- 1667.
  • Chi MS, Koh ET, Stewart TJ: Effects of garlic on lipid metabolism in rats fed cholesterol or lard. J Nutr 1982;112: 241- 248.
  • Lau Benjamin HS: Suppression of LDL oxidation by garlic. J Nutr 2001;131: 9555-9585.
  • Mc Crindle BW, Helden E, Conner WT: Garlic extract therapy in children with hypercholesterolemia. Arch-pediatr-Adolesc- Med 1998;152: 1089-1094.
Yıl 2006, Cilt: 11 Sayı: 1-2, 13 - 18, 20.03.2013

Öz

Kaynakça

  • Warshafsky S, Kamer RS, Sivak SL: Effect of garlic on total cholesterol. A meta analysis. Ann Intern Med 1993;119: 599- 605.
  • Silagy CA, McNeilji L, Donnan A: A metabolic analysis of the effect of garlic on blood pressure. J Hypertens 1994;12: 463- 468.
  • Gebhardt R, Beck H: Differential inhibitory effect of garlic derived organosulfar compounds on cholesterol biosynthesis in primary rat hepatocyte culture. Lipids 1996;31: 1269-1276.
  • Yu Yan Yeh L, Liu L: Cholesterol lowering effect of garlic extract and organosulfur compounds: Human and animal studies. J Nutr 2001;131: 9895- 9935.
  • Garcin Gomez LJ, Sanchez Muniz, FJ: Review: Cardiovascular effect of garlic “Allium stavium”. Arch Latinoam Nutr 2000;50: 219-229.
  • Rahman K: Historical perspective on garlic and cardiovascular disease. J Nutr 2001;131: 9775- 9795.
  • Sendle A, Elbl G, Steinke B: Comparative pharmacological investigations of allium urisnum and allium sativum. Planta Medica 1992;58: 1-7.
  • Fallon MB, Abrams GA, Abdel-Razek TT: Garlic prevents hypoxic pulmonary hypertension in rats. Am J Physiol 1998;272: L283-L287.
  • Kim-Park S, Ku DD: Garlic elicit, a nitric oxide- dependent relaxation and inhibits hypoxic pulmonary vasoconstriction in rats. Clin Exp Pharmacol Physiol 2000;27: 780-787.
  • Popov I, Btumstein A, Lewin G: Antioxidant effect of aqueous garlic extract. 1st. communication. Direct detection using photochemiluninescence.Arzenimittelforschung 1994;44: 602- 604.
  • Wu CC, Sheen LY, Chen HW: Effect of organosulfur compounds from garlic oil on the antioxidation system in rats liver and RBC. Food. Chem. Toxicol 2001;39: 563-569.
  • Borek C: Antioxidant health effect of aged garlic extract. J Nutr 2001;131: 1010S 1015S,.
  • Tasao S, Yin M: In vitro activity of garlic oil and diallyl sulphides against antibiotic-resistant Pseudomonas aeruginosa and Klebsiella pneumoniae. Nutr J 1994;23: 220- 223.
  • Angusti KT, Sheela CG: Antiperoxide effect of S- allyl-cystein sulfoxide, an insulin secretagogue in diabetic rats. Experientia 1996;52: 115-120.
  • Dacie JV, Lewis SM: Practical Haematology. 9th. Edition, Churchill Livingstone, London 2001;353- 357.
  • Friedwald WT, Levy RI, Fredrickson DS: Estimation of the concentration of LDL- cholesterol in plasma without use the preparative ultracentrifuge. Clin Chem 1972;18: 499-502.
  • Assmann G: Current diagnostic of hyperlipidemias. Internist 1979;20: 559-564.
  • Tietz NW: Clinical Guide to Laboratory Tests, 3rd. Edition. W.B. Saunders Co.Pheladelphia, PA.1995.
  • Legnani C, Frascaro M, Guazzaloca G: Effect of a dried garlic preparation on ibrinolysis and platelet aggregation in healthy subjects. Arzenimittelforschung 1993;43: 119-122.
  • Turner M: Garlic and circulatory disease. J R Soc Health 1990;110(3): 90-93.
  • Aro A: Garlic a spice or medicine? Douodecim. 1992;110: 90- 93.
  • Apitz Castro R, Ledezma E: The molecular basis of the antiplatelet action of ajoene : Direct interaction with the fibrinogen receptor. Biochem Biophys Res Commun 1986;141: 145-150.
  • Jamaluddin MP, Krishnan LK, Thomas A: Ajoene inhibition of platelet aggregation: Possible mediation by a haemoprotein. Biochem Biophys Res Commun 1988;153: 474 –486.
  • Srivsatava KC: Evidence of the mechanism by which garlic inhibit platelet aggregation. Prostaglandin Leukot Med 1986;22: 313-321.
  • Gupta N, Porter TD: Garlic and garlic derived compounds inhibit human squalene monooxygenase. J Nutr 2001;131: 1662- 1667.
  • Chi MS, Koh ET, Stewart TJ: Effects of garlic on lipid metabolism in rats fed cholesterol or lard. J Nutr 1982;112: 241- 248.
  • Lau Benjamin HS: Suppression of LDL oxidation by garlic. J Nutr 2001;131: 9555-9585.
  • Mc Crindle BW, Helden E, Conner WT: Garlic extract therapy in children with hypercholesterolemia. Arch-pediatr-Adolesc- Med 1998;152: 1089-1094.
Toplam 28 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Articles
Yazarlar

Omran M.o. Alhamami Bu kişi benim

Jabbar Y. Al-mayah Bu kişi benim

Najah R. Al-mousawi Bu kişi benim

Alaa G.h. Al-aoboodi Bu kişi benim

Yayımlanma Tarihi 20 Mart 2013
Yayımlandığı Sayı Yıl 2006 Cilt: 11 Sayı: 1-2

Kaynak Göster

APA Alhamami, O. M., Al-mayah, J. Y., Al-mousawi, N. R., Al-aoboodi, A. G. (2013). Effects of garlic on haemostatic parameters and. EASTERN JOURNAL OF MEDICINE, 11(1-2), 13-18.
AMA Alhamami OM, Al-mayah JY, Al-mousawi NR, Al-aoboodi AG. Effects of garlic on haemostatic parameters and. EASTERN JOURNAL OF MEDICINE. Mart 2013;11(1-2):13-18.
Chicago Alhamami, Omran M.o., Jabbar Y. Al-mayah, Najah R. Al-mousawi, ve Alaa G.h. Al-aoboodi. “Effects of Garlic on Haemostatic Parameters and”. EASTERN JOURNAL OF MEDICINE 11, sy. 1-2 (Mart 2013): 13-18.
EndNote Alhamami OM, Al-mayah JY, Al-mousawi NR, Al-aoboodi AG (01 Mart 2013) Effects of garlic on haemostatic parameters and. EASTERN JOURNAL OF MEDICINE 11 1-2 13–18.
IEEE O. M. Alhamami, J. Y. Al-mayah, N. R. Al-mousawi, ve A. G. Al-aoboodi, “Effects of garlic on haemostatic parameters and”, EASTERN JOURNAL OF MEDICINE, c. 11, sy. 1-2, ss. 13–18, 2013.
ISNAD Alhamami, Omran M.o. vd. “Effects of Garlic on Haemostatic Parameters and”. EASTERN JOURNAL OF MEDICINE 11/1-2 (Mart 2013), 13-18.
JAMA Alhamami OM, Al-mayah JY, Al-mousawi NR, Al-aoboodi AG. Effects of garlic on haemostatic parameters and. EASTERN JOURNAL OF MEDICINE. 2013;11:13–18.
MLA Alhamami, Omran M.o. vd. “Effects of Garlic on Haemostatic Parameters and”. EASTERN JOURNAL OF MEDICINE, c. 11, sy. 1-2, 2013, ss. 13-18.
Vancouver Alhamami OM, Al-mayah JY, Al-mousawi NR, Al-aoboodi AG. Effects of garlic on haemostatic parameters and. EASTERN JOURNAL OF MEDICINE. 2013;11(1-2):13-8.